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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 3 | Aspects of modeling of high voltage ferroelectric nonlinear ceramic capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1992 | IEEE Trans Compon Hydirds Manuf Technol1992，15，2： | 2 |
| 4 | Relaxation effects in high-voltage barium titanate non-linear ceramic disk capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1993 | IEEE Trans Compon Hydirds Manuf Technol1993，16，4： | 2 |
| 5 | The evolution of epidemic influenza 显示文摘 | Nelson M I Holmes E C | 2007 | Nat Rev Genet2007，8，3： | 1 |
| 6 | A review of recent progress towards development of a formulated microbound diet for mud crab, Scylla serrata, larvae and their nutritional requirements显示文摘 | HOLME M H ZENG C S SOUTHGATE P C | 2009 | Aquaculture2009，286，： | 1 |
| 7 | Estrogen-like properties of brominated analogs of bisphenol A in the MCF-7 human breast cancer cell line显示文摘 | Samuelsen M Olsen C Holme JA | 2004 | Cell Biology and Toxicology2004，17，： | 1 |
| 8 | Self- complementary oligopeptide matrices support mammalian cell attachment显示文摘 | Zhang S Holmes T C Dipersio C M | 1995 | Biomaterials1995，16，： | 1 |
| 9 | Genome edi- ting with engineered Zinc finger nucleases 显示文摘 | Urnov F D Rebar E J Holmes M C | 2010 | Nature Reviews Genetics2010，11，9： | 1 |
| 10 | Evolutionary aspects of recombination in RNA viruses显示文摘 | Worobey M Holmes E C | 1999 | J Gen Virol1999，80，10： | 1 |
| 11 | Effect of crystalloid resuscitation and inhalation injury on extravascular lung water: clinical implications 显示文摘 | Holm C Tegeler J Mayr M | 2002 | Chest2002，121，6： | 1 |
| 12 | Diagnostic accu- racy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting 显示文摘 | Shah M Variava E Holmes C B | 2009 | J Acquir Immune Defic Syndr2009，52，2： | 1 |
| 13 | Is Adherence to weight monitoring or weight-based diuretic self-adjustment associated with fewer heart failure-related emergency department visits or hospitalizations 显示文摘 | Jones C D Holmes G M | 2012 | J Card Fail2012，18，7： | 1 |
| 14 | Recombi- nation is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratorysyn- drome viruses in China显示文摘 | Shi M Holmes E C Brar M S Leung F C | 2013 | J Virol2013，87，10： | 1 |
| 15 | Alterations in digestive enzyme activities during the development of diet-induced enteritis in Atlantic salmon,Salmo salar L显示文摘 | Chikwati E M Sahlmanni C Holm H | 2013 | Aquaculture2013，，2013： | 1 |
| 16 | Field measurements of pressures on the Texas Tech building 显示文摘 | LEVITAN M L MEHTA K C VANN W P HOLMES J D | 1991 | Journal of Wind Engineering and Industrial Aerodynamics1991，38，23： | 1 |
| 17 | Gas-particle partitioning of atmospheric Hg (11) and its effect on global mercury deposition显示文摘 | Amos H M Jacob D J Holmes C D | 2012 | Atmospheric Chemistry and Physics2012，12，1： | 1 |
| 18 | Expression of CDK1 Tyr15, pCDK1 Thr161, Cyclin B1 (total) and pCyclin B1 Ser126 in vulvar squamous cell carcinoma and their relations with clinicopatological features and prognosis显示文摘 | Wang Z Slipicevic A Frsund M Trope C G Nesland J M Holm R | 2015 | PLoS One2015，10，01： | 1 |
| 19 | The application of operation and technology roadmap to aid Singaporean SMES identify and select emerging technologies 显示文摘 | HOLMES C FERRILL M | 2005 | Technology Forecasting and Social Change2005，72，3： | 1 |
| 20 | Molecular Evolution: A Phylogenetic Approach显示文摘 | Page R D M Holmes E C | 1998 | Blackwell Science Malden MA1998，1998，： | 1 |
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