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226篇 您的检索式：作者名="HART M K"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘	Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington	2001	Human Pathology2001，，4：	3
3	Vibration analysis of circtdar Mindlin plates using the differential quadrature method显示文摘	Liew K M Hart J B Xiao Z M	1997	Journal of Sound and Vibration1997，205，5：	1
4	The effect of model similarity on girl's motor performance 显示文摘	Meaney K S Griffin L K Hart M A	2005	Journal of Teaching Physical Education2005，24，：	1
5	Endovascular therapy as the primary approach for limb salvage in patients with critical limb is- chemia:experience with 443 infrapopliteal procedures显示文摘	Bosiers M Hart JP Deloose K	2006	Vascular2006，14，2：	1
6	Chaotic fluctuation in natural wind and its application to thermal amenity 显示文摘	Hart T Shimizu M Iguch K	1997	Nonlinear Analysis Theory Methods & Application1997，30，5：	1
7	Primitive neuroectodermal tumours of the brain in children显示文摘	Hart M N Earle K M	1973	Cancer1973，32，4：	1
8	Plant extracts to manipulate rumen fermentation显示文摘	HART K J YáEZ-RUIZ D R DUVALET S M	2007	Animal Feed Science and Technology2007，147，123：	1
9	Plant extracts to manipulate rumen fermentation 显示文摘	Hart K J Y'ancz-Ruiz D R Duvalet S M	2007	Animal Feed Science and Technology2007，147，13：	1
10	Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘	Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W	2001	Analytica Chimica Acta2001，444，1：	1
11	Chaotic fluctuation in natural wind and its application to thermal amenity 显示文摘	Hart T Shimizu M Iguch K	1997	Nonlinear Analysis Theory Methods & Applica- tion1997，30，5：	1
12	Repeat neuroimaging of mild traumatic brain injured patients with acute traumatic intracranial hemorrhage: clinical outcomes and radiographic features显示文摘	Kreitzer N Lyons M S Hart K	2014	Acad Emerg Meal2014，21，10：	1
13	Endovascular therapy as the primary approach for limb salvage in patients with critical limb ischemia: experience with 443 infrapopliteal procedures 显示文摘	Bosiers M Hart JP Deloose K	2006	Vascular2006，14，2：	1
14	Surface modification for adhesion enhancement of PET-laminated steel using atmospheric pressure plasma 显示文摘	Hart M H Jegal J P Park K W	2007	Surface & Coatings Technology2007，201，：	1
15	IL-8 in sepsis: relation to shock and inflammatory mediators 显示文摘	Hack C E Hart M Strack van Schijadel K J M	2002	Infection and Immunity2002，60，：	1
16	Primitive neuroectodermal tumors of the brain in children显示文摘	Hart M N Earle K M	1973	Cancer1973，32，4：	1
17	Preclinical efficacy and safety of pascolizumab (SB 240683):A humanized anti-interleukin-4 antibody with therapeutic potential in asthma显示文摘	Hart T K Blackburn M N Brigham-Burke M	2002	Clin Exp Immunol2002，130，：	1
18	The mode of action of the Bacillus thuringiensis vegetative insecticidal protein Vip3A differs from that of Cry1Ab delta-endotoxin显示文摘	Lee M K Walters F S Hart H	2003	Applied and Environmental Microbiology2003，69，46：	1
19	Primitive neuroectodermat tumors of the brain in children 显示文摘	Hart M N Earle K M	1973	Cancer1973，32，4：	1
20	The transcription fac- tor PLZF directs the effeetor program of the NKT cell lineage显示文摘	Savage A K Constantinides M G Hart J	2008	Im- munity2008，29，3：	1

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