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277篇 您的检索式:作者名="Gupta G C"
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1Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches.Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey 2018World Journal of Clinical Oncology2018,9,8:2
2The relationship between cancerre- lated fatigue and patient satiaction with quality of life in can - cer显示文摘Gupta D Lis C G Grutssh J F 2007J Pain Symptom Manage2007,34,1:1
3Thermal-Mechanical Modeling of the Rolling-Plus-Sliding with Frictional Heating of a Locomotive Wheel 显示文摘Gupta V Hahn G T Bostias P C et aI 1995Transactions of ASME1995,117,8:1
4The Interplay Between Ex- ploration and Exploitation 显示文摘Gupta A Smith K G Shalley C E 2006Academy of Management Journal2006,49,4:1
5Three-to six-year follow-up of stand-alone BAK cages implanted by a single surgeon 显示文摘Button G Gupta M Barrett C Cammack P Benson D 2005Sline J2005,5,:1
6Mediators of vascular remodelling co-opted for sequential steps in lung metastasis 显示文摘Gupta G P Nguyen D X Chiang A C 2007Nature2007,446,7137:1
7The interplay between exploration and exploitation显示文摘Gupta A K Smit K G Shalley C E 2006Academy of Management Journal2006,49,4:1
8PSO andANN _ based Fault Classification for ProtectiveRelaying 显示文摘Upenda J Gupta C P Singh G K 2010IET Generation Transmission andDistribution2010,4,10:1
9The interplay between exploration and exploitation 显示文摘Gupta A K Smith G K Shalley C E 200649(4) : 693 - 7062006,49,4:1
10The interplay between exploration and exploitation显示文摘GUPTA A K SMITH K G SHALLEY C E 2006Academy of Management Journal2006,49,4:1
11Hypolipidemie effect of Ginkgo biloba extract in hyperehlesterolemic rats 显示文摘Gupta U C Jain G C 2006Asian Journal of Experimental Science2006,20,1:1
12The relationship between can- cer-related fatigue and patient satisfaction with quality of life in cancer 显示文摘Gupta D Lis C G Grulsch J F 2007J Pain symptom Manage2007,34,1:1
13The Initial Succession:A Contingency Model of Founder Tenure显示文摘RUBENSON G C GUPTA A K 1996Entrepreneurship Theory and Practice1996,21,1:1
14Covalent grafting of polydimethylsiloxane over surface-modified alumina nanoparticles显示文摘Gupta S Ramamurthy P C Madras G 2011Ind Eng Chem Res2011,50,11:1
15Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventrlcular containment显示文摘Sabbah H N Sharer V G Gupta R C 2003Circ Res2003,93,11:1
16The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M 2010Science2010,330,6010:1
17The interplay between exploration and exploitation显示文摘Gupta A K Smith K G Shalley C E 2006Academy of Management Jour- nal2006,49,:1
18Prediction of the viscosity of clarified fruit juice using artificial neural network:a combined effect of concentration and temperature显示文摘Rai P Majumdar G C Das Gupta S 2005Journal of Food Engineering2005,68,4:1
19The Interplay Between Exploration and Exploitation 显示文摘Gupta A K Smith K G Shalley C E 2006Academy of Management Journal2006,49,4:1
20The interplay between exploration and exploitation 显示文摘Gupta A K Smith K G Shalley C E 2006Academy of Management Journal2006,49,4:1
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