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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans显示文摘尽管精子在睾丸在精子发生期间被形成,阴囊的精子是不成熟的并且不能游泳或使肥沃。这些批评精子的功能在特定的钠环境被 theblood-epididymal 障碍创造的附睾被获得;附睾主细胞分泌的蛋白质把精子绑在成熟并且调整精子的 maturational 过程。在附睾, epithelialcell 房间相互作用被粘住的连接调停,为房间粘附必要,并且由紧密的连接,哪个形式 blood-epididymal 障碍。这些细胞的连接的规定被认为在在邻近的主细胞许可证之间的 epididymis.Tight 连接以内在精子成熟的过程代表一个关键决定因素在为精子成熟是必要的附睾的腔的特定的微型环境的形成。尽管我们成为了重要,在理解附睾功能和 blood-epididymal 障碍进行,用动物模型,人的附睾上有有限信息。如果我们将理解对人的附睾可归因的正常、病理学的条件工作,我们必须清楚地建立人的附睾的生理、细胞、分子的规定,描绘这些功能并且开发将使用 epididymalfunctions 到的临床的策略的 develop 工具改进不孕的处理。 | Daniel G. Cyr Mary Gregory Evemie Dube Julie Dufresne Peter T. K. Chan Louis Hermo | 2007 | Asian Journal of Andrology2007，9，4： | 3 |
| 3 | Circulating levels of nitrated apolipoprotein A-1 are increased in type 2 diabetic patients显示文摘 | Hermo R Mier C Mazzotta M | 2005 | Clin Chem Lab Med2005，43，6： | 1 |
| 4 | The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat显示文摘 | Levy S Serre V Hermo L | 1999 | J Androl1999，20，3： | 1 |
| 5 | Shiga toxin-producing Escherichia coli in children: diagnosis and clinical manifestations of O157:H7 and non-O157:H7 infection显示文摘 | HERMOS C R JANINEH M HAN L L | 2011 | Journal of Clinical Microbiology2011，49，3： | 1 |
| 6 | Ischemia-modified albumin levels in cord blood:a case-control study in uncomplicated and complicated deliveries显示文摘 | Hermo R Monroy C | 2005 | Clin Chem Acta2005，362，1： | 1 |
| 7 | Hydrotalcite as sorbent for trinitrophenol sorption capacity and mechanism显示文摘 | Hermosín M C Pavlovic I Ulibarri M A Cornejo J | 1996 | Water research1996，30，1： | 1 |
| 8 | Improved determination of quin- olones in milk at their MRL levels using LC-UV,LC-FD,LC-MS and LC- MS/MS and validation in line with regulation 2002/657/EC显示文摘 | HERMO M P NEMUTLU E KIR S | 2008 | Analytica Chimica Acta2008，613，： | 1 |
| 9 | Surfing the wave,cycle,life history,and genes/proteins expressed by testicular germ cells显示文摘 | Hermo L Pelletier RM Cyr DG | 2010 | Microsc Res Tech2010，73，4： | 1 |
| 10 | Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients S显示文摘 | HERMOS JA YOUNG MM GAGNON DR | 2004 | Areh Intern Med2004，164，21： | 1 |
| 11 | Immunolocalization and regulationof cystic fibrosis transmembrane conductance regulator in theadult rat epididymis显示文摘 | Ruz R Andonian S Hermo L | 2004 | J Androl2004，25，： | 1 |
| 12 | Hermansky-Pudlak syndrome type 1:gene organization,novel mutations,and clinical-molecular review of non-Puerto Rican cases显示文摘 | Hermos CR Huizing M Kaiser-Kupfer MI | 2002 | Hum Mutat2002，20，6： | 1 |
| 13 | De-velopment of analytical methods for multiresidue determination of quinolones in pig muscle samples by liquid chromatography with ultraviolet detec-tion,liquid chromatography-mass spectrometry and liquid chromagraphy-tandem mass spectrome-try显示文摘 | HERMO M P BARRON D BARBOSA J | 2006 | J Chromatogr A2006，1104，： | 1 |
| 14 | High levels of antibody to Panton-Valentine leukocidin are not associated with resistance to Staphylococcus aureus-associated skin and soft-tissue infection 显示文摘 | Hermos CR Yoong P Pier GB | 2010 | Clin Infect Dis2010，51，10： | 1 |
| 15 | Characterizations of long term oxycodone/acet- aminophen prescriptions in veteran pations 显示文摘 | Hermos JA Young MM Gagnon DR | 2004 | Archives of Internal Medicine2004，164，21： | 1 |
| 16 | Proton pump inhibitor discontinuation in long-term care 显示文摘 | Linsky A Hermos JA Lawler EV | 2011 | J Am Geriatr Soc2011，59，9： | 1 |
| 17 | Improved determination of quinolones in milk at their MRL levels using LC-UV, LC-FD, LC-MS and LC-MS/MS and validation in line with regulation 2002/657/EC显示文摘 | HERMO M P NEMUTLU E KIR S | 2008 | Analytica Chimica Acta2008，613，1： | 1 |
| 18 | Ischemia-modified albumin levels in cord blood:a case-control study in uncomplicated and complicated deliveries显示文摘 | Gugliucci A Hermo R Monroy C | 2005 | Clin Chim Acta2005，362，12： | 1 |
| 19 | Determination of residues of quinolones in pig muscle:Comparative study of classcal and microwave extraction techniques显示文摘 | Hermo M P Barron D Barbosa J | 2005 | Analytica Chimica Acta2005，539，12： | 1 |
| 20 | Simultaneous determina- tion and toxicology assessment of penicillins in different water matri- ces显示文摘 | Tong L Wang YX Pilar Hermo M | 2014 | Ecotoxicology2014，23，10： | 1 |
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