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| 1 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 2 | Prechemotherapy serum levels ofCDios, transforming growth factor beta2, and vascular endothelialgrowth factor are associated with prognosis io patients with ad-vanced epithelial ovarian cancer treated with cytoreductive surgeryand platinum-based chemotherapy 显示文摘 | Bozas G Terpos E Gika D | 2010 | Int J Gynecol Cancer2010，20，2： | 1 |
| 3 | Liquid chromatography - mass spectrometry based global metabolite profiling : a review 显示文摘 | Theodoridis GA Gika HG Want E J | 2012 | Anal Chim Acta2012，711，20： | 1 |
| 4 | Brain metastases as isolated site of relapse in patients with epithelial ovarian cancer previously treated with platinum and paclitaxel-based chemotherapy显示文摘 | Kastritis E Efstathiou E Gika D | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
| 5 | Simultaneous determination of terbuthylazine and its major hydroxy and dealkylated metabolites in wetland water samples using solid-phase extraction and high-performance liquid chromatography with diode-array detection 显示文摘 | Papadopoulos N Gikas E Zalidis G | 2007 | Journal of Agricultural and Food Chemistry2007，55，18： | 1 |
| 6 | Osteonecrosis of the jaw in cancer after treatment with bisphosphonates:incidence and risk factors显示文摘 | Bamias A Kastritis E Bamia C Moulopoulos LA Melakopoulos I Bozas G Koutsoukou V Gika D Anagnostopoulos A Papadimi-triou C Terpos E Dimopoulos MA | | 0，，： | 1 |
| 7 | Global metabolic profiling procedures for urine using UPLC - MS 显示文摘 | Want E J Wilson I D Gika H | 2010 | Nat Protoc2010，5，6： | 1 |
| 8 | Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates:evidence of increased risk after treatment with zoledronic acid显示文摘 | Dimopoulos MA Kastritis E Anagnostopoulos A Melakopoulos I Gika D Moulopoulos LA Bamia C Terpos E Tsionos K Bamias A | | 0，，： | 1 |
| 9 | Effects of chro- mium on activated sludge and on the per- formance of wastewater treatment plants: a review 显示文摘 | Vaiopoulou E Gikas P | 2012 | Water Res2012，46，： | 1 |
| 10 | Brain metastases as iso?lated site of relapse in patients with epithelial ovarian cancer previ?ously treated with platinum and paclitaxel-based cbemotherapy显示文摘 | Kastritis E Efstathiou E Gika D | 2006 | IntJGynecol Cancer2006，16，3： | 1 |
| 11 | Evaluation of the repeatability of ultra-performance liquid chromatography - TOF-MS for global metabolic profiling of human urine samples 显示文摘 | Gika H G Macpherson E Theodoridis G A | 2008 | J Chromatogr B2008，871，2： | 1 |
| 12 | Effects of chromium on activated sludge and on the performance of wastewater treatment plants:a review显示文摘 | Vaiopoulou E Gikas P | 2012 | Water Research2012，46，3： | 1 |
| 13 | Evo- lution of aminoglycoside resistance phentypes of fourgram-negative bacteria:an 8-year survey in a university hospital in Greece显示文摘 | NEONAKIS I GIKAS A SCOULICA E | 2003 | International Journal of Antimicrobial Agents2003，22，5： | 1 |
| 14 | Gas chroma- tographic -tandem mass spectrometric method for the quantitation of carbofuran, carbaryl and their main metabolites in applicators'u- rine 显示文摘 | Petropoulou S S E Gikas E Tsarbopoulos A | 2006 | Journal of Chromatography A2006，1108，1： | 1 |
| 15 | Determination of Isoflavones in the Aerial Part of Red Clover by HPLC-Diode Array Detection 显示文摘 | Gikas E Alesta A Economou G | 2008 | Journal of' Liquid Chromatography & Related Technologies2008，31，8： | 1 |
| 16 | Evaluation of the repeatability of ultra-performance liquid chromatography-TOF-MS for global metabolic profiling of human urine samples显示文摘 | Gika HG Macpherson E Theodoridisa GA | 2008 | J Chromatogr B2008，871，： | 1 |
| 17 | Effects of chromium on activated sludge and on the performance ofwastewater treatment plants: A review 显示文摘 | Vaiopoulou E Gikas P | 2012 | Water Research2012，46，3： | 1 |
| 18 | Evolution of aminoglycoside resistence phenotypes of four gram negative bacteria:an 8 year survey in a university hos pital in Greece显示文摘 | Neonakiso I Gikas A Scoulica E | 2003 | Int J Antimicrob Agents2003，22，5： | 1 |
| 19 | Use of notched boreholes for fracture controlled blasting in the orna- mental stone quarries显示文摘 | Tsoutrelis C E Gikas N Nomikos P | 1997 | Fragblast1997，1，4： | 1 |
| 20 | Hydroxytyrosol : A compound from nature's arsenal against metabolic syndrome 显示文摘 | Lemonakis N Gikas E Poudyal H | 2012 | Planta Medica2012，78，11： | 1 |
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