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| 1 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 2 | The effect of combination treatment with acarbose and glibenclamide on post glucose and insuin profiles: Additive glucose lowering effect and decreased hypoglycaemia显示文摘 | Rosak C Haupt E Walter J | 2002 | Diabetes Nutr Metab2002，15，3： | 1 |
| 3 | A new effect of dy- namic polarization in a solid obtained by rapid change oftemperaturefJ显示文摘 | Yilxnaz E Haupt K Mosbaeh K | 2000 | Physics Letters A2000，39，： | 1 |
| 4 | The effect of combination treatment with acarbose and glibenclamide on postprandial glucose and insulin profiles:additive blood glucose lowering effect and decreased hypoglycemia显示文摘 | Rosak C Haupt E Walter T | 2002 | Diabetes Nutr Metab2002，15，3： | 1 |
| 5 | Structural characterisation of hurnic acid-bound PAH residues in soil by 13C-CPMAS-NMR-spectroscopy:evidence of covalent bonds显示文摘 | Kacker T Haupt E Garms C Francke W Steinhart H | 2002 | Chemosphere2002，48，1： | 1 |
| 6 | Guidelines on critical care services and personnel:recommendations based on a system of categorization of three levels of care显示文摘 | Haupt M T Bekes C E Brilli R J | 2003 | Crit Care Med2003，31，11： | 1 |
| 7 | Probing the Recognition Specificity of a Protein Molecularly Imprinted Polymer Using Force Spectroscopy 显示文摘 | Kirat K E Bartkowski M Haupt K | 2009 | Biosens Bioelectron2009，24，8： | 1 |
| 8 | Development of a recombinant truncated nucleocapsid protein based immunoas- say for detection of antibodies against human coronavirus OC43显示文摘 | Blanchard E G Miao C Haupt T E et at | 2011 | J Virol Methods2011，177，1： | 1 |
| 9 | Influence of functional and cross-linking monomers and the amount of template on the performance of molecularly imprinted polymers in binding as- says显示文摘 | Yilmaz E Mosbach K Haupt K | 1999 | Anal Commun1999，36，5： | 1 |
| 10 | Validation of a receptor-dispersion model coupled with a genetic algorithm using synthetic data显示文摘 | Haupt S E Young G S Allen G T | 2006 | Journal of Applied Meteorology and Climatology2006，45，3： | 1 |
| 11 | Improving pollutant source characterization by better estimating wind direction with a genetic algorithm显示文摘 | Allen C T Young G S Haupt S E | 2007 | Atmospheric Environment2007，41，11： | 1 |
| 12 | The effect of combination treatment with acarbose and glibenclamide on postprandial glucose and insulin profiles:additive blood glucose lowering effect and decreased hypoglycaemia显示文摘 | Rosak C Haupt E Walter T | | 0，，03： | 1 |
| 13 | Fluid loading increases oxygen consumption in septic patients with lactic acidosis显示文摘 | Haupt M T Gilbert E M Carlson R W | 1985 | Am Rev Respir Dis1985，131，： | 1 |
| 14 | The effect of combination treatment with aearbose and glibenelamide on post glucose and insuin profiles: additive glucose lowering effect and decreased hypoglyeaemia 显示文摘 | Rosak C Haupt E Walter J | 2002 | Diabetes Nutr Metab2002，15，3： | 1 |
| 15 | Relationship between age at time of cataract extraction and time interval before capsulotomy for opacification显示文摘 | Maltzman BA Haupt E Notis C | 1989 | Ophthalmic Surg1989，20，： | 1 |
| 16 | Validation of a receptor/dispersion model coupled with a genetic algorithm using synthetic data 显示文摘 | Haupt S E Young G S Allen C T | 2005 | Journal of Applied Meteorology and dimatology2005，45，： | 1 |
| 17 | On the DynamicBehaviour of Polymers under Finite Strains:Constitutive Modelling and Identification ofParameters 显示文摘 | Haupt P Lion A Backhaus E | 2000 | International Journal of Solidsand Structures2000，37，26： | 1 |
| 18 | Source characterization with a genetic algorithm-coupled dispersion-backward model in corporating SCIPUFF显示文摘 | Allen C T Haupt S E Young G S | 2007 | Journal of Applied Meteorology and Climatology2007，46，： | 1 |
| 19 | Relationship between age at time of cataract extraction and time interval for capsulotomy for opacification 显示文摘 | Maltzman BA Haupt E Notis C | 1989 | Ophthalmic Surg1989，20，5： | 1 |
| 20 | Influence of functional and cross - linking monomers and the amount of template on the performance of molecularly imprinted polymers in binding assays显示文摘 | Yilmaz E Mosbach K Haupt K | 1999 | Anal Commun1999，36，： | 1 |
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