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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | The spatial distribution of major and trace elements of surface sediments in the northeastern Beibu Gulf of the South China Sea显示文摘A multi-index analysis including grain size, major and trace elements is performed on the surface sediments from the northeastern Beibu Gulf to trace the sources of the sediments and to understand the controlling factors for elements distribution. The mean grain size exhibits a wide variation ranging from 0.09Φ to 8.05Φ with an average value of 5.33Φ. The average contents of major elements descend in an order of c(SiO_2)>c(Al_2O_3)>c(Fe_2O_3)>c(CaO)>c(MgO)>c(K_2O)>c(Na_2O)>c(TiO_2)>c(P_2O_5)>c(MnO), while those of trace elements exhibit a descending order of c(Sr)>c(Rb)>c(V)>c(Zn)>c(Cr)>c(Pb)>c(Ni)>c(Cu)>c(As). On the basis of elementary distribution characteristics and statistical analyses, the study area is divided into the four zones: Zone I is located in the northeastern coastal area of the gulf, which receives large amount of fluvial materials from local rivers in Guangxi and Guangdong, China, and the Qiongzhou Strait; Zone Ⅱ is located in the center of the study area, where surface sediments exhibits a multiple source; Zone Ⅲ is located in the Qiongzhou Strait, where surface sediments are dominated by materials from the Zhujiang River and Hainan; Zone IV is located in the southwest of the study area, where surface sediments are mainly originated from the Red River and Hainan. The statistical analyses of sediment geochemical characteristics reveal that the grain size, which is mainly influenced by hydrodynamics and mineral composition of terrigenous materials, is the leading factor controlling the elementary distribution.Meanwhile, impacts from anthropogenic activities and marine biogenic process will also be taken into consideration. | Qian Ge George Z Xue Liming Ye Dong Xu Jianru Zhao Fengyou Chu | 2019 | Acta Oceanologica Sinica2019，38，3： | 5 |
| 3 | Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions显示文摘Point-of-care(POC) tests enable rapid results and are well established in medical practice.Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways.This review aims to identify current and newtechnologies for the POC diagnosis of gastrointestinal cancer.A structured search of the Embase and Medline databases was performed.Papers reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were included.Studies recovered were heterogeneous and therefore results are presented as a narrative review.Six diagnostic methods were identified(fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis).Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%.The others are at a range of development and clinical application.POC devices have a proven role in the diagnosis of gastrointestinal cancer.Barriers to their implementation exist and the transition from experimental to clinical medicine is currently slow.New technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival. | Jeremy R Huddy Melody Z Ni Sheraz R Markar George B Hanna | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 4 | Muscle wasting in rheumatoid arthritis:The role of oxidative stress显示文摘Rheumatoid arthritis(RA), the commonest inflammatory arthritis, is a debilitating disease leading to functional and social disability. In addition to the joints, RA affects several other tissues of the body including the muscle. RA patients have significantly less muscle mass compared to the general population. Several theories have been proposed to explain this. High grade inflammation, a central component in the pathophysiology of the disease, has long been proposed as the key driver of muscle wasting. More recent findings however, indicate that inflammation on its own cannot fully explain the high prevalence of muscle wasting in RA. Thus, thecontribution of other potential confounders, such as nutrition and physical activity, has also been studied. Results indicate that they play a significant role in muscle wasting in RA, but again neither of these factors seems to be able to fully explain the condition. Oxidative stress is one of the major mechanisms thought to contribute to the development and progression of RA but its potential contribution to muscle wasting in these patients has received limited attention. Oxidative stress has been shown to promote muscle wasting in healthy populations and people with several chronic conditions. Moreover, all of the aforementioned potential contributors to muscle wasting in RA(i.e., inflammation, nutrition, and physical activity) may promote pro- or antioxidative mechanisms. This review aims to highlight the importance of oxidative stress as a driving mechanism for muscle wasting in RA and discusses potential interventions that may promote muscle regeneration via reduction in oxidative stress. | Antonios Stavropoulos-Kalinoglou Charikleia Deli George D Kitas Athanasios Z Jamurtas | 2014 | World Journal of Rheumatology2014，4，3： | 2 |
| 5 | The postantibiotic effect: a review of in vitro and in vivo data显示文摘 | George G Z Daryl J H Godfrey K M | 1991 | Ann Pharma cother1991，25，： | 1 |
| 6 | Molecular mobility of super-cooled amorphous indomethacin,determined by dy-namic mechanical analysis显示文摘 | George Z | 1997 | Pharm Res1997，14，4： | 1 |
| 7 | Improving Diamond Coating on Ti6Al4VSubstrate Using a Diamond Like Carbon Interlayer:Raman Residual Stress Evaluation and AFM Analyses显示文摘 | Nibennanoune Z George D Antoni F | 2012 | Diamond&Related Materials2012，22，： | 1 |
| 8 | Protein kinase PKR and RNA adenosine deaminase ADAR1 : new roles for old players as modu|ators of the interferon response 显示文摘 | Pfaller CK Li Z George CX | 2011 | Curr Opin Immunol2011，23，5： | 1 |
| 9 | Alow resistance boron-doped carbon nanotube-polystyrene composite显示文摘 | Paul C P Watts Wen Kuang Hsu George Z Chen | 2001 | J Mater Chem2001，11，： | 1 |
| 10 | Service Mining on the Web显示文摘 | George Z B A | 2009 | the VLDB Jour- nal2009，2，1： | 1 |
| 11 | Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State显示文摘 | Wenjun Guo Zuzana Keckesova Joana Liu Donaher Tsukasa Shibue Verena Tischler Ferenc Reinhardt Shalev Itzkovitz Aurelia Noske Ursina Zürrer-H?rdi George Bell Wai Leong Tam Sendurai A. Mani Alexander van Oudenaarden Robert A. Weinberg | 2012 | Cell2012，，5： | 1 |
| 12 | Model study of the thermal storage system by FEHM code 显示文摘 | Norio Kasumi Y George Z | 2003 | Geothennics2003，32，4： | 1 |
| 13 | Serum transforming growth factor-β1 is related to the degree of immunoparesis in patients with multiple myeloma显示文摘 | Maria-Christina Kyrtsonis Constantina Repa George (XXXV) Z Dedoussis Athanasia Mouzaki Argyris Simeonidis Marina Stamatelou Alice Maniatis | 1998 | Medical Oncology1998，，2： | 1 |
| 14 | Room temperature ultraviolet laser emission from microstructured ZnO thin film显示文摘 | Yu P George K L | 1997 | Nonlinear Optics1997，18，24： | 1 |
| 15 | Automated residue analysis of tetracyclines and their metabolites in whole egg,egg white,egg yolk and hen's plasma utilizing a modified ASTED system显示文摘 | GEORG Z ERIKA M S MICHAEL | 2000 | Journal of Chromatography B:Biomedical Sciences and Applications2000，739，： | 1 |
| 16 | Direct electrochemical reduction of titanium dioxide to titanium in molten calcium chloride显示文摘 | George Z Chen Derek J Fray Tom W Farthing | 2000 | Nature2000，407，21： | 1 |
| 17 | Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well preserved neoplastic cells 显示文摘 | DAS D K SHEIKH Z A GEORGE S S | 2008 | Diagn Cytopathol2008，36，： | 1 |
| 18 | Controlled precipitation of nesquehonite(MgCO3·3H2O)by the reaction of MgCl2 with(NH4)2CO3显示文摘 | Wang Y Li Z B George P D | 2008 | Journal of Crystal Growth2008，310，6： | 1 |
| 19 | Pulsed cyclophosphamide,thalidomide and dexamethasone:An oral regimen for previously treated patients with multiple myeloma显示文摘 | Meletios AD George H Athanasios Z | 2004 | Hematology J2004，5，： | 1 |
| 20 | Problem-based learning in a nursing informaties curriculum显示文摘 | George D Brenda Z | 2010 | Nurse Educ Today2010，30，2： | 1 |
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