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| 1 | Cardiac implications of thrombotic thrombocytopenic purpura显示文摘Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular thrombosis.Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac involvement would also benefit from routine cardiology follow up during remission. | Szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai | 2018 | World Journal of Cardiology2018，10，12： | 2 |
| 2 | Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc 显示文摘 | Fernandez EL Gustafson AL Anderson M | 2003 | Reproduct Dev Toxicol2003，76，1： | 1 |
| 3 | Flow cytometreic S-phase fraction in soft tissue Sarcoma:prognostic importance analysed in 160 patients显示文摘 | Ferno M Akerman M | 1997 | Br J Cancer1997，75，1： | 1 |
| 4 | Secular trends in self re- ported seaual activity and satisfaction in Swedish 70 year olds:Cross sectional survey of four populations 1971-2001显示文摘 | Beckman N Waern M Gustafson D | 2008 | BMJ2008，337，： | 1 |
| 5 | Cytokine response in cerebrospinal fluid after birth asphyxia显示文摘 | Savman K Blennow M Gustafson K Tarkowski E Hagberg H | 1998 | Pediatr Res1998，43，6： | 1 |
| 6 | The macrolactins, a novel class of antiviral and eytotoxic macrolides from a deep-sea marine bacterium显示文摘 | Gustafson K Roman M Fenical W | 1989 | J Am Chem Soc1989，111，： | 1 |
| 7 | Vasa genes:Emerging roles in the germline and in multipotent cells显示文摘 | GUSTAFSON E A WESSEL G M | 2010 | Bio Essays2010，32，7： | 1 |
| 8 | The macrolactins, a novel class of antiviral and cytotoxic macro-lides from a deep sea marine bacterium显示文摘 | Gustafson K Roman M Fenical W | 1989 | J AmChemSoc1989，111，： | 1 |
| 9 | Tea tree oil causes K+ leakage and inhibits respiration in Escherichia coli显示文摘 | Cox S D Gustafson J E Mann C M | 1998 | Lett Appl Microbiol1998，26，： | 1 |
| 10 | Flexible tight-emitting diodes made from soluble conducting polymer显示文摘 | Gustafson G Cao Y Treaty G M | 1992 | Nature1992，357，： | 1 |
| 11 | Health benefits and practical aspects of high-flber diets 显示文摘 | Anderson J W Smith B M Gustafson N J | 1994 | The American Journal of Clinical Nutrition1994，59，5： | 1 |
| 12 | Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body mass index显示文摘 | Jedel E Waern M Gustafson D | 2010 | Hum Reprod2010，25，2： | 1 |
| 13 | A new method of describing lattice stabilities显示文摘 | ANDERSSON J O GUILLERMET A F GUSTAFSON P HILLERT M JANSSON B SUNDMAN B AGREN J | 1987 | Calphad1987，11，1： | 1 |
| 14 | Development and commercial use of Bollgard cotton in the USA-early promises versus today's reality显示文摘 | PERLAK F J Oppenhuizen M Gustafson K | 2001 | Plant J2001，27，： | 1 |
| 15 | Cholesterol and Alzheimer's disease-is there a relation 显示文摘 | Sjogren M Mielke M Gustafson D | 2006 | Mech Ageing Dev2006，127，2： | 1 |
| 16 | microRNA-direct- ed phasing during trans-acting siRNA biogenesis in plants 显示文摘 | Allen E Xie Z Gustafson A M | 2005 | Cell2005，121，2： | 1 |
| 17 | The pharmacodynamics and pharmaokinetics of the oral direct thrombin inhibitor xemelagatran and its active metabolite melagatran:min i-review显示文摘 | Gustafson D Elg M | 2003 | Thromb Res2003，109，1： | 1 |
| 18 | HIV inhibitory cembrane derivatives from a Philippines connection of the soft coral Lobophytum species显示文摘 | Rashid M A Gustafson K R Boyd M R | 2000 | Journal of Nature Products2000，63，： | 1 |
| 19 | Regulation of two rat mas-related genes in a model of neuropathic pain 显示文摘 | Gustafson E L Maguire M Campanella M | 2005 | Brain Res Mol Brain Res2005，142，： | 1 |
| 20 | An Empirical Model for Pollen-Mediated Gene Flow in Wheat显示文摘 | Horak M J Rempel C B | 2005 | Crop Science2005，45，4： | 1 |
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