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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 3 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 4 | Lipids, Apolipoproteins, and Their Ratios in Relation to Cardiovascular Events With Statin Treatment显示文摘 | John J.P. Kastelein Wim A. van der Steeg Ingar Holme Michael Gaffney Nilo B. Cater Philip Barter Prakash Deedwania Anders G. Olsson S Matthijs Boekholdt David A. Demicco Michael Szarek John C. LaRosa Terje R. Pedersen Scott M. Grundy | 2008 | Circulation2008，，23： | 3 |
| 5 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 6 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 7 | 苏鲁造山带中部晚中生代裂谷作用与深部动力机制——来自灵山岛的记录显示文摘灵山岛科学钻探井的最新成果表明,晚中生代苏鲁造山带内部发育莱阳、青山两期裂谷作用.通过野外踏勘、科学钻探、岩芯描述、锆石年代学与全岩地球化学的研究,探明了裂谷发育时代,揭露了裂谷充填序列,并探讨了其演化动力学机制.灵山岛地区莱阳-青山群地层序列呈现两期不同性质的裂谷充填序列:莱阳群(147~125Ma),主要由深水重力流沉积与少部分火成岩夹层组成;青山群下部(125~119Ma),不整合覆盖于下伏地层之上,主要由陆上火山岩与浅水陆相沉积地层组成.两期裂谷演化过程中构造环境发生了重要转变:裂谷莱阳期处于NNW-SSE向伸展拉张的构造环境,呈现出“先伸展开裂,后岩浆作用”的被动裂谷特征,在125Ma左右经历了一个短暂的NWW-SEE向挤压,结束了被动裂谷阶段,之后转变为NW-SE向强烈伸展环境,演化为青山期火山弧盆.裂谷火成岩多为钾玄岩至高钾钙碱性系列的粗面安山质与粗面质/粗面英安质熔岩或火山碎屑岩,伴有数套煌斑岩夹层与一套流纹岩.火成岩地球化学特征指示其应为地幔来源的派生熔体,且其地幔源区受到交代作用或岩浆形成过程受到了地壳混染,裂谷发育演化过程中伴随着巨量的岩石圈减薄.古太平洋板块侏罗纪低角度俯冲弱化了苏鲁造山带加厚岩石圈地幔,晚侏罗至早白垩世发生回卷,岩石圈地幔发生了重力垮塌被拆沉,导致莱阳期被动裂谷的发育.之后古太平洋板块高角度俯冲、回卷与后撤速率达到了高峰,区域强烈伸展,软流圈物质上涌引起区域快速隆升,导致被动裂谷夭亡.下地壳受上涌软流圈物质加热发生部分熔融,形成的长英质熔体上涌侵位并强烈喷发,裂谷青山期演化为火山弧盆,表现出了一定主动裂谷的特性.综上,灵山岛地区(苏鲁造山带内部)发育莱阳期被动裂谷与青山期火山弧盆(具主动裂谷性质),是从古特提斯构造域向环太平洋构造域转换的记录.苏鲁造山带岩石圈地幔拆沉与软流圈物质上涌是两期裂谷发育、演化的深部动力学机制,裂谷发育演化受到古太平洋板块俯冲、回卷与后撤的远程控制. | 周腾飞 周瑶琪 Nina SØAGER Paul Martin HOLM 张振凯 王俊 梁钊 穆宏玉 程燕君 刘菲菲 王淼 张悦 张卉 辜洋建 董诗绘 赵汉杰 李曼洁 陈扬 刘燕姿 | 2022 | 中国科学:地球科学2022，52，10： | 3 |
| 8 | Reducing the morbidity from extravasation injuries显示文摘 | Khan M S Holmes J D | 2002 | Ann Plast Surg2002，48，6： | 3 |
| 9 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 10 | Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse显示文摘AIM: To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (HPE). METHODS: The stomachs of isourane-anesthetized mice were exteriorized, and the mucosal surface exposed. Blood flow was measured with the laser-Doppler technique, and systemic arterial blood pressure monitored. C57BL/6 mice were exposed to water extract produced from H pylori strain 88-23. To investigate the role of a nerveor iNOS-mediated pathway, we used intraluminal lidocaine and iNOS-/-mice. Blood flow response to the endogenous nitric oxide synthase inhibitor asymmetric dimethyl arginine (ADMA) was also assessed. RESULTS: In wild-type mice, HPE decreased mucosal blood flow by approximately 30%. This reduction was abolished in iNOS-defi cient mice, and by pre-treatment with lidocaine. Luminally applied ADMA resulted in reduction in blood flow similar to that observed in wild-type mice exposed to HPE. CONCLUSION: A H pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways. | Johanna Henriksns Christer Atuma Mia Phillipson Stellan Sandler Lars Engstrand Lena Holm | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 11 | 2010美国心脏病学会基金会/美国心脏学会关于氯吡格雷的应用警告概述显示文摘2010年8月,美国心脏病学会基金会(ACCF)、美国心脏学会(AHA)共同发布了美国食品药品管理局(FDA)关于氯吡格雷的"盒装警告",主要针对医师和患者提出建议,其内容包括:通过检测药物基因型以明确患者氯吡格雷的代谢变化,患者不良反应的风险,基因多态性对氯吡格雷的代谢及临床影响。 | Holmes DR Jr Dehmer GJ Kaul S 黄红娟(译) 卢新政(校) | 2011 | 心血管病学进展2011，32，3： | 2 |
| 12 | The Bioconversion of (3RS,E)-and (3RS, Z)-nerolidol into oxygenated products by streptomyces cinnamonensis 显示文摘 | Holmes D S Ashworth D M | 1990 | Helv Chim Acta1990，73，2： | 2 |
| 13 | Aplication of the zona-free manipulation technique to porcine somatic cell nuclear transfer 显示文摘 | P J Booth S J Tan P Holm | 2001 | Cloning and Stem Cells2001，3，4： | 2 |
| 14 | Heave plate design with computational fluid dynamics 显示文摘 | Holmes S Bhat S Beynet P | 2001 | Journal of Offshore Mechanics and Artic Engineering2001，123，1： | 1 |
| 15 | Double-level cauda equina compression: an experimental study with continuous monitoring of intraneural blood flow in the porcine cauda equina显示文摘 | Takahashi K Olmarker K Holm S | 1993 | J Orthop Res1993，11，1： | 1 |
| 16 | A Unified Approach to Clenshaw Summation and the Recursive Computation of Very High Degree and Order Normalized Associated Legendre Functions显示文摘 | Holmes S A Featherstone W E | 2002 | Journal of Geodesy2002，76，： | 1 |
| 17 | Nutrition of the intervertebral disc:effects induced by vibrations显示文摘 | Holm S Nachemson AL | 1985 | Orthop Trans1985，9，： | 1 |
| 18 | 显示文摘 | Holm R Storp S | 1976 | Journal of Electron Spectroscopy and Related Phenomena1976，8，2： | 1 |
| 19 | Platelet storage lesion in second-generation containers: correlation with platelet ATP levels显示文摘 | Holme S Heaton WA Courtright M | 1987 | Vox Sang1987，53，4： | 1 |
| 20 | Compensatory growth in the rainbow trout, Saimo gairdneri Richardson 显示文摘 | Dobson S H Holmes R M | 1984 | J Fish Biol1984，25，： | 1 |
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