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| 1 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 2 | Lamivudine therapy for children with chronic hepatitis B显示文摘瞄准:为了估计,为失败到的有长期的肝炎 B (CHB ) 的孩子的 lamivudine 治疗的有效性和副作用对作出回应或有禁止徵候到 interferon-alpha (IFN-alpha ) 治疗。方法:有 CHB 的 59 个孩子被对待, 100 片 mg lamivudine 药片每天为 12 瞬间口头上地给一次。丙氨酸 aminotransferase (中高音) 活动在它的中止以后在治疗和每 3 瞬间期间每月被评估。HBe 抗原, anti-HBe 抗体,在浆液的 HBV DNA 水平在基线和每六个月被评估在期间并且在 lamivudine 治疗以后。对 lamivudine 治疗的持续病毒的反应(SVR ) 被定义为永久(比在治疗的结束以后的 6 瞬间不短) ,也就是中高音活动正规化,到 anti-HBe 抗体的 HBeAg 的 seroconversion,和在浆液的无法发现的病毒的 HBV-DNA (比 200 个拷贝低每 mL ) 。lamivudine 治疗的副作用的分析有关测试在治疗以后在治疗,和每 3 瞬间期间每月在临床的访问期间执行了的主观、客观的症状,临床的考试,和实验室用一张问询表在病人和他们的父母的会见之上被基于。结果:中高音 normalisation 发生在 47 (79.7%) 病人在之间第一和 11 (th ) 治疗的瞬间(吝啬的 4.4+/-2.95 瞬间,中部 4.0 瞬间) ,并且在 18 (30.5%) 他们在治疗的 2 瞬间以后。在中高音正规化和孩子们的年龄的时间之间没有关联, HBV 感染的年龄, HBV 感染的持续时间,发炎活动分数(分级) ,阶段,在治疗前的中高音活动,浆液 HBV DNA 水平,和 lamivudine 每体重的 kg 开。HBeAg/anti HBe seroconversion 在 27.1% 盒子中被完成。seroconversion 的更高的率与更低的浆液 HBV DNA 水平和 HBV 感染的更长的持续时间被连接。在 HBeAg/anti HBeAb seroconversion 和孩子们之间没有连接,分级是年龄, HBV 感染的年龄,阶段,在治疗前的中高音活动,和 lamivudnie 每体重的 kg 开。没有抱怨或临床的症状在 lamivudine 治疗期间被观察。肾的功能或骨髓中毒的效果的缺陷病人在没有被注意。结论:为有长期的肝炎 B 的孩子的一年 lamivudine 治疗有效、很好容忍。HBeAg/HBeAb 和 SVR 的 Seroconversion 与更低的预告的处理浆液 HBV DNA 水平被连接。 | Anna Liberek Anna Szaflarska-Poplawska Maria Korzon Gra(?)yna (?)uczak Magdalena Góra-Gebka Ewa (?)o(s|')-Rycharska Wanda Bako Mieczyslawa Czerwionka-Szaflarska | 2006 | World Journal of Gastroenterology2006，12，15： | 4 |
| 3 | Transformation of wheat with high molecular weight subunit genes results in improved functional properties显示文摘 | Barro F Rooke L Bekes F Gras P Tatham A S Fido R Lazzeri P A Shewry P R Barcelo P | 1997 | Nat Biotechnol1997，15，12： | 2 |
| 4 | Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8 T-cell re- sponses显示文摘 | Day E B Guillonneau C Gras S | 2011 | Proc Natl Acad Sci USA2011，108，23： | 1 |
| 5 | T cell aUorecognition via molecular mimicry显示文摘 | Macdonald WA Chen Z Gras S | 2009 | Immunity2009，31，6： | 1 |
| 6 | T-cell receptor bias and immunity显示文摘 | Gras S Kjer-Nielsen L Burrows SR | 2008 | Curr Opin Immunol2008，20，1： | 1 |
| 7 | Next generation sequencing for molecular diagnosis of neuromuscular diseases显示文摘 | Vasli N Bihm J Le Gras S | 2012 | Acta Neuropathol2012，124，2： | 1 |
| 8 | A dose?response analysis of the reproductive effects of a single gestational dose of 2 ,3 ,7 ,8 -tetrachlorodibenzo?p-dioxin in male Long Evans Hooded rat offspring显示文摘 | GRA Y L E OSTBYJ S KELCE W R | 1997 | Toxicol Appl Pharmacol1997，146，1： | 1 |
| 9 | Developmem and validation of a method for the simultaneous extraction and separate measurement of oxytetracycline, florfenicol, oxolinic acid and flumequine from marine sediments 显示文摘 | NORAMBUENA L GRAS N CONTRERAS S | 2013 | Marine Pollu- tion Bulletin2013，73，1： | 1 |
| 10 | 4-year experience of Biventricutar pacing for congestive heart failure显示文摘 | Cazeau S Lectcrcq C Gras D | 1998 | Pacing Clin Electrophysiol1998，21，： | 1 |
| 11 | Effect of varying protein content and glutenin-to-gliadin ration the functional properties of wheat dough显示文摘 | Uthayakumaran S Gras P W Stoddard F L | 1999 | Cereal Chemistpy1999，76，3： | 1 |
| 12 | Starch modification by iterated syneresis显示文摘 | GRA(Z)YNA L MARIA S(S) | 2004 | Carbohydrate Polymers2004，56，4： | 1 |
| 13 | International Global At- mospheric Chemistry (IGAC) project' s First Aerosol Characteriza- tion Experiment ( ACE 1 ) : Overview 显示文摘 | Bates T S Huebert B J Gras J L | 1998 | J Geophys Res1998，103，16： | 1 |
| 14 | A bistatic SAR mission for earth observation on based of a small satellite显示文摘 | D'ERRICO M GRAS M VETRELLA S | 1996 | Acta Astronautica1996，39，912： | 1 |
| 15 | Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes显示文摘 | Trujillo JA Gras S Twist KA | 2014 | J Immunol2014，192，11： | 1 |
| 16 | Effects of incorporated glutenins on functional properties of wheat dough 显示文摘 | Uthayakumaran S Stoddard F L Gras P W | 2000 | Cereal Chem2000，77，6： | 1 |
| 17 | Screening for high - yielding Pichia pastoris clones: the production of G protein - cou- pled receptors as a case study显示文摘 | SINGH S GRAS A FIEZ -VANDAL C | 2012 | Methods Mol Biol2012，866，： | 1 |
| 18 | Preparation of double emulsions by membrane emulsification-a eview 显示文摘 | Van der Gra~ S Schroen CGPH Boom RM | 2005 | Journal of Membrane Science2005，251，12： | 1 |
| 19 | Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti- fibrotic strategies显示文摘 | Hemmann S Gra f J Roderfeldl M | 2007 | J Hepatol2007，46，： | 1 |
| 20 | Thermodynamic and kinetic studies for synthesis of the acetal(1,1-diethoxybutane)catalyzed by amberlyst 47 ion-exchange resin显示文摘 | Rahaman M Gra?a N S Pereira C S M | 2015 | Chem Eng J2015，264，3： | 1 |
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