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| 1 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 2 | Relationship between structural abnormalities and short-wavelenth perimetric defects in eyes at risk of glaucoma 显示文摘 | Ugurlu S Hoffman D Garway-Heath DF | 2000 | Am J Ophthalmol2000，129，： | 2 |
| 3 | Metabolic engineering of propanediol pathways显示文摘 | Altaras N E Hoffman M L | 1998 | Biotechnology Progress1998，14，1： | 1 |
| 4 | Ethacrynic acid and piriprost as enhancers ofcytotoxicity in drug resistant and sensitive cell lines显示文摘 | TEW K D BOMBER A M HOFFMAN S J | 1988 | Cancer Res1988，48，： | 1 |
| 5 | An examination of response-surface methodologies for uncertainty analysis in assessment models 显示文摘 | Downing D J Gardner R H Hoffman F O | 1985 | Technometrics1985，27，： | 1 |
| 6 | Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells显示文摘 | Hoffman L Hardej D | 2012 | Environmental Toxicology and Pharmacology2012，34，2： | 1 |
| 7 | Immunofluorometric quantitation and histochemical localiaation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker显示文摘 | Hoffman BR Katsaros D Scorilas A | 2002 | Br J Cancer2002，87，7： | 1 |
| 8 | The effect of cupricion on the radiation grafting of N-vinyl -2-pyrrolidone and hydrophilic monomers onto silicone rubber显示文摘 | RATNER B D HOFFMAN A S | 1974 | J Appl Polym Sci1974，18，27： | 1 |
| 9 | Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines显示文摘 | Tew K D Bomber A M Hoffman S J | 1988 | Cancer Res1988，48，13： | 1 |
| 10 | Solution structure of a conserved domain of antizyme:a protein regulator of polyamines显示文摘 | Hoffman D W Carroll D Martinez N | 2005 | Biochemistry2005，44，11： | 1 |
| 11 | Architecture of the Scalable Communications Core ' s Network on Chip 显示文摘 | Llitzky D A Hoffman J D Chun A | 2007 | Micro IEEE2007，27，5： | 1 |
| 12 | Regime III Crystallization in Melt-Crystallized Polymers: The Variable Cluster Model of Chain Folding 显示文摘 | Hoffman J D | 1983 | Polymer1983，24，1： | 1 |
| 13 | Marketing in hypermedia computer-medi-ated environments:conceptual foundations 显示文摘 | Hoffman D L Novak T P | 1996 | The Journal of Mar-keting1996，，： | 1 |
| 14 | Satellite autonomous navigation-status and history显示文摘 | Chory M A Hoffman D P LeMay J L | 1986 | IEEE Postion Location and Navigaiton Symposium Las Vegas NV Nov 4 - 71986，，： | 1 |
| 15 | Cloning and characterization of Ancylostoma-secreted protein: a novel protein associated with the transition to parasitism hy infective hookworm larvae显示文摘 | Hawdon J M Jones B F Hoffman D R | 1996 | Journal of Biological Chemistry1996，271，： | 1 |
| 16 | Radiation-grafted hydrogels for biomaterial applications as studied by the ESCA technique显示文摘 | RATNER B D WEATHERSBY P K HOFFMAN A S | 1978 | J Appl Polym Sci1978，22，9： | 1 |
| 17 | A typology of retail failures and recoveries显示文摘 | Kelley S W K D Hoffman M A Davis | 1993 | Journal of Retailing1993，69，4： | 1 |
| 18 | Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling 显示文摘 | Hoffman D J Seifert T Borre A Nellans H N | 1995 | Pharm Res1995，12，6： | 1 |
| 19 | Regime Ⅲ crystallization in melt-crystallized polymers:the variable cluster model of chain folding显示文摘 | Hoffman J D | 1983 | Polymer1983，24，1： | 1 |
| 20 | A comparison of methods to test me- diation and other intervening variable effects 显示文摘 | MacKinnon D P Lockwood C M Hoffman J M West S G Sheets V | 2002 | Psychological Methods2002，7，1： | 1 |
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