|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum显示文摘 | Gomez B Jr Ardakani S Ju J | 1995 | Clin Chem1995，4111，： | 1 |
| 4 | Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFRI显示文摘 | Gomez MI Lee A Reddy B | 2004 | Nat Med2004，10，8： | 1 |
| 5 | Nonablative radiofrequency for active acne vulgaris:the use of deep dermal heat in the treatment of maderate to severe active acne vulgaris(thermotherapy):a report of 22 patients显示文摘 | RUIZ-ESPARZA J GOMEZ J B | 2003 | Dermatol Surg2003，29，4： | 1 |
| 6 | Dementia in Parkinson disease: a proton magnetic resonance specroscpy study显示文摘 | Summerfield C Gomez Anson B Tolosa E | 2002 | Arch Neurol2002，59，9： | 1 |
| 7 | Highly turbulentcounterflow flames : A laboratory scale benchmark forpractical systems 显示文摘 | Coppola G Coriton B Gomez A | 2009 | Combustion and Flame2009，156，： | 1 |
| 8 | Electrical Conduction Mechanism in Chemically Derived Graphene Monolayers显示文摘 | Kaiser A B Gomez Navarro C Sundaram R S | 2009 | Nano Letters2009，9，5： | 1 |
| 9 | Clinical trial:a nutritional supplement Viusid,in combination with diet and exercise,in patients with nonalcoholic fatty liver disease显示文摘 | Vilar gomez E Rodriguez de miranda A Gra oramas B | | 0，，10： | 1 |
| 10 | Soft wheat instead of hard wheat in pelleted diets results in high starch digestibility in broiler chickens显示文摘 | Carte B Muley N Gomez J | 2005 | Br Poult Sci2005，46，1： | 1 |
| 11 | Extending Applicability of the Oxygen Radical Absorbance capacity(ORAC2Fluorescein)Assay显示文摘 | Davalos A Gomez C C Bartolome B | 2004 | J Agric Food Chem2004，52，1： | 1 |
| 12 | Matching Compensation and Organization Strategies 显示文摘 | David B Balkin Gomez Mejia | 1990 | Strategic Management Journal1990，，11： | 1 |
| 13 | Production of glutamyl polypeptide by Bacillus subtilis 显示文摘 | Thorne C B Gomez C G Noyes H E | 1954 | J Bacteriol1954，68，： | 1 |
| 14 | Toward a contingency theory of compensation strategy 显示文摘 | BALKIN D B GOMEZ - MEJIA L R | 1987 | Strategic Management Journal1987，8，2： | 1 |
| 15 | Weather, climate and tourism: A geographical perspective显示文摘 | Gomez Martin Ma B | 2005 | Annals of Tourism Research2005，32，3： | 1 |
| 16 | Carbopol as a model fluid for studying mixing of pulp fibre suspensions 显示文摘 | Gomez C Derakhshandeh B Hatzikiriakos S G | 2010 | Chemical Engineer- ing Science2010，65，3： | 1 |
| 17 | Affective computing-a rationale for measuring mood with mouse and keyboard显示文摘 | Zimmermann P Guttormsen S Danuser B Gomez P | | 0，，04： | 1 |
| 18 | Plant identification based on leaf midrib cross - section images using fractal descriptors显示文摘 | SILVA N R D FLORINDO J B GOMEZ M C | 2015 | PLoS One2015，10，01： | 1 |
| 19 | Imaging in the evaluation of blunt Pancreatic trauma显示文摘 | Gomez MA Besson M Scotto B | 2004 | J Radiol2004，85，4： | 1 |
| 20 | Violent crime and outdoor physical activity among inner-city youth显示文摘 | GOMEZ J E JOHNSON B A SELVA M | 2004 | Prey Med2004，39，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员