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| 1 | Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease显示文摘AIM: To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole,bismuth subcitrate,furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens without success.METHODS: Open cohort study which included patients with peptic ulcer who had previously been treated unsuccessfully with one or more eradication regimens.The therapeutic regimen consisted of 20 mg omeprazole,240 mg colloidal bismuth subcitrate,1000 mg amoxicillin,and 200 mg furazolidone,taken twice a day for 7 d.Patients were considered as eradicated when samples taken from the gastric antrum and corpus 12 wk after the end of treatment were negative for Helicobacter pylori (H pylori) (rapid urease test and histology).Safety was determined by the presence of adverse effects.RESULTS: Fifty-one patients were enrolled.The eradication rate was 68.8% (31/45).Adverse effects were reported by 31.4% of the patients,and these were usually considered to be slight or moderate in the majority of the cases.Three patients had to withdraw from the treatment due to the presence of severe adverse effects.CONCLUSION: The association of bismuth,furazolidone,amoxicillin and a proton-pump inhibitor is a valuable alternative for patients who failed to respond to other eradication regimens.It is an effective,cheap and safe option for salvage therapy of positive patients. | Guilherme Eduardo Gonalves Felga Fernando Marcuz Silva Ricardo Correa Barbuti Tomás Navarro-Rodriguez Schlioma Zaterka Jaime Natan Eisig | 2008 | World Journal of Gastroenterology2008，14，40： | 9 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Glycine max (L.) Merr., Vigna radiata L. and Medicago sativa L. sprouts: A natural source of bioactive compounds显示文摘 | Luís R. Silva Maria J. Pereira Jessica Azevedo Rui F. Gon?alves Patrícia Valent?o Paula Guedes de Pinho Paula B. Andrade | 2013 | Food Research International2013，，1： | 2 |
| 5 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 6 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 7 | Expression of Survivin and its relationship to loss of apoptosis in breast carcinomas显示文摘 | Iwamoto S Gon G | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 8 | Expression of survivin and its relationship to loss of apoptosis in breast carcinomas显示文摘 | Tanaka K Iwamoto S Gon G | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 9 | Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo:a comparative study of bone contact and bone growth induction显示文摘 | Grandfield K Palmquist A Gon?alves S | | 0，，： | 1 |
| 10 | Advanced lung adenocarcinoma in an EGFR-positive patient treated with Erlotinib for 52 months显示文摘 | Ivone Gon?alves Inês Ladeira Ana Castro Ana Antunes Ana Barroso Bárbara Parente | 2013 | Respiratory Medicine Case Reports2013，，： | 1 |
| 11 | Detection of ethanol gas concentration by fuel cell sensors fabricated using a solid polymer electrolyte 显示文摘 | Kim K C Cho S M Choi H Gon | 2000 | Sensors and Actuators B2000，67，1： | 1 |
| 12 | Expression of sur- Vivin and its relationship to loss of apoptosis in breast car- cinomas显示文摘 | Tanaka K Iwamoto S Gon G | 2000 | Clin Cancer Res2000，6，： | 1 |
| 13 | Expression of survivin and its relationship to loss of apoptosis in breast carcinomas显示文摘 | Tanaka K Iwamoto S Gon G | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 14 | Expression of survivin and its relationship to loss of apoptosis in breast carcinomas显示文摘 | Tanaka K Iwamooto S Gon G | 2000 | Clin Cance Res2000，6，1： | 1 |
| 15 | Expression of survivin and its relationship to loss of apopotosis in breast carcinomas显示文摘 | Tanaka K Iwamooto S Gon G | | 0，，01： | 1 |
| 16 | p38 MAP kinase regulates TNF alpha-,IL-1 alpha-and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells显示文摘 | Hashimoto S Matsumoto K Gon Y | 2000 | Clin Exp Allergy2000，30，1： | 1 |
| 17 | Expression of Survivin and its relationship to loss apoptosis in breast cancinomas显示文摘 | Tanaka K Iwamoto S Gon G | 2000 | Clin Cancer Res2000，6，： | 1 |
| 18 | P38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells显示文摘 | Kujime K Hashimoto S Gon Y | 2000 | J Immunol2000，164，6： | 1 |
| 19 | Tubercular Mastitis-A Great Masquerader显示文摘 | Gon S Bhattacharyya A Majumdar B | 2013 | Turk Patoloji Derg2013，29，1： | 1 |
| 20 | Hyperglycaemia at admission in acute coronary syndrome patients:prognostic value in diabetics and non-diabetics显示文摘 | Monteiro S Monteiro P Gon?alves F | | 0，，： | 1 |
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