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| 1 | Multi-detector computed tomography in the diagnosis and management of acute aortic syndromes显示文摘Acute aortic syndrome(AAS) is a spectrum of conditions, which may ultimately progress to potentially life-threatening aortic rupture. This syndrome encompasses aortic dissection(AD), intramural haematoma, penetrating atherosclerotic ulcer and unstable thoracic aortic aneurysms. Multi-detector CT(MDCT) is crucial for the diagnosis of AAS, especially in the emergency setting due to its speed, accuracy and ready availability. This review attends to the value of appropriate imaging protocols in obtaining good quality images that can permit a confident diagnosis of AAS. AD is the most commonly encountered AAS and also the one with maximum potential to cause catastrophic outcome if not diagnosed and managed promptly. Hence, this review briefly addresses certain relevant clinical perspectives on this condition. Differentiating the false from the true lumen in AD is often essential; a spectrum of CT findings, e.g., 'beak sign', aortic 'cobwebs' that allows such differentiation have been described with explicit illustrations. The value of non enhanced CT scans, especially useful in the diagnosis of an intramural hematoma has also been illustrated. Overlap in the clinical and imaging features of the various conditions presenting as AAS is not unusual. However, on most instances MDCT enables the rightdiagnosis. On select occasions MRI or trans-esophageal echocardiography may be required as a problem solving tool. | James Thomas Patrick Decourcy Hallinan Gopinathan Anil | 2014 | World Journal of Radiology2014，6，6： | 11 |
| 2 | Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases显示文摘Mitochondria are one of the major sites for the genera-tion of reactive oxygen species(ROS) as an undesirable side product of oxidative energy metabolism. Damaged mitochondria can augment the generation of ROS. Dys-function of mitochondria increase the risk for a large number of human diseases, including cardiovascular diseases(CVDs). Heart failure(HF) following ischemic heart disease, infantile cardiomyopathy and cardiac hypertrophy associated with left ventricular dilations are some of the CVDs in which the role of mitochon-drial oxidative stress has been reported. Advances in mitochondrial research during the last decade focused on the preservation of its function in the myocardium, which is vital for the cellular energy production. Expe-rimental and clinical trials have been conducted using mitochondria-targeted molecules like: MnSOD mimetics, such as EUK-8, EUK-134 and MitoSOD; choline esters of glutathione and N-acetyl-L-cysteine; triphenylphospho-nium ligated vitamin E, lipoic acid, plastoquinone andmitoCoQ10; and Szeto-Schiller(SS)- peptides(SS-02 and SS-31). Although many results are inconclusive, some of the findings, especially on CoQ10, are worthwhile. This review summarizes the role of mitochondria-tar-geted delivery of agents and their consequences in the control of HF. | Thekkuttuparambil Ananthanarayanan Ajith Thankamani Gopinathan Jayakumar | 2014 | World Journal of Cardiology2014，6，10： | 7 |
| 3 | Management of neglected cervical spine dislocation: a study of six cases显示文摘没有神经病学的赤字的六忽视的颈的脊骨脱臼的一个案例系列,它是管理了 operatively.MethodsThe 学习的 ObjectiveTo 报告从 2010 年 8 月被进行到 2011 年 12 月,案例从医药教育和研究的研究生研究所的门诊部被选择,印度。病人在 30 ~ 50 年的年龄组。所有病人经由前面、以后的 approaches.ResultsDuring 被操作立即的手术后的时期,五(83.33%) 病人们有正常神经病学的地位。有 C 5-C6 subluxation 的(16.67%)病人在在更低的手足的 2/5 和在在 C 6 level.ConclusionThere 下面的上面的手足的 3/5 的水平和马达功率是的 C 6下面与感觉损失开发了神经病学的赤字在对颈的脊骨的忽视的分散注意力的屈曲损害的颅骨拖拉的角色都没为更多推迟比 3 个星期。以后由前面的途径列在后面节省许多时间。如果两条途径将在一样的坐被做,其次地对乐器学没有需要。但是如果上演过程是 planed,以后的稳定被推荐,,有在神经病学的地位的恶化的风险。 | Vijay Goni Nirmal Raj Gopinathan Vibhu Krishnan Rajesh Kumar Avinash Kumar | 2013 | Chinese Journal of Traumatology2013，16，4： | 6 |
| 4 | Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications显示文摘Recently,the metal ion cross-linked hydrogels have gained enormous interest because of its excellent properties like self-healing,fast recovery,biocompatibility and high mechanical properties combined with multi-stimuli responsiveness.In this review article,we have summarized the recent trends in the development of metal ion cross-linked hydrogels for tissue engineering and biomedical applications.A number of metal ions and their contribution in the synthesis of various cross-linked hydrogels are discussed with respect to their crosslinking mechanisms,compositions,physio-chemical and biological properties.A special emphasis has been given to ferric(Fe^(3+))ion cross-linked hydrogels and their different combinations owing to their numerous researches reported in the recent past with exceptional properties.The application of these metal ion based hydrogels in biomedical applications including tissue engineering,sensing,wound healing,drug delivery and as tissue adhesive and tissue sealants are reviewed with specific examples.Importantly,the application of these metal ion cross-linked hydrogels as inks in 3 D printing is explained in a separate section.Finally,the possible toxic effects of the different metal ions and their effects have been scrutinized.Future directions and comprehensive applications of the hydrogels are highlighted. | Gopinathan Janarthanan Insup Noh | 2021 | Journal of Materials Science & Technology2021，，4： | 5 |
| 5 | Molt and reproduction enhancement together with hemolymph ecdysteroid elevation under eyestalk ablation in the female fiddler crab,Uca triangularis(Brachyura:Decapoda)显示文摘We present the results of eyestalk extirpation experiments performed on the fiddler crab, Uca triangularis at seasons of molting and reproduction, with a view to have a better understanding of the regulatory mechanisms of these two highly energy-demanding processes. Bilateral eyestalk ablation resulted in precocious acceleration of both molting and reproduction, irrespective of the season at which each experiment was conducted. The rate of accelerated ovarian growth, however, was maximum if the eyestalk ablation was conducted during August–January, the breeding season in the wild, or in February–May(molting-reproductive season), wherein a section of the wild population would be engaged in molting and another section in breeding. The highest degree of precocious molt acceleration, on the other hand, was obtained during June–July when the population was primarily engaged in molting, but with no reproductive activity. The precocious oocyte maturation(due to de-eyestalking) was minimal in June–July. Significantly, the eyestalk ablation also resulted in a dramatic increase in the hemolymph ecdysteroid titer, revealing that a high ecdysteroid titer would have no restraining influence on vitellogenesis. No spawning was, however, observed among de-eyestalked females, even though their final oocyte size surpassed the size of the normal mature oocytes, implying that spawning is not exclusively under the control of eyestalk hormones. A comparative study performed on the vitelline components of the experimentals and the controls revealed that the precociously incorporated yolk under eyestalk ablation was biochemically impoverished. These results indicate that throughout the annual cycle, both the somatic and the reproductive growth of U. triangularis are under the influence of inhibitory principles from the eyestalks. It is also revealing that mere deprival of the inhibitory principles does not culminate into successful vitellogenesis. Arguably, the inhibitory influence from the eyestalks could be a prerequisite for normal healthy maturation of the oocytes and spawning. | SUPRIYA Nagathinkal T SUDHA Kappalli KRISHNAKUMAR Velayudhannair ANILKUMAR Gopinathan | 2017 | Chinese Journal of Oceanology and Limnology2017，35，3： | 3 |
| 6 | Elbow dislocation with ipsilateral diaphyseal forearm bone fracture: A rare injury report with literature review显示文摘 | Vijay Goni Prateek Behera Umesh Kumar Meena Nirmal raj Gopinathan Narendranadh Akkina R.H.H. Arjun | 2015 | Chinese Journal of Traumatology2015，18，2： | 2 |
| 7 | Proximal tibial and fibular physeal fracture causing popliteal artery injury and peroneal nerve injury: A case report and review of literature显示文摘 | Uday Guled Nirmal Raj Gopinathan Vijay G. Goni Arjun Rhh Rakesh John Prateek Behera | 2015 | Chinese Journal of Traumatology2015，18，4： | 2 |
| 8 | : The epidemiological features and laboratory resuhs of fungal keratitis: a 10-year re- view at a referral eye care center in South India 显示文摘 | Gopinathan U Garg P Fernandes M | 2002 | Cornea2002，21，： | 1 |
| 9 | Segmented Block Copolymers of Natural Rubber and 1,3-Butanediol-Toluene Diisocyanate Oligomers显示文摘 | Paul C J Gopinathan N M R Neelakantan N R | 1998 | Polymer1998，39，： | 1 |
| 10 | Enzymatic, clinical and histologic evaluation of corneal tissues in experimen- tal fungal keratitis in rabbits 显示文摘 | Gopinathan U Ramakrishna T Willcox M | 2001 | Exp Eye Res2001，72，4： | 1 |
| 11 | Identification of an enhencer-like element in the polyhedrin gene upstream region of Bombyx mori nueleopolyhedrovirus 显示文摘 | ACHARYA A GOPINATHAN K P | 2001 | Journal of General Virology2001，82，： | 1 |
| 12 | Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nucleopolyhedrovirus 显示文摘 | Acharya A Gopinathan K P | 2002 | J Gen Virol2002，83，8： | 1 |
| 13 | The preparation of quick-cooking dehydrated vegetables by high temperature shots time pneumatic drying显示文摘 | JAYARAMAN K S GOPINATHAN V K PITCHAMUTHU P | 1982 | Journal of Food Technology1982，17，： | 1 |
| 14 | Keratomycosis: Clinical and microbiologic experience with dermatiaceous fungi 显示文摘 | GARG P GOPINATHAN U CHOIJDHARY K | 2000 | Ophthalmology2000，107，3： | 1 |
| 15 | Segmented Blockcopolymers of Natural Rubber and Bisphenol Atoluene Diisocyanate Oligomers 显示文摘 | Paul C J Gopinathan N M R Koshypeter | 1999 | J of Applied Polymer Science1999，74，3： | 1 |
| 16 | 显示文摘 | Andrew M Beale Gopinathan S | 2003 | Nuclear Instruments and Methods in Physics Research B2003，199，： | 1 |
| 17 | Evaluation of corneal scraping smear examination methods in the diagnosis of bacterial and fungal keratitis: a survey of eight years of laborato- ry experience显示文摘 | Sharma S Kunimoto DY Gopinathan U | 2002 | Cornea2002，21，： | 1 |
| 18 | Kirauras disease:imaging patterns on computed toraography显示文摘 | Gopinathan A Tan T Y | 2009 | Clin Radiol2009，64，10： | 1 |
| 19 | Novel ruthenium(Ⅱ) Schiff base complexes显示文摘 | Gopinathan S Deshpande S S Gopinatha C | 1989 | Synth React Inorg MetOrg Chem1989，19，4： | 1 |
| 20 | Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nueleopolyhedrovirus 显示文摘 | Acharya A Gopinathan K P | 2002 | Journal of General Virology2002，83，8： | 1 |
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