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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Selected contribution:acute cellular and molecular responses to resistance exorcise显示文摘 | Haddad F Adams G R | 2002 | J Appl Physiol2002，93，1： | 1 |
| 3 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 4 | Docetaxel,cisplatin,5-fluorouracil (TPF)-based induction chemotherapy for head and neck cancer and the case for sequential,combined-modality treatment显示文摘 | Haddad R Tishler R B Norris C M | 2003 | Oncologist2003，8，1： | 1 |
| 5 | The modulato- ry effect of leptin on the overall insulin production in ex-vivo normal rat pancreas 显示文摘 | Haddad N Howland R Baroody G | 2006 | Canadian Journal of Physiology and Pharmacology2006，84，2： | 1 |
| 6 | 显示文摘 | BREADMORE M C MACKA M HADDAD P R | 1999 | Electrophoresis1999，20，10： | 1 |
| 7 | Optimum dietary crude protein level for finishing Awassi lambs显示文摘 | Haddad S G Nasr R E Muwalla M M | 2001 | 39(1): 41-462001，39，1： | 1 |
| 8 | Utero-vaginal anast- omosis in women with uterine cervix atresia: Long-term follow- upand reproductive performance a study of 18cases 显示文摘 | Deffarges JV Haddad B Musset R | 2001 | Hum Reprod2001，16，8： | 1 |
| 9 | Primary pulmonary paraganglioma:case report andliterature review显示文摘 | da Silva R A Gross J L Haddad F J | | 0，，： | 1 |
| 10 | 查看详情显示文摘 | Shaw M J Haddad P R | | 0，，03： | 1 |
| 11 | Novel finding of carbamazepine induced gall bladder granulomatous vasculitis显示文摘 | Haddad R O'Brien B Evans J | 2014 | Intern Med J2014，44，7： | 1 |
| 12 | Predicting the potential distribution of the alien invasive American bullfrog(Lithobates catesbeianus)in Brazil显示文摘 | GIOVANELLI J G R HADDAD C F B Alexandrino J | 2008 | Biological Invasions2008，10，： | 1 |
| 13 | Influence of locking stitch size in a four-strand cross-locked cruciate flexor tendon repair显示文摘 | Peltz TS Haddad R Scougall PJ | 2011 | J Hand Surg Am2011，36，3： | 1 |
| 14 | Highly sensitive indirect photometric detection of cations by capillary electrophoresis with the cationic dye chrysoidine显示文摘 | C Johns M Macka P R Haddad | 2003 | J Chromatogr A2003，997，： | 1 |
| 15 | Adaptive median filters:new algorithms and results显示文摘 | HWANG H HADDAD R A | 1995 | IEEE Trans Image Processing1995，4，： | 1 |
| 16 | Stercoral perforation of thesigmoid colon显示文摘 | Haddad R Bursle G Piper B | 2005 | ANZ J Surg2005，75，4： | 1 |
| 17 | Microstructural and mechanical properties of friction stir welded Cu- 30Zn brass alloy at various feed speeds: Influence of stir bands 显示文摘 | SARVGHAD MOGHADDAM M PARVIZI R HADDAD?SABZEV AR M DA VOODI A | 2011 | Material Design2011，32，： | 1 |
| 18 | Adaptive median filters:new algorithm a- nd results显示文摘 | Hwang H Haddad R | 1995 | IEEE Transactions on Image Processing1995，，4： | 1 |
| 19 | Adaptive median filters:new algorithms and resuhs 显示文摘 | Hwang H Haddad R A | 1995 | IEEE Transactions on hnage Processing1995，4，4： | 1 |
| 20 | Detection of Thyroid Autoimmunity Markers inEuthyroid Women With Polycystic Ovary Syndrome: A Case-ControlStudy From Syria显示文摘 | Al-Saab R Haddad S | 2014 | Int J Endocrinol Metab2014，12，3： | 1 |
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