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| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | 用RFLP方法研究陕西省主要小麦品种遗传多样性及其演变显示文摘研究用RFLP方法,对我国主要小麦产区,陕西省40年代以来广为种植的小麦品种的遗传多样性进行了研究,结果表明,占总带数26.2%的HINDII酶的RFLP带具有遗传多态性。24个小麦品种平均遗传相似系数为0.948。53.8%的探针显示了多态性。平均多态性信息含量指数为0.252。陕西省小麦品种遗传多样性以70年代为最高,之后开始降低。 | 朱列层 唐国顺 HAZEN S P KIM H S WARD R W | 1999 | 西北植物学报1999，19，2： | 11 |
| 3 | Data-Driven Discovery in Mineralogy: Recent Advances in Data Resources, Analysis, and Visualization显示文摘Large and growing data resources on the diversity, distribution, and properties of minerals are ushering in a new era of data-driven discovery in mineralogy. The most comprehensive international mineral database is the IMA database, which includes information on more than 5400 approved mineral species and their properties, and the mindat.org data source, which contains more than 1 million species/locality data on minerals found at more than 300 000 localities. Analysis and visualization of these data with diverse techniques—including chord diagrams, cluster diagrams, Klee diagrams, skyline diagrams, and varied methods of network analysis—are leading to a greater understanding of the co-evolving geosphere and biosphere. New data-driven approaches include mineral evolution, mineral ecology, and mineral network analysis—methods that collectively consider the distribution and diversity of minerals through space and time. These strategies are fostering a deeper understanding of mineral co-occurrences and, for the first time, facilitating predictions of mineral species that occur on Earth but have yet to be discovered and described. | Robert M. Hazen Robert T. Downs Ahmed Eleish Peter Fox Olivier C. Gagné Joshua J. Golden Edward S. Grew Daniel R. Hummer Grethe Hystad Sergey V. Krivovichev Congrui Li Chao Liu Xiaogang Ma Shaunna M. Morrison Feifei Pan Alexander J. Pires Anirudh Prabhu Jolyon Ralph Simone E. Runyon Hao Zhong | 2019 | Engineering2019，5，3： | 2 |
| 4 | The role of myeloperoxidase in the pathogenesis of coronary artery disease显示文摘 | Nicholls SJ Hazen SL | 2004 | Jpn J Infect Dis2004，57，5： | 1 |
| 5 | Temperature-insensitive near-infrared spectro scopic measurement of glucose in aqueous solutions显示文摘 | Hazen Kevin H Arnold Mark A Small Gary W | 1994 | Applied Spectroscopy1994，48，4： | 1 |
| 6 | Poland's syndrome and carcinoma of the breast: a case report显示文摘 | Katz SC Hazen A Colen SR | 2001 | Breast J2001，7，1： | 1 |
| 7 | The role of myeloperoxidase in the pathogenesis of coronary artery disease显示文摘 | Nicholls SJ Hazen SL | 2004 | Jpn J Infect Dis2004，57，5： | 1 |
| 8 | Participation of yeast cell surface hydrophobicity in ad?herence of Candida albicans to human epithelial cells显示文摘 | Hazen K C | 1989 | Infect Im?mun1989，57，7： | 1 |
| 9 | My eloperoxidase, modiH ed lipoproteins and atherogenesis显示文摘 | Nicholls SJ Hazen SL | 2009 | J Lipid Res2009，50，： | 1 |
| 10 | Adult mice generated from induced pluripotent stem cells显示文摘 | Poland M J Hazen J L Nazor K L | 2009 | Nature2009，461，7260： | 1 |
| 11 | Tidal currents and eddy statistics from iceberg trajectories off Labrador显示文摘 | GARRETT C J R MIDDLETON J HAZEN M | 1985 | Science1985，227，： | 1 |
| 12 | Preparation of site-specifically labeled fluorinated proteins for 19F NMR structural characterization显示文摘 | Hammill J T Miyake-Stoner S Hazen J L et at | 2007 | Nat Protoc2007，2，10： | 1 |
| 13 | Hydrothermal reactions of pyruvie acid: synthesis, selection, and self-assembly of am- phiphilic molecules显示文摘 | HAZEN R M DEAMER D W | 2007 | Orig Life Evol Biosph2007，37，2： | 1 |
| 14 | Myeloperoxidase and cardiovascular disease显示文摘 | Nicholls SJ Hazen SL | 2005 | Arterioscler Thromb Vasc Biol2005，25，6： | 1 |
| 15 | The dy- namic behavior of ballistic gelatin显示文摘 | Shephert C J Appleby-Thomas G J Hazen P J | 2009 | AlP Conference Proceed- ings2009，1195，： | 1 |
| 16 | General anesthesia and elderly surgical patients显示文摘 | Hazen SE Larsen PD Martin JLH | 1997 | Aorn Journal1997，，04： | 1 |
| 17 | Autologous fat grafting and Facial reconstruction显示文摘 | Wetterau M Szpalski C Hazen A | 2012 | J Craniofac Surg2012，23，1： | 1 |
| 18 | Elevated levels of protein-bound p-hydroxyphenylacetald-ehyde,an aminoacid-derived aldehyde generated by myeloperoxidase,are present in human fatty streaks,intermediate lesions and advanced atherosclerotic lesions 显示文摘 | HAZEN S L GAUT J P CROWLEY J R | 2000 | Biochem2000，3523，： | 1 |
| 19 | Participation of yeast cell surface hydrophobicity in adherence of Candida albican to human epithelia cell显示文摘 | Hazen KC | 1989 | Infect Immun1989，57，： | 1 |
| 20 | Robust speaker recognition in noisy conditions显示文摘 | Ming J Hazen T J Glass J R | 2007 | IEEE Trans Au- dio Speech Lang Process2007，15，5： | 1 |
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