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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | Reporting and Methodological Quality of Systematic Reviews in the Orthopaedic Literature 显示文摘 | Gagnier JJ Kellam PJ | 2013 | J Bone Joint Surgery2013，95，： | 1 |
| 3 | Association between first inject risk behaviors and hepatitis C seropositivity among injecting drug users显示文摘 | Vidal - Trecan GM Varescon - Pousson I Gagniere B | 2002 | Ann Med Interne(Paris)2002，153，4： | 1 |
| 4 | Reporting randomized, controlled trials of herbal interventions: An elaborated CONSORT statement显示文摘 | Gagnier J | 2006 | Annals of Internal Medicine2006，144，5： | 1 |
| 5 | Risk analysis of Leukaemia incidence among people living along the Techa River :a nested case- control study显示文摘 | Ostroumova E B Gagniere D Laurier | 2006 | J Radiol Prot2006，26，1： | 1 |
| 6 | Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review显示文摘 | GAGNIER J J CHRUBASIK S MANHEIMER E | 2004 | BMC Complement Altern Med2004，4，： | 1 |
| 7 | Cocrystal formation in solu- tion: Inducing phase transition by manipulating the amount of cocrystallizing agent 显示文摘 | Gagniere E Mangin D Puel F | 2011 | J Cryst Growth2011，316，： | 1 |
| 8 | Management of synchronous colorectal liver metastases 显示文摘 | Dupre A Gagniere J Chen Y | 2013 | Bull Cancer2013，100，4： | 1 |
| 9 | 改进实效型试验的报告质量:CONSORT声明的扩充(2)显示文摘实效型试验旨在为临床实践决策提供依据,但报告得不好会降低其实用性。CONSORT和Practihc小组描述了对CONSORT指南的修改,帮助读者评估研究结果的适用性。 | Merrick Zwarenstein Shaun Treweek Joel J Gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) | 2009 | 英国医学杂志中文版2009，12，3： | 1 |
| 10 | Pharmacokineties of nevirapine in human immunodeficiency virus type-1-infected pregnant women and their neonates显示文摘 | Fenton T Gagnier P | 1998 | J Infect Dis1998，178，2： | 1 |
| 11 | Effects of clam- ping procedures on central venous pressure during liver re- section 显示文摘 | Gagniere J Le Roy B Antomarchi O | 2016 | J Visc Surg2016，153，2： | 1 |
| 12 | Reporting random- ized,controlled trials of herbal interventions : an elabo- rated CONSORT statement 显示文摘 | Gagnier JJ Boon H Rochon P | 2006 | Ann Intern Med2006，144，5： | 1 |
| 13 | Herbal medicine for low back pain显示文摘 | Gagnier JJ Van Tulder M Berman B | 2006 | Cochrane Database Syst Rev2006，，00： | 1 |
| 14 | First Canadian records of Aphis glycines 显示文摘 | HUNT D FOOT17T R GAGNIER D | 2003 | The Canadian Entomologist2003，135，6： | 1 |
| 15 | Comparative study of metabolic differentiation of foetal muscle in normal and double-muscled cattle 显示文摘 | GAGNIERE H PICARD B JURIE C | 1997 | Meat Science1997，45，： | 1 |
| 16 | Reporting Randomized,Controlled Trials of Herbal Interventions:An Elaborated CONSORT Statement显示文摘 | Joel J Gagnier Heather Boon Paula Rochon | 2006 | Annals of Internal Medicine2006，144，5： | 1 |
| 17 | The CARE guidelines: consensus-based clinical case report guideline evelopment 显示文摘 | GAGNIER JJ KIENLE G ALTMAN DG | 2013 | J Diet Suppl2013，10，4： | 1 |
| 18 | Dutasteride and bicalutamide in patients with hormone-refractory prostate cancer: the Therapy Assessed by Rising PSA (TARP) study rationale and design显示文摘 | Sartor O Gomella L G Gagnier P | 2009 | Can J Urol2009，16，5： | 1 |
| 19 | Quality of reporting of randomized controlled trials of herbal medicine interventions显示文摘 | GAGNIER JJ DEMELO J BOON H | 2006 | Am J Med2006，119，9： | 1 |
| 20 | Improving the quality of reporting of randomized controlled trials evaluating herbal interventions: implementing the CONSORT statement 显示文摘 | GAGNIER J BOON H ROCHON P | 2006 | Explore (NY)2006，2，2： | 1 |
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