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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 3 | Kounis syndrome:a clinical entity penetrating from pediatrics to geriatrics显示文摘1 Introduction Kounis syndrome constitutes a coronary hypersensitivity disorder defined by the association of an anaphylactoid,anaphylactic,allergic or hypersensitivity reaction with an acute coronary syndrome,in a physiopathological context involving various interrelated and interacting inflammatory cells,such as mast-cells,eosinophils and platelets.[1,2]Similar entities to Kounis syndrome might involve cerebral and mesenteric arteries. | Mattia Giovannini Ioanna Koniari Francesca Mori Silvia Ricci Luciano De Simone Silvia Favilli Sandra Trapani Giuseppe Indolfi Nicholas George Kounis Elio Novembre | 2020 | Journal of Geriatric Cardiology2020，17，5： | 7 |
| 4 | Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms显示文摘 | George J.M. Webster Stephanie Reignat Mala K. Maini Simon A. Whalley Graham S. Ogg Abigail King David Brown Peter L. Amlot Roger Williams Diego Vergani Geoffrey M. Dusheiko Antonio Bertoletti | 2000 | Hepatology2000，，5： | 4 |
| 5 | Oil-bearing fluid inclusions from the Palaeoproterozoic:A review of biogeochemical results from time-capsules >2.0 Ga old显示文摘The observation of oil inclusions trapped prior to 2.0 Ga in Palaeoproterozoic rocks and the ability to obtain detailed molecular geochemical information from them provide a robust way for understanding the early biogeochemical evolution of the Earth. Oil-bearing fluid inclusions (FI) in ca. 2.45 Ga fluvial metaconglomerate of the Matinenda Formation at Elliot Lake, Canada were trapped in quartz and feldspar during diagenesis and early metamorphism of the host rock, probably before ca. 2.2 Ga. The 2.1 Ga FA Formation sandstone of the Franceville Basin in Gabon that hosts the Oklo natural fission reactors has also been discovered to contain abundant Palaeoproterozoic oil-bearing FIs. This oil occurs within H2O and CO2-dominated inclusions trapped in syntaxial quartz overgrowths and intragranular and transgranular microfractures in detrital quartz, and was most likely trapped 2.1-1.98 Ga. Molecular geochemical analyses of both FI oils reveal a wide range of compounds, including n-alkanes, isoprenoids, monomethylalkanes, aromatic hydrocarbons, and trace amounts of complex multi-ring biomarkers including terpanes, hopanes, methylhopanes, steranes and diasteranes. To ensure a reliable interpretation of oil inclusions, a comprehensive series of outside-rinse blanks and procedural system blanks was analysed by gas chromatography-mass spectrometry; quantitative amounts of the hydrocarbons in these blanks were compared to the FI extracts, so as to provide confidence limits on the experimental integrity of each compound class. Maturity ratios based on reliably detected compound classes show that the FI oils were generated in the oil window, with no evidence of extensive thermal cracking. The presence of biomarkers for cyanobacteria and eukaryotes derived from and trapped in rocks deposited prior to 2.0 Ga is consistent with early evolution of oxygenic photosynthesis and suggests that some aquatic settings had become sufficiently oxygenated for sterol biosynthesis by this time. The extraction of biomarker molecules from Palaeoproterozoic oil-bearing FIs thus establishes a new method, using low detection limits and system blank levels, to trace evolution through Earth's early history that avoids the potential contamination problems affecting shale-hosted hydrocarbons. | Simon C. GEORGE Adriana DUTKIEWICZ Herbert VOLK John RIDLEY David J. MOSSMAN Roger BUICK | 2009 | Science China Earth Sciences2009，52，1： | 3 |
| 6 | Does laser surface texturing really have a negative impact on the fatigue lifetime of mechanical components?显示文摘Laser surface texturing(LST)has been proven to improve the tribological performance of machine elements.The micro-scale patterns manufactured by LST may act as lubricant reservoirs,thus supplying oil when encountering insufficient lubrication.However,not many studies have investigated the use of LST in the boundary lubrication regime,likely due to concerns of higher contact stresses that can occur with the increasing surface roughness.This study aims to examine the influence of LST on the fatigue lifetime of thrust rolling bearings under boundary lubrication.A series of periodic patterns were produced on the thrust rolling bearings,using two geometrically different designs,namely cross and dimple patterns.Base oil ISO VG 100 mixed with 0.05 wt%P of zinc dialkyldithiophosphate(ZDDP)was supplied.The bearings with cross patterns reduce the wear loss by two orders of magnitude.The patterns not only retain lubricant in the textured pockets but also enhance the formation of an anti-wear tribofilm.The tribofilm generation may be improved by the higher contact stresses that occur when using the textured surface.Therefore,in contrast to the negative concerns,the ball bearings with cross patterns were instead found to increase the fatigue life by a factor of three. | Chia-Jui HSU Andreas STRATMANN Simon MEDINA Georg JACOBS Frank MÜCKLICH Carsten GACHOT | 2021 | Friction2021，9，6： | 3 |
| 7 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
| 8 | Portal Hypertension in Children: Expert Pediatric Opinion on the Report of the Baveno V Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension显示文摘 | Benjamin L. Shneider Jaime Bosch Roberto de Franchis Sukru H. Emre Roberto J. Groszmann Simon C. Ling Jonathan M. Lorenz Robert H. Squires Riccardo A. Superina Ann E. Thompson George V. Mazariegos | 2012 | Pediatric Transplantation2012，，5： | 2 |
| 9 | Field Cancerization in the Intestinal Epithelium of Patients With Crohn’s Ileocolitis显示文摘 | Susan Galandiuk Manuel Rodriguez–Justo Rosemary Jeffery Anna M. Nicholson Yong Cheng Dahmane Oukrif George Elia Simon J. Leedham Stuart A.C. McDonald Nicholas A. Wright Trevor A. Graham | 2012 | Gastroenterology2012，，4： | 2 |
| 10 | Dynamic cooperative advertising in a channel显示文摘 | Steffen J?rgensen Simon Pierre Sigué Georges Zaccour | 2000 | Journal of Retailing2000，，1： | 2 |
| 11 | Evaluating hyperspectral vegetation indices for estimating nitrogen concentration of winter wheat at different growth stages显示文摘 | Fei Li Yuxin Miao Simon D. Hennig Martin L. Gnyp Xinping Chen Liangliang Jia Georg Bareth | 2010 | Precision Agriculture2010，，4： | 2 |
| 12 | The CONSTANS gene of arabidopsis promotes flowering and encodes a protein showing similarities to zinc finger transcription factors显示文摘 | Joanna Putterill Frances Robson Karen Lee Rüdiger Simon George Coupland | 1995 | Cell1995，，6： | 2 |
| 13 | 植物鞣剂/MUF树脂鞣制时皮革的耐光性及鞣剂的抗老化性显示文摘制备了一种蜜胺含量相对较低的新型磺化蜜胺-脲-甲醛(MUF)缩聚树脂,此树脂与不同的天然植物鞣质复合鞣革,成革具有和铬鞣革一样良好的性能。提出了不同的鞣质/MUF树脂复合物鞣制的皮革,在长时间的紫外线辐射下,以革色的变化作为老化时间的函数,建立并阐明了此函数的预测模型和公式。此函数不仅与固态纯鞣质的抗老化能力有关,还与其在皮革内总体的抗老化能力有关。 | B George A Pizzi C Simon M C Triboulot 张业聪 付丽红 | 2007 | 中国皮革2007，36，15： | 2 |
| 14 | The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin显示文摘 | Simon R. Smukler Margot E. Arntfield Rozita Razavi George Bikopoulos Phillip Karpowicz Raewyn Seaberg Feihan Dai Simon Lee Rosemary Ahrens Paul E. Fraser Michael B. Wheeler Derek van der Kooy | 2011 | Cell Stem Cell2011，，3： | 2 |
| 15 | 柴北缘鱼卡地区中侏罗统石门沟组含煤层段沉积有机相分析显示文摘柴达木盆地北缘鱼卡地区中侏罗统石门沟组含煤段中发育有油页岩、煤、碳质泥岩和泥岩等富有机质细粒沉积。为了研究其沉积有机相的类型及煤和油页岩形成的控制因素,本文通过岩心观察、工业分析结合有机地球化学测试分析等方法将含煤段细粒沉积物划分为了类型A(三角洲平原沉积环境)、B(三角洲前缘-浅湖沉积环境)、C1(湖沼非油页岩亚相)及C2(湖沼油页岩亚相)四种类型,其中类型C1沉积物中发育煤,类型C2中发育油页岩,且煤较油页岩具有更高的含油率、水分、挥发分以及发热量值。有机质类型特征方面,沉积有机相类型A、B及C1沉积物有机质类型均为Ⅱ2-Ⅲ型、有机质来源均以陆源和混合来源两种有机质来源为主,而类型C2中主要为II2型,以混合有机质来源为主;类型A及C2其沉积物有机质均处于未成熟阶段,而类型B和C1中有机质均处于未成熟-低成熟阶段;有机质保存条件方面,类型A沉积物主要形成于缺氧的淡水环境,类型B主要形成于贫氧-缺氧的淡水-半咸水环境,类型C1形成于贫氧-缺氧的淡水-半咸水环境,而类型C2则主要形成于缺氧的淡水-半咸水环境。其中类型B较类型A,类型C2较类型C1,其沉积物均形成于更为还原且盐度更高的水体环境中。石门沟组含煤段是煤和油页岩的形成层位,稳定的沉积环境、丰富的湖泊有机质来源、良好的保存条件及较少的陆源碎屑的稀释共同促进了类型C2中油页岩的形成,而丰富的陆源植物供给及良好的保存条件则促进了类型C1中煤层的形成。 | 白悦悦 吕庆田 刘招君 Simon C GEORGE 孙平昌 孟庆涛 谢文泉 宋青磊 王君贤 徐川 | 2021 | 地球学报2021，42，4： | 2 |
| 16 | The Dependence of Benzo-15-Crown-5 Ether-Containing Oligo Paraphenylene Vinylene (CE-OPV) Emission Upon Complexation with Metal Ions in Solution显示文摘 | Gowri Ramachandran George Simon Yibing Cheng Trevor A. Smith Liming Dai | 2003 | Journal of Fluorescence2003，，5： | 1 |
| 17 | Study of the specificity of cross-povidone(PVPP) as binding agent in the quantification of polyphenolic compounds显示文摘 | Simone GV Cabral P George GO | 2008 | Braz Chem Soc2008，19，8： | 1 |
| 18 | Long-term quality of life in trauma patients following the full spectrum of tibial injury (fasciotomy, closed fracture, grade IIIB/IIIC open fracture and amputation)显示文摘 | Peter V. Giannoudis Paul J. Harwood George Kontakis Mohamad Allami David Macdonald Simon P. Kay Paul Kind | 2008 | Injury2008，，2： | 1 |
| 19 | On neighbor-selection strategy in hybrid peer-to-peer networks显示文摘 | Simon G M Koo Karthik Kannan C S George Lee | 2006 | Future Generation Computer Systems2006，22，： | 1 |
| 20 | <ce:link locator='fx1'/> Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells显示文摘 | Stuart A.C. McDonald Laura C. Greaves Lydia Gutierrez–Gonzalez Manuel Rodriguez–Justo Maesha Deheragoda Simon J. Leedham Robert W. Taylor Chung Yin Lee Sean L. Preston Matthew Lovell Toby Hunt George Elia Dahmane Oukrif Rebecca Harrison Marco R. Novelli I | 2008 | Gastroenterology2008，，2： | 1 |
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