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| 1 | Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs显示文摘Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic medium.Results from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-MSCs.Interestingly,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis methods.Lastly,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and senolytics.The results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in cartilage.The P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans. | Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 2 | Production of carotenoids by Rhodotorula rubra from sauerkraut brine 显示文摘 | Shin G T Hang Y D | 1996 | Lebensm - Wiss u - Technol1996，29，： | 1 |
| 3 | Changes in brain GnRH associated withphotorefractoriness in house sparrows (Passer domesticus) 显示文摘 | Hang T P Ball G F | 1995 | General Comp Endocrinol1995，99，： | 1 |
| 4 | Air flow and particletransport in a triDoelectric coal/asii cleaning system-counter flowing straight duct design显示文摘 | Ahmadi G Chunghong H Hang B | 2000 | Particulate Science& Technolog2000，18，3： | 1 |
| 5 | Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis显示文摘 | lizuka K Bruick R K Hang G | 2004 | PNAS2004，101，19： | 1 |
| 6 | Rapid changes in the hydrologic cycle of the tropical Atlantic during the last glaeial显示文摘 | Peterson L C Hang G H Hughen K A | 2000 | Science2000，290，： | 1 |
| 7 | Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model:a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO)显示文摘 | Shi JX Hang CH | 2007 | Neurosci Lett2007，425，： | 1 |
| 8 | Dogs cloned from fetal fibroblasts by nuclear transfer显示文摘 | Hang S G Jang G Kim M K | 2009 | Anim Reprod Sci2009，115，1234： | 1 |
| 9 | Self-tuning Smith Predictors for Processes with Long Dead Time显示文摘 | Hang C C Wang Q G Cao L S | 1995 | Int J Adaptive Control and Signal Processing1995，9，3： | 1 |
| 10 | Wavelet analysis of sensor signals for tool condition monitoring: a review and some new results显示文摘 | Zhu K San W Y Hang G S | 2009 | International Journal of Machine Tools & Manufacture2009，49，78： | 1 |
| 11 | Process Frequency Response Estimation from Relay Feedback显示文摘 | Wang Q G Hang C C Bi Q | 1997 | Control Engineering Practice1997，5，9： | 1 |
| 12 | A nanoliter-scale nucleic acid processor with parallel architecture显示文摘 | Hong J W Studer V Hang G | 2004 | Nature Biotechnology2004，22，： | 1 |
| 13 | Europ Polym J显示文摘 | Xu W B Liang G D Zhai H B Tang S P Hang G P Pan W P | 2003 | 39:1 4672003，39，： | 1 |
| 14 | Optimal filtering for linear discr te-time systems with single delayed measurement 显示文摘 | Zhao H G Z hang H S Zhang C H | 2008 | International Journal of Control Automation and Systems2008，6，3： | 1 |
| 15 | Different Distribution of HIV-I Sub- type and Drug Resistance Were Found among Treatment Naive In- dividuals in Henan, Guangxi, and Yunnan Province of China 显示文摘 | H L Sun G Hang S et ol | 2013 | PLoS One2013，8，75： | 1 |
| 16 | Simultaneous removal of NO and carbon particulates over lanthanoid perovskite-type catalysts 显示文摘 | Hang S S Lee G D | 2000 | Catalysis Today2000，63，2： | 1 |
| 17 | Embedded SMA wire actuated biomimetic fin:a module for biomimetic underwater propulsion显示文摘 | Wang Z L Hang G R Wang Y W | 2008 | Smart Materials and Structures2008，17，2： | 1 |
| 18 | Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat显示文摘 | HANG RL CHOPP M LI G | 1994 | Neurology1994，44，： | 1 |
| 19 | Flavonoids of Limonium aureum 显示文摘 | Ye G Hang CG | 2006 | Chemistry of natural compounds2006，42，2： | 1 |
| 20 | IMC-based control system design for unstable processes显示文摘 | Yang X P Wang Q G Hang C C | 2002 | Industrial Engineering & Chemical Research2002，41，17： | 1 |
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