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| 1 | Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity显示文摘瞄准:在导致 PC-2 房间 apoptosis 并且提高它的放射敏感度在胰腺的癌症房间线 PC-2 和 siRNA 的角色在 survivin 的表示上调查小介入 RNA (siRNA ) 的禁止的效果。方法:对 survivin 的 siRNA 原生质标志表示向量被构造并且 transfected 进有 Lipofectamine 2000 的 PC-2 房间。下面 survivin 表示的规定被半量的 RT-PCR 和免疫检测组织化学的 SP 方法和在导致 PC-2 房间 apoptosis 并且提高它的放射敏感度的 siRNA 的角色被流动血细胞计数检测。结果:顺序特定的 siRNA 高效地并且明确地下面调整在 mRNA 和蛋白质的 survivin 的表示铺平。表示抑制比率在半量的 RT-PCR 检测的 mRNA 水平是 81.25% , 74.24% 由免疫在蛋白质水平检测了组织化学的方法。在 transfection 以后的 48 个小时, apoptosis 被 siRNA 在 7.03% 房间导致,在 14.58% ,由 siRNA 的房间与放射结合了。结论:对 survivin 的 siRNA 原生质标志表示向量能高效地并且明确地在 PC-2 房间禁止 survivin 的表示。禁止 survivin 的表示能导致 PC-2 房间的 apoptosis 并且显著地提高它的放射敏感度。对 survivin 的 RNAi 具有在胰腺的癌症的基因治疗的潜在的价值。 | Hai-Tao Guan Xing-Huan Xue Zhi-Jun Dai Xi-Jing Wang Ang Li Zhao-Yin Qin | 2006 | World Journal of Gastroenterology2006，12，18： | 40 |
| 2 | KNOCKDOWN OF SURVIVIN EXPRESSION BY SMALL INTERFERING RNA SUPPRESSES PROLIFERATION OF TWO HUMAN CANCER CELL LINES显示文摘客观:对 survivin 构造小介入 RNA (siRNA ) 的表示向量并且在 survivin 表示和人的胰腺的癌症房间线 PC-2 和乳癌房间线 MCF-7 的增长上观察它的效果。方法:对 survivin 和 transfected 构造了 siRNA 的表示向量它进用 lipofectamine 的 PC-2 和 MCF-7 房间 2000。survivin 的表示被 semi-quantitive RT-PCR 和免疫组织化学检测,并且它 PC-2 和 MCF-7 房间的增长上的效果被 MTT 试金检测。结果:顺序特定的 siRNA 的介绍能高效地在二根癌症房间线在 mRNA 和蛋白质层次压制 survivin 表示。在 PC-2 房间,表示抑制率在 mRNA 水平是 81.25% , 74.24% 在蛋白质铺平。在 MCF-7 房间,表示抑制率在 mRNA 水平是 64.91% , 79.72% 在蛋白质铺平。PC-2 和 MCF-7 房间的增长也被压制,并且在房间以后的 24 和 48 个小时被重新播种 PC-2 房间的增长抑制率是 28.00% 和 33.38% ,并且 MCF-7 房间的分别地是 31.58% 和 33.02% 。结论:对 survivin 的 siRNA 的表示向量能高效地并且明确地在 PC-2 和 MCF-7 房间堵住 survivin 表示。在 survivin 的规定下面,表示能压制 PC-2 和 MCF-7 房间的增长。Survivin RNAi 可以在人的癌症的基因治疗有潜在的价值。 | Hai-tao Guan Xing-huan Xue Xi-jing Wang Ang Li Zhao-yin Qin | 2006 | Chinese Medical Sciences Journal2006，21，2： | 6 |
| 3 | Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study显示文摘 | Lee Guan Lim Sandeep Lakhtakia Tiing Leong Ang Charles K. F. Vu Frederick Dy Vui Heng Chong Christopher J. L. Khor Wee Chian Lim Bhavesh Kishor Doshi Shyam Varadarajulu Kenjiro Yasuda Jennie Y. Y. Wong Yiong Huak Chan Min En Nga Khek Yu Ho | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 4 | A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions显示文摘Polyetheretherketone(PEEK)is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical properties.However,the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants,especially under pathological conditions of osteoporosis.Herein,a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially.A degradable hybrid coating consisting of poly(lactide-co-glycolide)and alendronate(ALN)loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4(IL-4)is grafted onto the outer surface of the hybrid coating with the aid of N_(2) plasma immersion ion implantation and subsequent immersion in IL-4 solution.Dominant release of IL-4 together with ALN and Ca^(2+) during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone regeneration.Afterwards,slow and sustained delivery of ALN and Ca^(2+) in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously,consequently ameliorating bone-implant osseointegration even under osteoporotic conditions.By taking into account the different phases in bone repair,this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients. | Yanyan Zheng Ang Gao Jiaxiang Bai Qing Liao Yuzheng Wu Wei Zhang Min Guan Liping Tong Dechun Geng Xin Zhao Paul K.Chu Huaiyu Wang | 2022 | Bioactive Materials2022，7，8： | 2 |
| 5 | A clinical study of motor imagery based brain-computer interface for upper limb robotic rehabilitation显示文摘 | Ang KK Guan C Chua KS | 2009 | Conf Proc IEEE Eng Med Biol Soc2009，，： | 1 |
| 6 | Optimizing the channel selection and classification accuracy in EEG-based BCI 显示文摘 | ARVANEH M GUAN Cuntai ANG K K | 2011 | IEEE Trans Biomed Eng2011，58，6： | 1 |
| 7 | High - resolution melting facilitates mutation screening of rpsL gene associated with streptomycin resistance in Mycobacterium tuberculosis 显示文摘 | ang F Shen H Guan M | 2011 | Microbiol Res2011，166，2： | 1 |
| 8 | A large clinical study on the ability of stroke patients to use an EEG-based mo- tor imagery brain-computer interface显示文摘 | Ang KK Guan C Chua Ks | 2011 | Clin EEG Neu- rosei2011，42，4： | 1 |
| 9 | Optimizing the channel selection and classification accuracy in EEG-based BCI 显示文摘 | ARVANEH M GUAN C ANG K K | 2011 | IEEE Trans Biomed Eng2011，58，6： | 1 |
| 10 | A clinical evaluation of non-inva-sive motor imagery-based brain-computer inter&ce in stroke 显示文摘 | Ang KK Guan C Chua KS | 2008 | ConfProc IEEE Eng Med Biol Soc2008，2008，41： | 1 |
| 11 | Mutual infor- mation-based optimization of sparse spatio-spectral filters in brain-computer interface 显示文摘 | ARVANEH M GUAN C0 ANG K K | 2014 | Neural Computing and Applica- tions2014，25，34： | 1 |
| 12 | Optimizing the channel selection and classification accuracy in EEG- based BCI 显示文摘 | ARVANEH M GUAN C ANG K K | 2011 | IEEE Transactions on Biomedical Engi- neering2011，58，6： | 1 |
| 13 | Performance analysis of macprotocol for LEO satellite networks 显示文摘 | GUAN M X W ANG R C | | InternationalJournal on Communications Network and System Sciences 2 00 90，2，8： | 1 |
| 14 | An Open Laboratory Automatic Management System Based on RFID显示文摘 | Lu Ang Fan Ying Guan Zong qi | 2010 | IE EE Volume:3 Issue:292010，，： | 1 |
| 15 | Clinical study of neurorehabilitation in stroke using EEG-based motor imagery brain-computer interface with robotic feedback显示文摘 | Ang KK Guan C Chua KS | | 0，，： | 1 |
| 16 | Robust unit commitment with wind power and pumped storage hydro显示文摘 | J]ANG Rui-wei WANG Jian-hui GUAN Yong-pei | 2012 | IEEE Trans on Power Systems2012，27，2： | 1 |
| 17 | Detection of motor imagery of swallow EEG signals based on the dual-tree complex wavelet transform and adaptive model selection显示文摘 | Huijuan Yang Cuntai Guan Karen Sui Geok Chua See San Chok Chuan Chu Wang Phua Kok Soon Christina Ka Yin Tang Kai Keng Ang | 2014 | Journal of Neural Engineering2014，，3： | 1 |
| 18 | A Clinical study of neurorehabilitation in stroke using EEG-based motor imagery brain-computer interface with robotic feedback 显示文摘 | Ang KK Guan C Chua KS | 2010 | Conf Proc IEEE Eng Med Biol Soc2010，2010，： | 1 |
| 19 | Effect of Meridional Characteristic Angle on Aerodynamic Performance of Ram-Rotor显示文摘A kind of meridional concept which has a shape of contraction-expansion(Con-Exp)was applied to the ram-rotor in the paper,and detailed numerical simulation to understand the impact of meridional shape and geometric characteristic angle on the aerodynamic behavior of ram-rotors has been undertaken.Compared to baseline,there was a positive effect in intensifying shock train and suppressing low momentum fluid in Con-Exp scheme,and the pressure ratio and efficiency of Con-Exp scheme increased by 2.075%and 3.160%,respectively.When the contracting angle was increasing,supersonic flow at and after throat region accelerated remarkably,and the static pressure rise was decreased gradually.The terminating shock train was transformed to terminating shock,and the efficiency of ram-rotor was unfavorable to improve due to low throttle extent.As expanding angle rose,the terminating shock moved forward and turned to shock train gradually.The pressure rise capacity and throttling ability of ram-rotor were raised.More low momentum fluid was accumulated near the middle and upper flow-path,yielding greater flow loss at large expanding angle. | HAN Ji'ang GUAN Jian ZHONG Jingjun CHEN Luting | 2020 | Journal of Thermal Science2020，29，3： | 1 |
| 20 | 甲状腺相关性眼病伴眼外肌肌腱受累1例(英文)显示文摘目的:报告1例甲状腺相关性眼病的非典型CT扫描表现。方法:一位64岁的中国女性出现复视3mo,无视力模糊。14a前她曾患甲状腺功能亢进症伴多结节甲状腺肿并行甲状腺切除术。眼科检查发现双眼下斜视并向上注视受限。左眼red desaturation并Ⅰ级相对性瞳孔传入障碍。T3,T4和促甲状腺激素(thyroid stimulating hormone,TSH)正常。TSH受体、抗体水平高,与Graves'病一致。磁共振成像(magnetic resonance imaging,MRI)显示双下直肌弥漫性增大,肌腱受累。结果:给予几周期静脉注射甲基强的松龙继之以口服强的松后视力无提高,反之继续下降。行左眼眼眶减压术,术后其左眼视力有所改善。结论:有肌腱受累的眼外肌增大不能排除甲状腺相关性眼眶病(thyroid assciated orbitopathy,TAO)的可能。 | Ng Guan Fook Dinesh Kumar Ang Ee Ling Liza-Sharmini AT | 2012 | 国际眼科杂志2012，12，3： | 1 |
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