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| 1 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 2 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 3 | Use of XMTM radio satellite signal as a source of opportunity for passive coherent location 显示文摘 | Gill L P Grenier D Chouinard J Y | 2011 | lET Proceeding on Radar Sonar and Navigation2011，5，5： | 1 |
| 4 | Movement quality and links to measures of fitness in firefighters显示文摘 | Me Gill S Frost D Andersen J | 2013 | Work2013，45，3： | 1 |
| 5 | Robotic intracorporeal ortho- topic ileal neobladder: replicating open surgical principles 显示文摘 | Goh AC Gill IS Lee D J | 2012 | Eur Urol2012，62，5： | 1 |
| 6 | The empirics of agglomeration economies 显示文摘 | GILLES D HENDERSON J V STRANGE W C | 2015 | Handbook of Regional and Urban Economics2015，，5： | 1 |
| 7 | Enzymatic production of acetaldehyde from ethanol in rat brain tissue显示文摘 | GILL K MENEZ J F LUCAS D | 1992 | Alcohol Clin Exp Res1992，16，： | 1 |
| 8 | Coated microneedles for drug delivery to the eye 显示文摘 | JIANG J GILL H S GHATE D | 2007 | Invest Ophthalmol Vis Sci2007，48，9： | 1 |
| 9 | Forensic application of DNA finger- prints'显示文摘 | Gill P Jeffreys A J Werrett D J | 1985 | Nature1985，318，6046： | 1 |
| 10 | HER-2 involvement in osteo- sarcoma显示文摘 | Gill J Geller D Gorlick R | 2014 | Adv Exp Med Biol2014，804，： | 1 |
| 11 | Transumbilical single-port laparoscopic partial nephrectomy显示文摘 | Aron M Canes D Desai M M Haber G P Kaouk J H Gill I S | 2009 | BJU Int2009，103，： | 1 |
| 12 | 查看详情显示文摘 | Sarkar M D Gill N L Whitehead J B Crawford G P | | 0，，： | 1 |
| 13 | Coated microneedles for drug delivery to the eye显示文摘 | Jiang J Gill HS Ghate D | 2007 | Investigative ophthalmology & visual science2007，48，9： | 1 |
| 14 | Ductility of square- confined concrete columns 显示文摘 | Park R Priestley M J N Gill W D | 1982 | Journal of the Structural Division ASCE1982，108，4： | 1 |
| 15 | Ductility of square- confined concrete columns 显示文摘 | Park R Priestley M J N Gill W D | 1982 | Journal of the Structural Division ASCE1982，108，4： | 1 |
| 16 | Detection and Quantification of Biomolecular Interactions with Optical Biosensors显示文摘 | Yeung D Gill A Davies R J | 1995 | Trends Anal Chem1995，42，： | 1 |
| 17 | Training-specific muscle architecture adaptation after 5-wk training in athletes显示文摘 | Blazevich A J Gill N D Bronks R | 2003 | Med Sci Sports Exerc2003，35，12： | 1 |
| 18 | International Consensus Statement on testing and reporting of antineutrophil cytoplasmic antibodies(ANCA)显示文摘 | Savige J Gills D Benson E | | 0，，04： | 1 |
| 19 | Arthroscopic Reduction and Internal Fixation of Tibial Plateau Fractures in Skiing显示文摘 | Gill T J Moezzi D M Oates K M | 2001 | Clin Orthop2001，383，： | 1 |
| 20 | Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: a systematic review of survival, mortality, and mor- bidity显示文摘 | Gill R S Al-Adra D P Nagendran J | 2011 | J Surg Oncol2011，104，6： | 1 |
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