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| 1 | New advances in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the leading cause of deaths in cirrhotic patients and the third cause of cancer related deaths.Most HCC are associated withwell known underlying risk factors,in fact,HCC arise in cirrhotic patients in up to 90%of cases,mainly due to chronic viral hepatitis and alcohol abuse.The worldwide prevention strategies are conducted to avoid the infection of new subjects and to minimize the risk of liver disease progression in infected patients.HCC is a condition which lends itself to surveillance as at-risk individuals can readily be identified.The American and European guidelines recommended implementation of surveillance programs with ultrasound every six months in patient atrisk for developing HCC.The diagnosis of HCC can be based on non-invasive criteria(only in cirrhotic patient)or pathology.Accurately staging patients is essential to oncology practice.The ideal tumour staging system in HCC needs to account for both tumour characteristics and liver function.Treatment allocation is based on several factors:Liver function,size and number of tumours,macrovascular invasion or extrahepatic spread.The recommendations in terms of selection for different treatment strategies must be based on evidence-based data.Resection,liver transplant and interventional radiology treatment are mainstays of HCC therapy and achieve the best outcomes in well-selected candidates.Chemoembolization is the most widely used treatment for unresectable HCC or progression after curative treatment.Finally,in patients with advanced HCC with preserved liver function,sorafenib is the only approved systemic drug that has demonstrated a survival benefit and is the standard of care in this group of patients. | Sonia Pascual Iván Herrera Javier Irurzun | 2016 | World Journal of Hepatology2016，8，9： | 51 |
| 2 | 串联直流电弧特性及其在故障诊断中的应用显示文摘直流电弧故障常常会威胁到各种电力电子系统的安全运行,由于其本身的随机性和不稳定性,直流电弧故障很难被有效地检测出来。笔者设计了一套串联直流电弧试验系统用以研究不同因素如负载电流、直流源电压以及电极间隙长度对直流电弧特性的影响。在试验中,负载电流在6~30A之间变化。直流源电压在75~300V之间变化。同时还进行了固定源电压和负载电流下不同间隙长度的试验以研究电孤长度对电弧特性的影响。根据以上试验结果。进行了初步的电弧电压一电流特性的研究。最后.通过对时间窗内电流变化率的分析.研究了电弧电流的脉冲模式。以上研究结果为直流电弧特性研究及直流电弧故障检测提供了重要的基础. | 姚秀 汲胜昌 Luis Herrera 王瑾 | 2012 | 高压电器2012，48，5： | 30 |
| 3 | Human Interaction Dynamics for Its Use in Mobile Robotics:Impedance Control for Leader-follower Formation显示文摘A complete characterization of the behavior in human-robot interactions(HRI) includes both: the behavioral dynamics and the control laws that characterize how the behavior is regulated with the perception data. In this way, this work proposes a leader-follower coordinate control based on an impedance control that allows to establish a dynamic relation between social forces and motion error. For this, a scheme is presented to identify the impedance based on fictitious social forces, which are described by distance-based potential fields.As part of the validation procedure, we present an experimental comparison to select the better of two different fictitious force structures. The criteria are determined by two qualities: least impedance errors during the validation procedure and least parameter variance during the recursive estimation procedure.Finally, with the best fictitious force and its identified impedance,an impedance control is designed for a mobile robot Pioneer 3AT,which is programmed to follow a human in a structured scenario.According to results, and under the hypothesis that moving like humans will be acceptable by humans, it is believed that the proposed control improves the social acceptance of the robot for this kind of interaction. | Daniel Herrera Flavio Roberti Marcos Toibero Ricardo Carelli | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，4： | 8 |
| 4 | Applications of finite element simulation in orthopedic and trauma surgery显示文摘Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied to the correction of deformities, providing the recovering force-displacement and angle-moment curves that characterize the mechanical behavior of the splint in the overall range of movement. | Antonio Herrera Elena Ibarz José Cego?ino Antonio Lobo-Escolar Sergio Puértolas Enrique López Jesús Mateo Luis Gracia | 2012 | World Journal of Orthopedics2012，3，4： | 8 |
| 5 | 各向异性金纳米粒子的制备及其在催化中的应用(英文)显示文摘尽管有关金纳米粒子催化的研究工作很多,但其中大多数都是采用传统的浸渍法将金盐负载到载体上、共沉淀或沉积-沉淀法制得负载的纳米粒子,但这些方法并未吸收最新的纳米技术.最近,金催化剂的研究者开发了在胶态悬浮液中制取金属纳米粒子,然后进行固载,从而使得单金属和双金属催化剂的催化活性和形貌控制取得较大进展.另一方面,最近十年出现了金纳米粒子合成的高级控制技术,得到了许多各向异性的金纳米粒子,且很容易制得新的形貌,可以控制纳米粒子的表面原子配位数和光学特性(可调的等离子体带),这些都与催化密切相关.这些形貌包括纳米棒、纳米星、纳米花、树枝状纳米结构或多面体纳米粒子等.除了高度关注各向异性金纳米粒子的最新开发的制备方法和性质,本综述也清楚地总结了这些纳米粒子独特的催化性能,以及通过提供更高催化性能的金催化剂、控制暴露的活性位,以及热、电和光催化的鲁棒性和可调性,从而给多相催化领域带来令人惊奇的潜在变革. | Peter Priecel Hammed Adekunle Salami Romen Herrera Padilla Ziyi Zhong Jose Antonio Lopez-Sanchez | 2016 | Chinese Journal of Catalysis2016，37，10： | 5 |
| 6 | Male osteoporosis: A review显示文摘Osteoporosis in men is a heterogeneous disease that has received little attention.However,one third of worldwide hip fractures occur in the male population.This problem is more prevalent in people over70 years of age.The etiology can be idiopathic or secondary to hypogonadism,vitamin D deficiency and inadequate calcium intake,hormonal treatments for prostate cancer,use of toxic and every disease or drug use that alters bone metabolism.Risk factors such as a previous history of fragility fracture should be assessed for the diagnosis.However,risk factors in men are very heterogeneous.There are significant differences in the pharmacological treatment of osteoporosis between men and women fundamentally due to the level of evidence in published trials supporting each treatment.New treatments will offer new therapeutic prospects.The goal of this work is a revision of the present status knowledge about male osteoporosis. | Antonio Herrera Antonio Lobo-Escolar Jesús Mateo Jorge Gil Elena Ibarz Luis Gracia | 2012 | World Journal of Orthopedics2012，3，12： | 5 |
| 7 | Medication adherence in schizophrenia显示文摘Non-adherence is a major problem in the treatment of schizophrenia. Its high prevalence, potentially severe consequences and associated costs make the study of this phenomenon a priority issue. In this article, basic non-adherence concepts of prevalence, consequences, evaluation methods, methodological restrictions of available studies, risk factors and intervention strategies, are reviewed. Studying non-adherence risk factors is a necessary step toward designing adequately oriented intervention strategies. An operative definition of adherence and good knowledge of its evaluation methods are essential to study this phenomenon. Unfortunately, most available studies contain methodological restrictions, especially concerning the evaluation methods, and an agreed operative definition of adherence has only very recently been reached. Knowing non-adherence risk factors, intervention strategies and available evidence on their effectiveness is essential in making treatment decisions in daily clinical practice. | Francisco Javier Acosta José Luis Hernández José Pereira Judit Herrera Carlos J Rodríguez | 2012 | World Journal of Psychiatry2012，2，5： | 5 |
| 8 | Biofilm and Helicobacter pylori:From environment to human host显示文摘Helicobacter pylori(H.pylori)is a Gram negative pathogen that selectively colonizes the human gastric epithelium.Over 50%of the world population is infected with H.pylori reaching up to 90%of infected individuals in developing countries.Nonetheless the increased impact upon public health care,its reservoir and the transmission pathway of the species has not been clearly established yet.Molecular studies allowed the detection of H.pylori in various aquatic environments,even forming biofilm in tap water distribution systems in several countries,suggesting a role of water as a possible reservoir of the pathogen.The persistence of human infection with H.pylori and the resistance of clinical isolates to commonly used antibiotics in eradication therapy have been related to the genetic variability of the species and its ability to develop biofilm,demonstrated both in vivo and in vitro experiments.Thus,during the last years,experimental work with this pathogen has been focused in the search for biofilm inhibitors and biofilm destabilizing agents.However,only two anti-H.pylori biofilm disrupting agents have been successfully used:Curcumin-a natural dye-and N-acetyl cysteine-a mucolytic agent used in respiratory diseases.The main goal of this review was to discuss the evidences available in the literature supporting the ability of H.pylori to form biofilm upon various surfaces in aquatic environments,both in vivo and in vitro.The results published and our own observations suggest that the ability of H.pylori to form biofilm may be important for surviving under stress conditions or in the spread of the infection among humans,mainly through natural water sources and water distribution systems. | Apolinaria García María José Salas-Jara Carolina Herrera Carlos González | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 9 | The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines显示文摘One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition(EMT)program which has been associated with chemoresistance in tumoral cells.The transcription factor zinc finger E-box-binding homeobox 1(ZEB1),a key EMT activator,has recently been related to docetaxel resistance,the main chemotherapeutic used in advanced prostate cancer treatment.The mechanisms involved in this protective effect are still unclear.In a previous work,we demonstrated that ZEB1 expression induced an EMT-like phenotype in prostate cancer cell lines.In this work,we used prostate cancer cell lines 22Rvl and DU145 to study the effect of ZEB1 modulation on docetaxel resistance and its possible mechanisms.The results showed that ZEB1 overexpression conferred to 22Rvl cell resistance to docetaxel while its silencing made DU145 cells more sensitive to it.Analysis of resistance markers showed no presenee of ATP-binding cassette subfamily B member 1(MDR1)and no changes in breast cancer resistance protein(BCRP)or ATP-binding cassette subfamily C member 10(MRP7).However,a correlation between ZEB1,multidrug resistance-associated protein 1(MRP1),and ATP-binding cassette subfamily C member 4(MRP4)expression was observed.MRP4 inhibition,using MK571,resensitized cells with ZEB1 overexpression to docetaxel treatment.In addition,modulation of ZEB1 and subsequent change in MRP4 expression correlated with a lower apoptotic response to docetaxel,characterized by lower B-cell lymphoma 2(Bcl2),high BCL2-associated X protein(Bax),and high active caspase 3 expression.The response to docetaxel in our model seems to be mediated mainly by activation of the apoptotic death program.Our results showed that modulation of MRP4 could be a mediator of ZEBl-related resistance to docetaxel in prostate cancer,making it a possible marker for chemotherapy response in patients who do not express MDR1. | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，5： | 5 |
| 10 | 《口腔健康和全身健康:牙周病预防和管理的白皮书》(一)牙周病为什么重要?显示文摘本白皮书为口腔卫生专业人员提供了全面而简单的综述.内容涉及牙周病的全球患病率及影响、病因、发病机制、预防、诊断和治疗等主要问题。明确了解决牙周病负担所面临的关键挑战.为口腔卫生专业人员、决策者和其他相关实施人员提供了行动计划。前言明确了牙周疾病的定义和相关症状、体征.包括菌斑性龈炎:即有牙龈炎症但不伴有临床附着丧失;牙周炎:有牙龈炎症同时伴有临床附着丧失及牙槽骨吸收。值得注意的是.牙周炎是全球成年人牙齿丧失和牙列缺损的主要原因。本部分介绍了目前牙周疾病的分类(1999年分类).简要介绍了在2017年11月举行的牙周世界联合研讨会达成.于2018年发布的关于牙周和种植体周病和状态新分类的共识.并强调牙科专业人士在评估患者牙周状况时应遵循的筛选和诊断程序。这些程序包括医学和牙科病史/危险因素问题、口内外检查、影像学评估和牙周专科检查。第二部分详细介绍了牙周病的病因和发病机制.描述了致病因素口腔菌斑生物膜引起的的宿主炎症反应过程。还涉及牙周病的危险因素.包括可改变的(生活方式.代谢.饮食.社会经济和压力)和不可改变的(遗传特征、性别.年龄和某些系统状态)风险因素。第三至第五部分讨论了牙周病的重要性。总结了牙周病的流行病学和全球负担.重度牙周炎被认为是世界第六大流行疾病或状态。牙周病患病率随年龄增长而增加,并且存在地域差异性。强调了牙周病具有重要的社会经济影响(第三部分)。第四部分描述了牙周炎导致菌血症和全身炎症水平增加的过程.以及与其他慢性非传染性疾病(NCDs)共有的不健康的生活方式(例如吸烟)、代谢和饮食危险因素。第五部分强调了牙周炎的后果和影响。在第四部分内容的基础上.叙述了与牙周感染和炎症相关的系统性疾病或状况、如糖尿病和心血管病。该部分还阐述了牙周炎通过损害社交.功能和美学从而对患者的生活质量和自尊产生显著影响。 | David Herrera Jorg Meyle Stefa n Renvert Lijian Jin 国际牙科联盟(FDI) 全球牙周健康项目工作组 | 2019 | 中国口腔医学继续教育杂志2019，22，1： | 4 |
| 11 | The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines显示文摘 | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2018 | Asian Journal of Andrology2018，20，3： | 4 |
| 12 | Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia显示文摘AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar metaplasia.METHODS: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by PCR.RESULTS: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection. | Roberto Herrera-Goepfert Luis F Onate-Ocana José Luis Mosqueda-Vargas Luis A Herrera Clementina Castro Julia Mendoza Rodrigo González-Barrios | 2016 | World Journal of Gastroenterology2016，22，18： | 3 |
| 13 | Wavelet-based deconvolution of ultrasonic signals in nondestructive evaluation显示文摘In this paper, the inverse problem of reconstructing reflectivity function of a medium is examined within a blind deconvolution framework. The ultrasound pulse is estimated using higher-order statistics, and Wiener filter is used to obtain the ultrasonic reflectivity function through wavelet-based models. A new approach to the parameter estimation of the inverse filtering step is proposed in the nondestructive evaluation field, which is based on the theory of Fourier-Wavelet regularized deconvolution (ForWaRD). This new approach can be viewed as a solution to the open problem of adaptation of the ForWaRD framework to perform the convolution kernel estimation and deconvolution interdependently. The results indicate stable solutions of the esti- mated pulse and an improvement in the radio-frequency (RF) signal taking into account its signal-to-noise ratio (SNR) and axial resolution. Simulations and experiments showed that the proposed approach can provide robust and optimal estimates of the reflectivity function. | HERRERA Roberto Henry OROZCO Rubén RODRIGUEZ Manuel | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，10： | 2 |
| 14 | Integrating three representation models in fuzzy multipurpose decision making based on fuzzy preference relations 显示文摘 | Chiclana F Herrera F Herrera-Viedma E | 1998 | Fuzzy Sets and Systems1998，97，： | 2 |
| 15 | Integrating multiplicative preference relations in a multipurpose decision-making model based on fuzzy preference relations显示文摘 | Chiclana F Herrera F Herrera-Viedma E | 2001 | Fuzzy Sets and Systems2001，122，2： | 2 |
| 16 | Some issues on consistency of fuzzy preference relations显示文摘 | E. Herrera-Viedma F. Herrera F. Chiclana M. Luque | 2002 | European Journal of Operational Research2002，，1： | 2 |
| 17 | Phylogeny and subgeneric classification of Bouteloua with a new species,B. herrera-arrietae (Poaceae: Chloridoideae: Cynodonteae: Boutelouinae)显示文摘Bouteloua (Poaceae:Chloridoideae:Cynodonteae;Boutelouiane ) 牧草草的一个重要的类正在包含在北墨西哥与差异的一个中心首先在美洲发现的 60 种类。一个现代 subgeneric 分类正在缺乏。我们的学习的目标是重建在用有与以前的研究相比的增加的种类采样的分子的数据的 Bouteloua 的种类之中的进化历史。种系发生的分析在 209 件样品, 59 种类(206 个个人) 在 Bouteloua 是上被进行,用二质体(rpl32-trnL 分隔符和 rps16-trnK 分隔符) 并且原子它的 1 &2 (ribosomal 内部抄录分隔符) 推断进化关系并且生产一个 subgeneric 分类的序列。总的来说,它的 and 质体发展史显示了类似的模式。然而, ITS 发展史缺乏脊梁结构,恢复仅仅从九的四内部 clades 在质体发展史发现。它的网络显示出一个放射的进化模式并且显示很多个不兼容的裂口,经过在不同的节的种类之间的杂交建议。从联合质体和它的区域的最大可能性的的树很好被决定并且描绘包括十强烈支持的 clades 和一中等支持的 clade 的强烈支持的 monophyletic Bouteloua。分子的结果在 Bouteloua s.l 以内支持 10 节和二个分部的识别;三节是新的:Barbata, Hirsuta,和 Trifida;四节是新联合:Buchloe, Cyclostachya, Opizia,和 Triplathera;并且二个分部是新的:Eriopoda 和 Hirsuta。基于我们的分子的结果和我们描述的独特词法人物的拥有从 Nuevo León 的新种, Bouteloua herrera-arrietae。 | Paul M. Peterson Konstantin Romaschenko Yolanda Herrera Arrieta | 2015 | Journal of Systematics and Evolution2015，53，4： | 2 |
| 18 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 19 | Adsorption of Salmonella enteritidis by cetylpyridinium exchanged montmorillonite clays显示文摘 | HERRERA P BURGHARDY R C PHILLIPS T D | 2000 | Microbiology2000，74，： | 2 |
| 20 | Good results with unreamed nail and bone grafting for humeral nonunion显示文摘 | ángel A Martínez Antonio Herrera Jorge Cuenca | 2002 | Acta Orthopaedica2002，，3： | 2 |
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