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| 1 | Topical application of platelet-rich plasma for diabetic foot ulcers: a systematic review显示文摘AIM To determine if topical application of platelet-rich plasma(PRP) to diabetic foot ulcers(DFUs) results in superior healing rates. METHODS A systematic review was registered with PROSPERO and performed using PRISMA guidelines. Level Ⅰ-Ⅳ investigations of topical PRP application in DFUs were sought in multiple databases including: MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials. The search terms used were 'platelet rich plasma', 'diabetes', 'ulcers', and 'wound'. The Modified Coleman Methodology Score(MCMS) was used to analyze study methodological quality. Study heterogeneity and a mostly non-comparative nature of evidence precluded meta-analysis. Only the outcome measurements used by more than 50% of the studies were included in the data synthesis to increase power of the measurement over that of individual studies. A weighted mean of healing rate per week between PRP group vs controls were compared using two-sample z-tests using P-value of less than 0.05 for significance.RESULTS One thousand two hundred and seventeen articles were screened. Eleven articles(322 PRP subjects, 126 controls, PRP subject mean age 58.4 ± 7.2 years, control mean age 58.7 ± 5.9 years) were analyzed. Six articles were level Ⅱ evidence, four were level Ⅲ, and one article was level Ⅳ. The mean MCMS was 61.8 ± 7.3. Healing rate was significantly faster with PRP application compared to controls(0.68 ± 0.56 cm2/wk vs 0.39 ± 0.09 cm2/wk; P < 0.001). Mean heal time to > 90% of the original ulcer area was 7.8 ± 2.7 wk and 8.3 ± 3.7 wk for patients in the PRP group and control groups, respectively(P = 0.115). There were significantly lower adverse effects reported with PRP application compared to controls(7 wound infections, 1 contact dermatitis vs 14 wound infections, 1 maceration; P < 0.001).CONCLUSION The topical application of PRP for DFUs results in statistically superior healing rates and lower complication rates compared to controls. | Takashi Hirase Eric Ruff Salim Surani Iqbal Ratnani | 2018 | World Journal of Diabetes2018，9，10： | 6 |
| 2 | High cardiovascular risk in severely obese young children and adolescents显示文摘 | Nathalie M A van Emmerik Carry M Renders Marije van de Veer Stef van Buuren Olga H van der Baan-Slootweg Joana E Kist-van Holthe Remy A HiraSing | 2012 | Archives of Disease in Childhood2012，，9： | 2 |
| 3 | Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat显示文摘 | CSICSVARI J HIRASE H CZURKO A | 1998 | Neuron1998，21，1： | 1 |
| 4 | Transformation of cortical and hippocampal neural circuit by environmental enrichment 显示文摘 | Hirase H Shinohara Y | 2014 | Neuroscience2014，210，： | 1 |
| 5 | Anemia and neutropenia in a case of copper deficiency: role of copper in normal hematopoiesis显示文摘 | Hirase N Abe Y Sadamura S | 1992 | Acta Haematol1992，887，： | 1 |
| 6 | Effect of flurazole and other safeners for chloroacetanilide herbicides on cysteine synthase in sorghum shoots显示文摘 | HIRASE K MOLIN W T | 2001 | Pestle Biochem Physiol2001，71，： | 1 |
| 7 | Endothelial dysfunction as a cellular mecha- nism for vascular failure显示文摘 | Hirase T Node K | 2012 | Am J Physiol Heart Circ Physiol2012，302，3： | 1 |
| 8 | Vascular anatomy of the finger dorsum and a new idea for coverage of the finger pulp defect that restores sensation显示文摘 | Endo T Kojima T Hirase Y | 1992 | J Hand Surg Am1992，17，5： | 1 |
| 9 | Double-layered free temporalfascia flap as a two-layered tendon-gliding surface显示文摘 | Hirase Y Kojima T Bang H H | 1991 | Plast Reconstr Surg1991，88，： | 1 |
| 10 | Occludin:a novel integral mem brane protein localizing at tight junctions显示文摘 | Furuse M Hirase T Itoh M | 1993 | J Cell Biol1993，123，6： | 1 |
| 11 | Sulfur assimilation in plants and weed control;Potential targets for novel herbicides and action sites of certain safeners显示文摘 | HIRASE K MOLIN W T | 2003 | Weed Biology and Management2003，3，3： | 1 |
| 12 | Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells显示文摘 | Nishmoto-Hazuku A Hirase T Ide N | 2008 | J Cardiovasc Pharmacol2008，51，3： | 1 |
| 13 | Overexpression of endothelial nitric oxide synthase in endothelial cells is protective against ischemia-reperfusion injury in mouse skeletal musele显示文摘 | OZAKI M KAWASHIMA S HIRASE T | 2002 | Am J Pathol2002，160，4： | 1 |
| 14 | Direct association of occludin with ZO-1and its possible involvement in the localization of occludin at tight junctions显示文摘 | Furuse M Itoh M Hirase T | 1994 | Cell Biol1994，127，6： | 1 |
| 15 | Angiotropic B - cell lymphoa with hemophagocytic syndrome associated with syndrome of inappropriate secretion of antidiuretic hormone 显示文摘 | Watabe R Shibata K Hirase N | 2000 | Ann Hematol2000，79，10： | 1 |
| 16 | Vascular anatomy of the finger dorsum and a new idea for coverage of the finger pulp defect that restores sensation显示文摘 | kojima T Hirase Y | 1992 | J Hand Surg Am1992，17，5： | 1 |
| 17 | Calcium dynamics of cortical astrocytic networks in vivo显示文摘 | Hirase H Qian L Bartho P Buzsaki G | 2004 | PLoS Biol2004，2，4： | 1 |
| 18 | Pathology of superficial sprea-ding type of gastric cancer显示文摘 | Yasui A Hirase Y Miyake M | 1973 | Stomach and Intestine1973，8，： | 1 |
| 19 | Occludin:a novel integral membrane protein localizing at tight junctions显示文摘 | Furusc M Hirase T Itoh M | 1993 | J Cell Biol1993，123，62： | 1 |
| 20 | A versatile one-stage neurovascular flap for fingertip reconstruction:the dorsal middle phalangeal finger flap显示文摘 | Hirase Y Kojima T Matsuura S | 1992 | Plast Reconstr Surg1992，90，： | 1 |
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