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| 1 | Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?显示文摘Our understanding of the microbial involvement in inflammatory bowel disease(IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or 'dysbiosis' is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity(including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years. | Georgina L Hold Megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya | 2014 | World Journal of Gastroenterology2014，20，5： | 21 |
| 2 | TiO_2在Al_2O_3表面上分散状态的AEM研究显示文摘本文运用AEM方法考察了制备技术对TiO_2在Al_2O_3表面分散状态的影响.发现嫁接法可使TiO_2非常均匀地分散在Al_2O_3表面上,浸渍法也能得到较为均匀的TiO_2分布,而沉淀法所得到的TiO_2分散度较差.TiO_3只聚集在Al_20_3表面上的局部区域。 | 魏昭彬 辛勤 Sham E.L. Grange P. Delwon B. | 1990 | 物理化学学报1990，6，4： | 18 |
| 3 | Laparoendoscopic single-site radical prostatectomy: technique and initial outcomes显示文摘 | ZHU Gang ZHANG Ya-qun Philippe Grange Kilian Walsh JIN Bin ZHANG Yao-guang CHEN Xin WANG xuan WEI Dong WAN Ben WANG Jian-ye | 2012 | Chinese Medical Journal2012，，21： | 2 |
| 4 | Infection complications in febrile chimeric antigen receptor(CAR)-T recipients during the peri-CAR-T cell treatment period examined using metagenomic next-generation sequencing(mNGS)显示文摘Dear Editor,Chimeric antigen receptor-engineered(CAR)-T cell therapy has achieved unprecedented efficacy on refractory/relapsed B-cell malignancies[1].Yet,CAR-T recipients are highly susceptible to infection due to the immunodeficiency caused by B-cell aplasia and the pretreatment with chemotherapy.However,due to the systematic use of empirical broad-spectrum antibiotics and immunosuppressors to control cytokine release syndrome(CRS)reaction,microbiological diagnosis of infection has remained challenging in CAR-T recipients. | Jiali Nie Li Yang Liang Huang Lili Gao Ken He Young Jehane Michael Le Grange Xingcheng Yang Jia Wei Min Xiao Jianfeng Zhou | 2022 | Cancer Communications2022，42，5： | 2 |
| 5 | Hydrotreating catalysts, an old story with new challenges显示文摘 | GRANGE P VANHAEREN X | 1997 | Catal Today1997，36，4： | 1 |
| 6 | The promise of immuno-therapy for tuberculosis显示文摘 | Stanford JL Grange JM | 1994 | Resirat Med1994，88，1： | 1 |
| 7 | Identification of an intestinal neutral glycosphingolipid as a phenotype-specific receptor for the K88ad fimbrial adhesin of Escherichia coli显示文摘 | Grange P A Erickson A K Levery S B | 1999 | Infect Immu1999，67，1： | 1 |
| 8 | Time Series Analysis, Co-integration, and Applications显示文摘 | CLIVE Grange | 2014 | American Economic Review2014，94，3： | 1 |
| 9 | Hydrodesulfurization catalysts显示文摘 | Grange P | 1980 | Catal Rev Sci Eng1980，22，： | 1 |
| 10 | Myco bacterium vaccae immunotherapy显示文摘 | Pozniak A Stanford JL Grange JM | 1991 | Lancet1991，338，6： | 1 |
| 11 | Transferrin associated with the porcine intestinal mucosa is a receptor specific for K88ab fimbfiae of Escherichia coli显示文摘 | Grange P A Mouricout M A | 1996 | Infect Immu1996，64，： | 1 |
| 12 | Differences in MMPs and TIMP-1 expression between intervertebral disc and disc herniation 显示文摘 | Baillet A Grange L Trocme C | 2013 | Joint Bone Spine2013，80，3： | 1 |
| 13 | The adsorption of nitric oxide on supported Co-Mo hydrodesulfurization catalysts: A review显示文摘 | PORTELA L GRANGE P DELMON B | 1995 | Catal Rev: Sci Eng1995，37，4： | 1 |
| 14 | A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximah显示文摘 | Marotte H Pallot-Prades B Grange L | 2007 | Arthritis Res Ther2007，9，3： | 1 |
| 15 | A ease of multiple myeloma with multilobulated and convoluted plasma cell muclei 显示文摘 | Grange M J Fantin B Carbon C | 1992 | Nouv Rev Fr Hematol1992，34，： | 1 |
| 16 | Expression of mucin-type glycorprotein K88 receptors strongly correlates with piglet Suscep-tibility to K88+enterotoxigenic Escherichia coli,but adhesion of this bacterium to brush borders dose not显示文摘 | Francis DH Grange PA Zeman DH | 1998 | Infection and Immunity1998，66，9： | 1 |
| 17 | Keshin - Beck disease and drinking water in Central Tibet 显示文摘 | La Grange M Mathieu F Begaux F | 2001 | International Orthopaedics2001，25，3： | 1 |
| 18 | Inverse association between melanoma and previous vaccinations against tuberculosis and smallpox:results of the FEBIM study显示文摘 | Pfahlberg A Kolmel KF Grange JM | 2002 | J Invest Dermatol2002，119，3： | 1 |
| 19 | Pharmacokinetic profiles of twotablet formulations of piroxicam显示文摘 | Rasetti - Escargueil C Grange V | 2005 | Inti J Pharmy2005，295，： | 1 |
| 20 | Biodistribution of mesenchymal stem cell-derived extracellular vesiclesin a model of acute kidney injury monitored by optical imaging显示文摘 | Cristina Grange Marta Tapparo Stefania Bruno Devasis Chatterjee Peter Quesenberry Ciro Tetta Giovanni Camussi | 2014 | International Journal of Molecular Medicine2014，，5： | 1 |
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