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| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 3 | Capacitated arc routing problems显示文摘 | Golden B L Wong R T | 1981 | Networks1981，11，： | 1 |
| 4 | Video display terminals and miscarriage 显示文摘 | McChesney R Golden A | 2000 | J Am Med Womens Assoc2000，55，2： | 1 |
| 5 | Analysis of a large-scale vehiclerouting problem with an inventory component显示文摘 | GOLDEN B ASSAD A DAHL R | 1984 | Large Scale Systems in Information and Decision Technologies1984，7，23： | 1 |
| 6 | Simplified processing for high spectral efficiency wireless communication employing multi-element arrays显示文摘 | Foschini G J Golden G D Valenzuela R A | 1999 | IEEE Journal on Selected Areas in Communications1999，17，11： | 1 |
| 7 | Impressions of Retail Stores:A Content Analysis of Consumer Images显示文摘 | ZIMMER M R GOLDEN L L | | 0，，03： | 1 |
| 8 | Stochastic vehicle routing: A comprehensive approach显示文摘 | Stewart W R Golden B L | 1983 | European Journal of Operational Research1983，14，3： | 1 |
| 9 | Capacitated arc routing problems 显示文摘 | Golden B Wong R | 1981 | Networks1981，11，： | 1 |
| 10 | When will boards influence strategy? Inclinationxpower=strategic change 显示文摘 | Golden B R Zajac E J | 2001 | Strategic ManagementJournal2001，22，12： | 1 |
| 11 | Evaluating the efficiency of SBDCSwith data envelopment analysis: A longitudinal approach显示文摘 | Lang J R Golden P | 1989 | Journal of Small Business Management1989，，27： | 1 |
| 12 | Beauty is in the eye of the beholder: The impact of organizational identification, identity, and image on the cooperative behaviors of physicians显示文摘 | Dukerich J M Golden B R and Shortell S M | 2002 | Administrative Science Quarterly2002，47，3： | 1 |
| 13 | When will boards influence strategy? Inclination ×strategic change显示文摘 | Golden B R Zajac E J | 2001 | Strategic Management Journal2001，22，： | 1 |
| 14 | Thermochemistry of Some Six-Membered Cyclic and Polycyclic Compounds Debated to Coal显示文摘 | Shaw R Golden D M Benson S W | 1977 | JPhys Chem1977，81，12： | 1 |
| 15 | Board composition from adolescence to maturity: a multi-theoretic view显示文摘 | Lynall M Golden B R Hillman A | 2003 | Academy of Management Review2003，28，： | 1 |
| 16 | Simplified processing for high spectral efficiency wireless communication employing multi-element arrays显示文摘 | GOLDEN G VALENZUELA R | 1999 | IEEE journal on Selected Areas in Communication1999，17，11： | 1 |
| 17 | A fracture mechardcs life predietloa methodology applied to dovetail fretting 显示文摘 | Golden P J Calcaterra J R | 2006 | Tribology International2006，39，： | 1 |
| 18 | Beauty is in the Eye of the Beholder: The Impact of Organizational Identification, Identity, and Image on the Cooperative Behaviors of Physicians显示文摘 | Dukerich J M Golden B R Shortell S M | 2002 | Administrative Science Quarterly2002，47，3： | 1 |
| 19 | Competing inter- actions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuro- epithelium 显示文摘 | Sathyan P Golden H B Miranda R C | 2007 | J Neurosci2007，27，32： | 1 |
| 20 | Capacitated arc routing problems显示文摘 | Golden B L Wong R T | 1981 | Networks1981，，： | 1 |
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