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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Enhanced capacities and selectivities for cholesterol in aqueous media by molecular imprinting role of novel cross-linkers 显示文摘 | Gore M A Karmalkar R N GKulkarni M | 2004 | Journal of Chromatography B2004，804，： | 1 |
| 3 | Reagentless pH - based biosensing using a fluorescently - labelled dextran coentrapped with a hydrolytic enzyme in solgel derived nanocomposite films显示文摘 | GULCEV M D GORING L G GILLIAN R M | 2002 | Anal Chim Acta2002，457，1： | 1 |
| 4 | Study on ultrasound assisted precipitation of CL-20 and its effect on morphology and sensitivity显示文摘 | Sivabalan R Gore G M Nair U R | 2007 | Journal of Hazardous Materials2007，139，： | 1 |
| 5 | The flatness of lignosulfonate macromolecules as demonstrated by elec- tron microscopy 显示文摘 | Goring D A I Vuong R Gancet C | 1979 | Journal of Applied Polymer Sci- ence1979，24，4： | 1 |
| 6 | Comorbidity and Karnofksy performance score are independent prognostic factors in stageIII nonsmall cell lung cancer:an institutional analysis of patients treated on four RTOG studies显示文摘 | Firat S Byhardt R W Gore E | 2002 | Radiation Therapy Oncology Group2002，54，2： | 1 |
| 7 | The effect of humidity on the curing of 3-glycidoxypropyltrimethoxy silane (GPS) 显示文摘 | Underhill P R Goring G DuQuesnay D L | 2000 | International Journal of Adhesion Adhesive2000，20，3： | 1 |
| 8 | Endurance training altars antioxidant enzyme gene expression in rat skeletal muscle显示文摘 | Gore M Fiebig R Hollander J | 1998 | Can J Physiol Pharmacol 1998 Dec1998，76，12： | 1 |
| 9 | Spatio-temporal Data Types: An Approach to Modeling and Querying Moving Objects in Databases显示文摘 | Erwig M GOring R H Schneider M et el | 1999 | GeoInformatica1999，3，3： | 1 |
| 10 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 11 | Superoxide disrnutase gene expression is activated by a single bout of exercise in rat skeletal muscle显示文摘 | Hollander J Fiebig R Gore M | 2001 | P flugers Arch 2001 Jun2001，442，3： | 1 |
| 12 | Effect of particle size on modulating turbulent显示文摘 | GORE R A CROWE C T | 1989 | Int J of Multiphase Flow1989，15，2： | 1 |
| 13 | Study onultrasound assisted precipitation of CL-20 andits effect on morphlogy and sensitivity显示文摘 | Sivabalan R Gore G M Nair U R | 2007 | Journalof Hazardous Materials2007，139，2： | 1 |
| 14 | Evaluation of ferrocene derivatives as bum rate modifiers in AP/HTPB based composite propellants 显示文摘 | Gore G M Tipare K R Bhatewara R G | 1999 | Defence Science Journal1999，49，2： | 1 |
| 15 | The flatness of lignosulfonate macromolecules as demonstrated by electron mieroscopy显示文摘 | GORING D A L VUONG R GANCET C | 1979 | Journal of Applied Polymer Science1979，24，4： | 1 |
| 16 | Superoxide dismutase gene expression in skeletal muscle: fiber-specific adaptation to endurance training显示文摘 | Hollander J Fiebig R Gore M | 1999 | Am J Physiol 1999 Sep1999，277，32： | 1 |
| 17 | Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement显示文摘 | Evanthia Diamanti-Kandarakis Jean-Pierre Bourguignon Linda C. Giudice Russ Hauser Gail S. Prins Ana M. Soto R Thomas Zoeller Andrea C. Gore | 2009 | Endocrine Reviews2009，，4： | 1 |
| 18 | An overview of MIMO communications-a key to gigabit wireless显示文摘 | Paulraj A J Gore D A Nabar R U | 2004 | Proceedings of the IEEE2004，92，2： | 1 |
| 19 | Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1,a putative component of the exocyst complex显示文摘 | Samuel M A Chong Y T Haasen K E Aldea-Brydges M G Stone S L Goring D R | | 0，，09： | 1 |
| 20 | Risk for intracranial hemorrhage after tissue plasminogen activator treatment for acute myocardial infarction: participants in the National Registry of Myocardial Infarction 2显示文摘 | Gurwitz JH Gore JM Goldberg R J | 1998 | Ann Intern Med1998，129，： | 1 |
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