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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | The Bacillus subtilis chromosome显示文摘 | Henner J Hoch J A | 1980 | Microbiol Rev1980，44，1： | 2 |
| 3 | The Bacillus subtilis chromosome显示文摘 | Henner J Hoch J A | 1980 | Microbiol Rev1980，44，1： | 1 |
| 4 | Matrix-array 3-dimensional echocardiographic assessment of volumes,mass,and ejection fraction in young pediatric patients with a functional single ventricle:a comparison study with cardiac magnetic resonance显示文摘 | Soriano BD Hoch M Ithuralde A | | 0，，： | 1 |
| 5 | Composition controlled spin polarization in Co1-x FexS2 alloys 显示文摘 | C Leighton M Manno A Cady J W Freeland L Wang K Umenoto R M Wentzcovitch T Y Chen C L Chien P L Kuhns M J R Hoch A P Reyes W G Moulton E D Dahlberg J Checkelsky J Eckert | 2007 | Journal of Physics : Condensed Matter2007，19，31： | 1 |
| 6 | Gastroplegia after elective intestinal surgery显示文摘 | Matulikova A Hoch J | 2000 | Rozhl Chir2000，79，3： | 1 |
| 7 | Role of the T cell in the genesis of angiotensin induced hypertension and vascular dysfunction显示文摘 | Guzik T J Hoch N E Brown K A | 2007 | J Exp Med2007，204，10： | 1 |
| 8 | Control of the crystalline quality of wurtzitic GaN films deposited on γ- LiAlO2 by ion-beam assisted molecular-beam epitaxy显示文摘 | Gerlach J W Hofmann A HOche T | 2007 | Nuclear Instrum Methods Phys Res B2007，257，12： | 1 |
| 9 | Differential screening and suppression subtractive hybrization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line显示文摘 | Kuang W W Thompson D A Hoch R V | 1998 | Nucleic Acids Res1998，26，4： | 1 |
| 10 | Matrix-array 3-di- mensional eehocardiographle assessment of volumes, mass, and ejection fraction in young pediatric patients with a func tional single ventricle~ a comparison study with cardiac mag- netic resonance 显示文摘 | Soriano BD Hoch M Ithuralde A | 2008 | Circulation2008，117，14： | 1 |
| 11 | The effect of 3 % and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial显示文摘 | Teunissen J Hochs AH Vaessen-Verberne A | 2014 | Eur Respir J2014，44，4： | 1 |
| 12 | Sequence analysis and regulation of the hpr locus,a regulatory gene for protease production and sporulation in Bacillus subtilis显示文摘 | Perego M Hoch J A | | 0，，： | 1 |
| 13 | Chemotherapy and tar- geted therapy in adenoid cystic carcinoma of the head and neck a review显示文摘 | Papaspyrou G Hoch S Rinaldo A | 2011 | Head Neck2011，33，6： | 1 |
| 14 | Developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms显示文摘 | Stephenson K Hoch J A | | 0，，： | 1 |
| 15 | Calcite crystal growth rate inhibition by polycarboxylicacid显示文摘 | Reddy M M Hoch A R | | 0，，： | 1 |
| 16 | , Buysse D J, Monk T H, Begley A E, Houck P R, Healthy Older Adult's Sleep Predicts All-cause Mortality at 4 to 19 Years of Follow-up 显示文摘 | Dew M A Hoch C C | 2003 | Psychosomatic Medi- cine2003，65，： | 1 |
| 17 | Diverse antibody recognition patterns of the multiple Sm-D antigen polypeptides显示文摘 | HOCH S O ELSENBERG R A SHARP G C | 1999 | Clini Immunol1999，92，2： | 1 |
| 18 | Virulence- and antibiotic resitance- associated two-component signal transduction systems of Gram- positive pathogenic bacteria as targets for antimierobial therapy 显示文摘 | Stephenson K Hoch J A | 2002 | Pharmacol Ther2002，93，： | 1 |
| 19 | Two-component and phosphorelay signal-transduction systems as therapeutic targets显示文摘 | Stephenson K Hoch J A | 2002 | Curr Opin Pharmacol2002，，2： | 1 |
| 20 | Effect of Stage 0 Sporulation Mutations on Subtilisin Expression显示文摘 | Ferrari E Howard S M H Hoch J A | 1986 | J Bacteriol1986，166，： | 1 |
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