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| 1 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 2 | Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma显示文摘AIM: To investigate the expression deficiency of key molecular markers in the homologous recombination pathway. METHODS: Expression loss of breast cancer type 1 susceptibility protein (BRCA1), ataxia telangiectasia mutated (ATM), ATM-Rad3-related (ATR), mediator of DNA damage checkpoint protein 1 (MDC1) and meiotic recombination 11 (Mre11) were correlated with their clinicopathological parameters in gastric cancer (GC). One hundred and twenty treatment-naive GC samples were formalin-fixed and paraffin-embedded into tissue blocks. Two representative cores from each block were extracted and constructed into tissue microarrays. Expression levels of BRCA1, ATM, ATR, MDC1 and Mre11 were determined using immunohistochemical analysis, and correlated with clinical parameters, including age, gender, Lauren subtype, tumor grades, clinical stage and overall survival.RESULTS: Expression loss of BRCA1, ATM, ATR, MDC1, and Mre11 was found in 21.4%, 20.2%, 21.0%, 11.1% and 4.6%, respectively, of interpretable cases. BRCA1 loss was significantly associated with patients of diffused subtype (intestinal vs diffused, 8.2% vs 31.7%, P = 0.001), higher tumor grade (Ⅰ/Ⅱ vs Ⅲ, 10.7% vs 20.5;Ⅰ/Ⅱ vs Ⅳ, 10.7% vs 54.5%, P = 0.047) and advanced clinical stage (Ⅰ/Ⅱ vs Ⅲ, 12.9% vs 16.9%;Ⅰ /Ⅱ vs Ⅳ, 12.9% vs 45.5%, P = 0.006). MDC1 loss was significantly associated with patients of diffused subtype (intestinal vs diffused, 0% vs 19.7%, P = 0.001) and higher tumor grade (Ⅰ/Ⅱ vs Ⅲ, 0% vs 12%;Ⅰ/Ⅱ vs Ⅳ, 0% vs 30.8%, P = 0.012). In addition, the survival time of the patients with expression loss of BRCA1 was significantly shorter than those with positive expression of BRCA1 (2-year survival rate, 32.4% vs 62.8%, P = 0.015). No correlations were found between clinicopathological parameters and expression loss of ATM, ATR and Mre11. CONCLUSION: Our results support the hypothesis that homologous recombination deficiency plays an important role in the progression of gastric carcinoma. Loss of expression of BRCA1 and MDC1 may serve as predictive factors in tumor development or progression in GC patients. | Zi-Zhen Zhang Yuan Jie Charles Liu Xiao-Lu Yin Ping Zhan Yi Gu Xing-Zhi Ni | 2013 | World Journal of Gastroenterology2013，19，12： | 11 |
| 3 | Surgical complications after different therapeutic approaches for locally advanced rectal cancer显示文摘BACKGROUND Preoperative radiochemotherapy is widely used in locally advanced rectal cancer.It can improve local control of rectal cancer. However, some researchers believe it increases the incidence of surgical complications. They doubt its safety. Patients with locally advanced rectal cancer receive three different treatments in our hospital, including long-course radiochemotherapy, short-course radiotherapy,and surgery directly. We can compare their differences in postoperative complications.AIM To investigate surgical complications caused by different preoperative radiotherapy regimens.METHODS We retrospectively analyzed 1197 patients admitted between 2008 and 2010 with locally advanced rectal cancer. Three hundred and forty-six patients were treated with preoperative long-course radiochemotherapy(25 × 2 Gy) followed by total mesorectal excision(TME) 6–8 wk later, and 259 patients received short-course radiotherapy(10 × 3 Gy) and subsequently TME 7–10 d later. The remaining 592 patients underwent TME alone without neoadjuvant therapy. According to Clavien–Dindo classification, surgical complications were evaluated for up to 30 d after discharge from hospital.RESULTS There were no deaths in 30 d in all groups after treatment. The majorcomplications were anastomotic leakage and perineal wound complications. The results suggested that both long-course [odds ratio(OR) = 3.624, 95% confidence interval(CI): 1.689–7.775, P = 0.001] and short-course(OR = 5.150, 95%CI:1.828–14.515, P = 0.002) radiotherapy were associated with anastomotic leakage.Temporary ileostomy was a protective factor for anastomotic leakage(OR =6.211, 95%CI: 2.525–15.385, P < 0.001). The severity of anastomotic leakage did not increase in patients following preoperative radiotherapy(P = 0.411).Compared with TME alone, short-course radiotherapy was associated with an increase in perineal wound complications(OR = 5.565, 95%CI: 2.203–14.057, P <0.001), but long-course radiotherapy seemed safe regarding this complication(OR= 1.692, 95%CI: 0.651–4.394, P = 0.280). Although the severity of perineal wound complications increased in patients following short-course radiotherapy(P <0.001), additional intervention was not necessary.CONCLUSION Radiotherapy increased the incidence but not severity of anastomotic leakage.Short-course radiotherapy was also accompanied with perineal wound complications, but intervention appeared unnecessary to ameliorate the complications. | Tian-Cheng Zhan Da-Kui Zhang Jin Gu Ming Li | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 9 |
| 4 | Non-destructive detection of pigments in oil painting by using terahertz tomography显示文摘Dear Editors,Terahertz technology has been applied in many fields[1–3].The protection and restoration of historical relics and cultural heritage,which is a new application area of terahertz technology,have been attracting much attention recently[4,5]because of its social significance and market prospects.The most important premise is to obtain information of the cultural relics without damaging them again.Therefore the appropriate non-destructively testing methods are | ZHANG ZhenWei WANG KeJia LEI Yong ZHANG ZhuoYong ZHANG ZhenWei WANG KeJia LEI Yong ZHANG ZhuoYong ZHAO YuanMeng LI ChenYu GU An SHI NingChang ZHAO Kun ZHAN HongLei ZHANG CunLin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 8 |
| 5 | Optical forces of focused femtosecond laserpulses on nonlinear optical Rayleigh particles显示文摘The principle of optical trapping is conventionally based on the interaction of optical fields with linear-induced polarizations. However, the optical force originating from the nonlinear polarization becomes significant when nonlinear optical nanoparticles are trapped by femtosecond laser pulses. Herein we develop the time-averaged optical forces on a nonlinear optical nanoparticle using high-repetition-rate femtosecond laser pulses, based on the linear and nonlinear polarization effects. We investigate the dependence of the optical forces on the magnitudes and signs of the refractive nonlinearities. It is found that the self-focusing effect enhances the trapping ability, whereas the self-defocusing effect leads to the splitting of the potential well at the focal plane and destabilizes the optical trap. Our results show good agreement with the reported experimental observations and provide theoretical support for capturing nonlinear optical particles. | LIPING GONG BING GU GUANGHAO RUI YIPING CUI ZHUQING ZHU QIWEN ZHAN | 2018 | Photonics Research2018，6，2： | 8 |
| 6 | Acute exacerbation of chronic obstructive pulmonary disease treated by extracorporeal carbon dioxide removal显示文摘To the Editor: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients often required mechanical ventilation support. But ventilator-related side effects are still inevitable, leading to treatment failure. The extracorporeal carbon dioxide removal (ECCO2R) technique drains blood to artificial membrane lungs, performing oxygenation and removing carbon dioxide without mechanical ventilation. ECCO2R has been widely used outside China, but there is no official report of its use in China. Recently, we treated two AECOPD patients using ECCO2R. | Min Li Si-Chao Gu Jin-Gen Xia Qing-Yuan Zhan | 2019 | Chinese Medical Journal2019，，20： | 6 |
| 7 | Self-starting passively mode-locked all fiber laser based on carbon nanotubes with radially polarized emission显示文摘We demonstrate an all fiber passively mode-locked laser emitting a radially polarized beam by using a few-mode fiber Bragg grating to achieve mode selection and spectrum filtering. An offset splicing of single-mode fiber with four-mode fiber is utilized as a mode coupler in the laser cavity. Carbon nanotubes are introduced into the laser cavity as the saturable absorber to achieve self-start mode locking. The laser operates at 1547.5 nm with a narrow spectrum width of 0.3 nm at 30 d B. The emitted mode-locked pulses have a duration of 22.73 ps and repetition of10.61 MHz. A radially polarized beam has been obtained with high mode purity by adjusting the polarization in the laser cavity. | Yong Zhou Jian Lin Xiaoqiang Zhang Lixin Xu Chun Gu Biao Sun Anting Wang Qiwen Zhan | 2016 | Photonics Research2016，4，6： | 6 |
| 8 | The expression of oxidative stress genes related to myocardial ischemia reperfusion injury in patients with ST-elevation myocardial infarction显示文摘BACKGROUND:We aimed to investigate the gene expression of myocardial ischemia/reperfusion injury(MIRI)in patients with acute ST-elevation myocardial infarction(STEMI)using stress and toxicity pathway gene chip technology and try to determine the underlying mechanism.METHODS:The mononuclear cells were separated by ficoll centrifugation,and plasma total antioxidant capacity(T-AOC)was determined by the ferric reducing ability of plasma(FRAP)assay.The expression of toxic oxidative stress genes was determined and verified by oligo gene chip and quantitative real-time polymerase chain reaction(qRT-PCR).Additionally,gene ontology(GO)enrichment analysis was performed on DAVID website to analyze the potential mechanism further.RESULTS:The total numbers of white blood cells(WBC)and neutrophils(N)in the peripheral blood of STEMI patients(the AMI group)were significantly higher than those in the control group(WBC:11.67±4.85×10^(9)/L vs.6.41±0.72×10^(9)/L,P<0.05;N:9.27±4.75×10^(9)/L vs.3.89±0.81×10^(9)/L,P<0.05),and WBCs were significantly associated with creatine kinase-myocardial band(CK-MB)on the first day(Y=8.945+0.018X,P<0.05).In addition,the T-AOC was significantly lower in the AMI group comparing to the control group(12.80±1.79 U/mL vs.20.48±2.55 U/mL,P<0.05).According to the gene analysis,eight up-regulated differentially expressed genes(DEGs)included GADD45A,PRDX2,HSPD1,DNAJB1,DNAJB2,RAD50,TNFSF6,and TRADD.Four down-regulated DEGs contained CCNG1,CAT,CYP1A1,and ATM.TNFSF6 and CYP1A1 were detected by polymerase chain reaction(PCR)to verify the expression at different time points,and the results showed that TNFSF6 was up-regulated and CYP1A1 was down-regulated as the total expression.GO and kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis suggested that the oxidative stress genes mediate MIRI via various ways such as unfolded protein response(UPR)and apoptosis.CONCLUSIONS:WBCs,especially neutrophils,were the critical cells that mediating reperfusion injury.MIRI was regulated by various genes,including oxidative metabolic stress,heat shock,DNA damage and repair,and apoptosis-related genes.The underlying pathway may be associated with UPR and apoptosis,which may be the novel therapeutic target. | Qian-lin Gu Peng Jiang Hui-fen Ruan Hao Tang Yang-bing Liang Zhong-fu Ma Hong Zhan | 2022 | World Journal of Emergency Medicine2022，13，2： | 5 |
| 9 | NUMERICAL STUDY ON THE MIXING OF UNSORTED SEDIMENT PARTICLES DISCHARGED INTO A CROSS-FLOW BY MULTIPHASE PARTICLE-IN-CELL (MP-PIC) METHOD显示文摘The mixing characteristics of dredged sediments of variable size discharged into cross-flow are studied by an Eulerian-Lagrangian method. A three-dimensional (3D) numerical model has been developed by using the modified k-ε parameterization for the turbulence in fluid phase/water and a Lagrangian method for the solid phase/sediments. In the model the wake turbulence induced by sediments has been included as additional source and sink terms in the k-ε model; and the trajectories of the sediments are tracked by the Lagrangian method in which the sediment drift velocities in cross-flow are computed by a multiphase particle-in-cell (MP-PIC) method and the diffusion process is approximated by a random walk model. The hydrodynamic behavior of dumped sediment cloud is governed by the total buoyancy on the cloud, the drag force on each particle and velocity of cross-flow. The cross-flow destroys more or less the double vortices occurred in stagnant ambience and dominates the longitudinal movement of sediment cloud. The computed results suggest satisfactory agreement by comparison with the experimental results of laboratory. | Jie GU Chiwai LI Hong YANG Yong ZHAN | 2007 | International Journal of Sediment Research2007，22，2： | 5 |
| 10 | Pneumonia Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus: Vancomycin or Linezolid?显示文摘 | Ye Tian Xu Huang Li-Juan Wu Li Yi Min Li Si-Chao Gu Dong-Jie Guo Qing-Yuan Zhan | 2018 | Chinese Medical Journal2018，，16： | 5 |
| 11 | A high-quality genome assembly of Morinda officinalis,a famous native southern herb in the Lingnan region of southern China显示文摘Morinda officinalis is a well-known medicinal and edible plant that is widely cultivated in the Lingnan region of southern China.Its dried roots(called bajitian in traditional Chinese medicine)are broadly used to treat various diseases,such as impotence and rheumatism.Here,we report a high-quality chromosome-scale genome assembly of M.officinalis using Nanopore single-molecule sequencing and Hi-C technology.The assembled genome size was 484.85Mb with a scaffold N50 of 40.97 Mb,and 90.77%of the assembled sequences were anchored on eleven pseudochromosomes.The genome includes 27,698 protein-coding genes,and most of the assemblies are repetitive sequences.Genome evolution analysis revealed that M.officinalis underwent core eudicotγgenome triplication events but no recent whole-genome duplication(WGD).Likewise,comparative genomic analysis showed no large-scale structural variation after species divergence between M.officinalis and Coffea canephora.Moreover,gene family analysis indicated that gene families associated with plant–pathogen interactions and sugar metabolism were significantly expanded in M.officinalis.Furthermore,we identified many candidate genes involved in the biosynthesis of major active components such as anthraquinones,iridoids and polysaccharides.In addition,we also found that the DHQS,GGPPS,TPS-Clin,TPS04,sacA,and UGDH gene families—which include the critical genes for active component biosynthesis—were expanded in M.officinalis.This study provides a valuable resource for understanding M.officinalis genome evolution and active component biosynthesis.This work will facilitate genetic improvement and molecular breeding of this commercially important plant. | Jihua Wang Shiqiang Xu Yu Mei Shike Cai Yan Gu Minyang Sun Zhan Liang Yong Xiao Muqing Zhang Shaohai Yang | 2021 | Horticulture Research2021，8，1： | 4 |
| 12 | Analysis of moisture diffusivity of larch timber during convective drying condition by using Crank's method and Dincer's method显示文摘采用两种改进的多孔固体材料水分扩散偏微分方程分析求解方法,即Dincer方法与Crank方法,分析并计算落叶松干燥过程的水分扩散系数(D)与水分传递系数(k)。使用扩散型微分方程对落叶松干燥过程进行数学模拟,木材试件被理想化为无限大平板状材料,假定木材内部水分的扩散过程是一维的。实验测定了不同干燥介质条件下木材干燥动力曲线。基于取得的实验数据,通过Dincer方法计算了木材水分扩散系数(D)与水分传递系数(k);使用传统的Crank方法分析计算了木材动态水分扩散系数(D)。研究表明,使用Dincer方法计算的木材水分扩散系数(D)均大于相应实验条件下Crank方法计算数值,接近1个数量级。这种结论应该是由于两种分析求解方法间的差异以及水分扩散与热量传递数学求解间的差异。因此相关的水分扩散微分方程的分析求解方法有待改进。随干燥介质温度的升高,木材水分扩散系数(D)与水分传递系数k均显著增大,可以采用Arrhenius方程与木材结合水传递理论来分析解释实验条件下的扩散系数(D)与干燥介质温度(T)间的变化趋势。图2表3参6。 | ZHAN Jian-feng GU Ji-you CAI Ying-chun | 2007 | Journal of Forestry Research2007，18，3： | 4 |
| 13 | Optically induced rotation of Rayleigh particles by arbitrary photonic spin显示文摘Optical trapping techniques hold great interest for their advantages that enable direct handling of nanoparticles. In this work, we study the optical trapping effects of a diffraction-limited focal field possessing an arbitrary photonic spin and propose a convenient method to manipulate the movement behavior of the trapped nanoparticles. In order to achieve controllable spin axis orientation and ellipticity of the tightly focused beam in three dimensions, an efficient method to analytically calculate and experimentally generate complex optical fields at the pupil plane of a high numerical aperture lens is developed. By numerically calculating the optical forces and torques of Rayleigh particles with spherical/ellipsoidal shape, we demonstrate that the interactions between the tunable photonic spin and nanoparticles lead to not only 3D trapping but also precise control of the nanoparticles' movements in terms of stable orientation, rotational orientation, and rotation frequency. This versatile trapping method may open up new avenues for optical trapping and their applications in various scientific fields. | GUANGHAO RUI YING LI SICHAO ZHOU YUSONG WANG BING GU YIPING CUI QIWEN ZHAN | 2019 | Photonics Research2019，7，1： | 4 |
| 14 | Enhanced alumina film adhesion of Hf/Y-doped iron-aluminum alloys during high-temperature oxidation:a new observation显示文摘The cyclic oxidation behavior of Hf/Y-doped B2 FeAl intermetallics at 1373 K was investigated.For an undoped FeAl alloy,premature spallation of the alumina film occurs due to the formation of numerous voids at the film/alloy interface and apparent shrinkage in the film.In contrast to this,doping with either Hf or Y significantly improves the interfacial adhesion between the alumina film and the alloy substrate,particularly with Hf-doping.Microstructural observation in combination with Anger electron spectroscopic analysis suggests that in addition to prohibiting interfacial void formation and alleviating film shrinkage,the addition of Hf in the FeAl alloy could consolidate the film/alloy interface by directly participating in chemical bonding across the interface as a Hf ion.This causes the spallation of alumina film from the equiaxed grains/columnar grains interface rather than the bottom of the film. | Dong-Qing Li Li-Xian Zhou Jun Zhan Jing-Chao Wang Jian Gu Jia-Jun Si | 2019 | Rare Metals2019，38，9： | 3 |
| 15 | Infliximab is effective in the treatment of ulcerative colitis with dermatomyositis:A case report显示文摘BACKGROUND Joint,skin,oral cavity,and eye lesions are the most common extraintestinal manifestations of ulcerative colitis that can occur before or after its onset.The cases of ulcerative colitis with dermatomyositis(DM)are rare.In this study,we report a rare case of ulcerative colitis with DM that was effectively treated with infliximab.CASE SUMMARY The patient was a 57-year-old female with a 2-year history of DM.The patient was admitted to hospital with abdominal pain,diarrhea,and blood in stool lasting for more than 2 mo.Colonoscopy revealed multiple erosions and ulcers in the entire colon and rectum.Pathological sections showed chronic inflammatory cell infiltration,especially neutrophil infiltration,in the colonic mucosa;therefore,the patient was diagnosed with ulcerative colitis.Preparations of 5-aminosalicylic acid was added to her treatment based on the original treatment for DM,but its effect was unsatisfactory.The patient’s discomfort was relieved after infliximab treatment.CONCLUSION Infliximab can improve DM in the treatment of ulcerative colitis.Specialists need to raise awareness about patients with inflammatory bowel disease who have rare extraintestinal manifestations. | Bin-Bin Huang Li-Chun Han Geng-Feng Liu Xiao-Dan Lv Guang-Li Gu Shi-Quan Li Lan Chen Hui-Qin Wang Ling-Ling Zhan Xiao-Ping Lv | 2020 | World Journal of Gastroenterology2020，26，46： | 3 |
| 16 | COMPARING PERFORMANCE OF CROP SPECIES MIXTURES AND PURE STANDS显示文摘Intercropping is the planned cultivation of species mixtures on agricultural land.Intercropping has many attributes that make it attractive for developing a more sustainable agriculture,such as high yield,high resource use efficiency,lower input requirements,natural suppression of pests,pathogens and weeds,and building a soil with more organic carbon and nitrogen.Information is needed which species combinations perform best under different circumstances and which management is suitable to bring out the best from intercropping in a given production situation.The literature is replete with case studies on intercropping from across the globe,but evidence synthesis is needed to make this information accessible.Meta-analysis requires a careful choice of metric that is appropriate for answering the question at hand,and which lends itself for a robust meta-analysis.This paper reviews some metrics that may be used in the quantitative synthesis of literature data on intercropping. | Wopke VAN DER WERF Lizhen ZHANG Chunjie LI Ping CHEN Chen FENG Zhan XU Chaochun ZHANG Chunfeng GU Lammert BASTIAANS David MAKOWSKI TjeerdJan STOMPH | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 2 |
| 17 | Expressions of p53 and inducible nitric oxid synthase in congenital choledochal cysts显示文摘BACKGROUND: Choledochal cyst, an isolated defect un- restricted to the bile duct, is more appropriately regarded as the sentinel feature of a constellation of anomalies affect- ing the pancreatobiliary system. This study was to assess the relationship between the expression of inducible nitric oxide synthase (iNOS) and the p53 gene as well as the pathoge- nesis of choledochal cysts. METHODS: iNOS and p53 were detected by immunohisto- chemistry staining in 26 patients with congenital choledo- chal cysts. Histopathologically, hyperplasia of the mucosa of the cysts and the amylase level in the bile were also inve- stigated. RESULTS: Patients with a high level of amylase in the bile had higher expression of iNOS than those with a low level of amylase. p53 protein was expressed neither in fusiform type nor in cystic type. The incidence of mucosal hyperpla- sia was significantly higher in the fusiform type than that in the cystic type. CONCLUSIONS: Higher expression of iNOS may partici- pate in hyperplasia and carcinogenesis of the mucosa of choledochal cysts. The regurgitation of pancreatic juice in- to the biliary system might induce mucosal hyperplasia of the biliary tract and inflammatory reaction. In preventing regurgitation-caused hyperplasia and malignancy of the bi- liary tract, early surgery is important for children with con- genital choledochal cysts. | Jiang-Hua Zhan, Xiao-Li Hu, Chun-Juan Dai, Jun Niu and Ji-Qing Gu Tianjin, China Department of Pediatric Surgery, Tianjin Children’s Hospital, Tianjin 300000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 2 |
| 18 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 19 | 血浆D-二聚体水平与转移性胃癌患者生存期的关系(英文)显示文摘Objective:The principal purpose of this study was to determine the relationship between level of plasma D-dimer and survival time in metastatic gastric cancer patients.Methods:We retrospectively collected the data of plasma D-dimer in metastatic gastric cancer patients admitted in our Department (Department of Oncology,The Affiliated Changzheng Hospital,The Second Military Medical University,Shanghai,China) from October 2006 to October 2008 and analyzed the relationship between level of plasma D-dimer and survival time along with other clinicopathologic parameters.Results:A total of 82 patients were studied in our research,52 were males and 30 females,and the mean age was 57 years.The 48 cases had a normal plasma D-dimer level (<300μg/L) and 34 had a high plasma D-dimer level (≥300μg/L).In the normal and high plasma D-dimer level groups,the mean survival times were 10.9 (95% CI:9.8-12.2) months and 6.8(95% CI:4.4-7.6) months respectively,and the difference was statistically significant.Conclusion:Metastatic gastric cancer patients with high plasma D-dimer level had significantly shorter survival time than those with normal plasma D-dimer level.Level of plasma D-dimer can be referred as a potential predictor in metastatic gastric cancer patients. | Xiaodong Jiao Jianxin Qian Guanzhen Yu Rui Li Zhan Wang Jin Wang Xiaoqiang Gu Jiejun Wang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 2 |
| 20 | Understanding the role of tungsten on Pt/CeO_(2)for vinyl chloride catalytic combustion显示文摘Spherical CeO_(2)synthesized by the hydrothermal process was used as support to prepare Pt/WO_(3)/CeO_(2),and the effects of tungsten(W)contents on activity,stability and polychlorinated by-products were investigated to understand the role of W for vinyl chloride(VC)catalytic oxidation.The introduction of12 wt%W to Pt/CeO_(2)(P12 WC)exhibits the highest catalytic activity with 90%conversion of VC at 250℃,meanwhile the stability improves and the polychlorinated by-products in the tail gas significantly decrease due to the removal of dissociated Cl species in the formation of HCl.The beneficial effects of W on Pt/CeO_(2)are closely related to the chemical state of Pt,redox and surface acid sites distribution.The doped W not only makes Pt disperse evenly on the support with the high valence,but also weakens the interaction between Pt and CeO_(2)by the formation of Pt-O-W and Pt-O-W-O-Ce species,which facilitates oxygen mobility.In addition,the modification of W species also significantly increases the surface acidity amount and changes the distribution of acid sites. | Qifeng Zhang Zhengbo Zhou Tian Fang Han Gu Yanglong Guo Wangcheng Zhan Yun Guo Li Wang | 2022 | Journal of Rare Earths2022，40，9： | 2 |
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