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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Lung cancer histology,stage,treatment,and survival in American Indians and Alaska Natives and whites显示文摘 | FESINMEYER M D GOULART B BLOUGH D K | 2010 | Cancer2010，116，20： | 1 |
| 3 | Opti- mization over state feedback policies for robust control with con- straints 显示文摘 | GOULART P J KERRIGAN E C MACIEJOWSK/ J M | 2006 | Automatica2006，42，4： | 1 |
| 4 | Major increase in brain natriuretic Peptide indicates right ventricular systolic dysfunction in patients with heart failure显示文摘 | MARIANO GOULART D EBEDE M C BOUDOUSQ V | 2003 | Eur J Heart Fail2003，5，4： | 1 |
| 5 | Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels 显示文摘 | GOULART B K DE LIMA M N DE FARIAS C B | 2010 | Neuroscienee2010，167，4： | 1 |
| 6 | Effect of chemical modification on mechanical behaviour of polypropylene reinforced pineapple crown fibers composites显示文摘 | Sipiao B L S Paiva R L M Goulart S A S | 2011 | Procedia Engineering2011，10，： | 1 |
| 7 | Electrochemical capacitor using polymer/carbon composite electrode 显示文摘 | PERNAUT J M GOULART G | 1995 | Journal of Power Source1995，55，1： | 1 |
| 8 | Electrochemical capacitor using polymer/carbon composites 显示文摘 | Goulart G | 1995 | J Power Source1995，55，： | 1 |
| 9 | Foot and ankle fractures in dancers 显示文摘 | Goulart M O'Malley M J Hodgkins C W | 2008 | Clin Sports Med2008，27，2： | 1 |
| 10 | Postneonatal infant mortality and quality of medical care: a case-control study 显示文摘 | Mendonca E F Goulart E M A | 2001 | Journal de Pediatria2001，77，6： | 1 |
| 11 | Association between psoriasis and coronary calcium score显示文摘 | Henrique L. Staniak Márcio Sommer Bittencourt Itamar de Souza Santos Rodolfo Sharovsky Cid Sabbag Alessandra C. Goulart Paulo A. Lotufo Isabela M. Bense?or | 2014 | Atherosclerosis2014，，： | 1 |
| 12 | Effect of Chemical Modification on Mechanical Behaviour of Polypropylene Reinforced Pineapple Crown Fibers Composites 显示文摘 | Sipiao B L S Paiva R L M Goulart S A S | 2011 | Proeedia Engineering2011，10，： | 1 |
| 13 | Effect of dendritic arm spacing on mechanical properties and corrosion resistance of Al-9 wt pct Si and Zn-27 wt pet Al alloys 显示文摘 | OSARIO W R GOULART P R SANTOS G A NETCO C M GARCIA A | 2006 | Metallurgical and Materials Transactions A2006，37，： | 1 |
| 14 | Electrochemi- cal study of methyl 2-- acrylate, an anticancer drug, In the presence of GSH and dsD- NA 显示文摘 | Marilia O F Goulart A A de Souza E M Sales | 2007 | ECS Transactions2007，3，29： | 1 |
| 15 | Numerical simulation of flow and dispersion around an isolated cubical building:the effect of the atmospheric stratification显示文摘 | Santos J M Reis NC Jr Goulart E V | 2009 | Atmospheric Environment2009，43，34： | 1 |
| 16 | Informatics applied to cytology显示文摘 | Pantanowitz L Homish M Goulart RA | 2008 | CytoJoumal2008，5，： | 1 |
| 17 | Toward less sedation in the intensive care unit:A prospective observational study显示文摘 | Salgado D R Favory R Goulart M | | 0，，02： | 1 |
| 18 | The application of electrochemical technology to the remediation of oily wastewater显示文摘 | SANTOS M R G GOULART M O F TONHOLO J | 2006 | Chemosphere2006，64，： | 1 |
| 19 | Biodiversity assessment of benthic macroinvertebrate along a reservoir cascade in the lower Sáo Francisco river(northeastern Brazil)显示文摘 | Callisto M Goulart M Barbosa F A R | | 0，，02： | 1 |
| 20 | Lipoperoxidation products and thiol antioxidants in chromium exposed workers显示文摘 | Goulart M Batoreu MC Rodrigues AS Laires A Rueff J | 2005 | Mutagenesis2005，20，5： | 1 |
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