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| 1 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 2 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 3 | Laparoscopic radical cystoprostatectomy with ileal conduit performed completely intracorporeally:the initial 2 cases显示文摘 | Gill IS Fergany A Klein EA | 2000 | Urology2000，，01： | 2 |
| 4 | Some simple solutions for heat-induced tropical circulation显示文摘 | GILL A E | 1980 | Quart J Roy Meteor Soc1980，106，： | 1 |
| 5 | Protein, lipid, water and caloric contents of immature rainbow trout, Salmo gairdneri, growing at different rates显示文摘 | Weatherley A H Gill H S | 1983 | J Fish Biol1983，23，： | 1 |
| 6 | Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation显示文摘 | Jamnongjit M Gill A Hammes S R | 2005 | Proc Natl Acad Sci U S A2005，102，16： | 1 |
| 7 | Thermal degradation of partially purified paralytic shellfish poison toxins at different times, temperature andpH 显示文摘 | INDRASENA W M GILL T A | 2000 | Journal of Food Science2000，65，6： | 1 |
| 8 | Structural characterization of a pentosan from the water-in soluble portion durum wheat endosperm显示文摘 | Medcalf D C Gilles K A | 1968 | Cereal Chem1968，45，6： | 1 |
| 9 | The use of the holmium laser in the treatment of benign prostatic hyperplasia显示文摘 | Gilling P J Cass C B Malcolm A R | 1998 | Urology1998，51，： | 1 |
| 10 | Vitamin D3-up-regulated protein is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin 显示文摘 | Wang A Gilles W Keulenaer D | 2002 | J Biol Chem2002，277，26： | 1 |
| 11 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles K A Hamilton J K | 1956 | Anal Chem1956，28，： | 1 |
| 12 | Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritime显示文摘 | NELSON K E CLAYTON R A GILL S R | 1999 | Nature1999，399，： | 1 |
| 13 | Tissue - specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia显示文摘 | Slaugenhaupt SA Blumenfeld A Gill SP | 2001 | Am J Hum Genet2001，68，3： | 1 |
| 14 | Localization, characterization andpartial purification of TMAO-ase 显示文摘 | Gill T A Paulson A T | 1982 | ComparatiiveBioehemistry and Physiology1982，71，： | 1 |
| 15 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles KA Hamihon JK et a/ | 1956 | Analytical Chemistry1956，28，3： | 1 |
| 16 | A placebo- controlled study of liposome - mediated gene transfer to the nasal ep- ithelium of patients with cystic fibrosis显示文摘 | GILL D R SOUTHERN K W MOFORD K A | 1997 | Gene Ther1997，4，3： | 1 |
| 17 | Rescue of a human mRNA splicing defect by the plant cytokinin kinetin显示文摘 | Slaugenhaupt S A Mull J Leyne M Cuajungco M P Gill S P Hims M M Quintero F Axelrod | | 0，，04： | 1 |
| 18 | Using simple environmental variables to estimate below-ground productivity in grasslands显示文摘 | Gill R A Kelly R H Parton W J | | 0，，01： | 1 |
| 19 | Identification of a gene,MLL,that spans the breakpoint in 11q23 translocations associated with human leukemias显示文摘 | Ziemin-Van Der Poel S McCabe NR Gill HJ Espinosa R 3rd Patel Y Harden A Rubinelli P Smith SD LeBeau MM Rowley JD | | 0，，： | 1 |
| 20 | The Montreal cognitive assessment as a screening tool for cognitive impairment in Parkinson’s disease显示文摘 | Gill DJ Freshman A Blender JA | 2008 | Mov Disord2008，23，7： | 1 |
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