|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Purification and identification of potentially bioactive peptides from enzyme-modified cheese显示文摘 | S S HA ILESELASSIE B H LEE B F GIBBS | 1999 | Journal of Dairy Science1999，82，8： | 1 |
| 3 | Effect of turning regime and seasonal weather conditions on nitrogen and phosphorus losses during aerobic composting of cattle manure 显示文摘 | Parkinson R Gibbs P Burehett S | 2004 | Bioresource Technology2004，91，： | 1 |
| 4 | Contributing factorsin construction accidents 显示文摘 | HASLAM R A HIDE S A GIBB A G F | 2005 | Applied Ergonomics2005，36，40： | 1 |
| 5 | Deletion screening of the duchenne muscular dystrophy locus via multiplex DNA amplification 显示文摘 | CHAMBERLAIN J S GIBBS R A RANIER J E | 1988 | Nucleic Acids Res1988，16，23： | 1 |
| 6 | Novel statistical tools for monitoring the safety of marketed drugs显示文摘 | Almenoff J S Pattishall E N Gibbs T G | 2007 | Clin Pharmacol Ther2007，82，2： | 1 |
| 7 | Localization of phycoerythrin at the lumennal surface of the thylakoid membrance in Rhodo- monas lens 显示文摘 | Ludwig M Gibbs S P | 1989 | The Journal of Cell Biology1989，108，： | 1 |
| 8 | Peripheral enhanced and spatial contrast uptake heterogeneity of primary breast tumors: quantitative assessment wit b dynamic MRI 显示文摘 | Mussurakis S Gibbs P Horsman A | 1998 | J Comput Assist Tomogr1998，22，： | 1 |
| 9 | Impact of air staging on the fate of NO and N2O in a circulating fluidized-bed combustor 显示文摘 | Wang X S Gibbs B M Rhodes M J | 1994 | Combustion and Flame1994，99，34： | 1 |
| 10 | Structural interactions between Kisspeptin and GnRH neurons in the me- diobasal hypothalamus of the male rhesus monkey (Maeaca mulatta) as revealed by double immunofluoreseenee and eonfo-al microscopy 显示文摘 | Ramaswamy S Guerriero K A Gibbs R B | 2008 | Endocrinology2008，149，9： | 1 |
| 11 | Local treatments for cutaneous waits:systematic review显示文摘 | Gibbs S Harvey I Sterling J | 2002 | BMJ2002，325，7362： | 1 |
| 12 | Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator显示文摘 | Zondlo S Gibbs S | 2004 | Lipid Res2004，45，8： | 1 |
| 13 | Detection screening of the duchenne muscular dystrophy locus via mutiplex DNA amplification显示文摘 | Chambercian J S Gibbs R A Ranier J E | 1988 | Nucl Acids Res1988，16，： | 1 |
| 14 | Valuation of Options on Several Underlying Assets显示文摘 | Evnine J Gibbs S | 1988 | Journal Financial and Quantitative Anal1988，23，1： | 1 |
| 15 | Monitoring systemic donor lymphocyte macroehimerism to aid the diagnosis of graft-versus-host disease after liver transplantation 显示文摘 | Taylor AL Gibbs P Sudhindran S | 2004 | Transplantation2004，77，3： | 1 |
| 16 | The relationship between infections and adverse pregnancy outcomes: an overview 显示文摘 | Gibbs R S | 2001 | Ann Periodontol2001，6，1： | 1 |
| 17 | Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal cancer显示文摘 | CAWTHORN S J PARUMS D V GIBBS N M | 1990 | Lancet1990，335，： | 1 |
| 18 | Cadmium availability to wheat grain in soils treated with sewage sludge or metal salts显示文摘 | Mc Grath S Gibbs P | 2007 | Chenmsphere2007，66，： | 1 |
| 19 | Fine structure of the human FMR1 gene显示文摘 | Eichler EF Richards S Gibbs RA | 1993 | Hum Mol Genet1993，2，： | 1 |
| 20 | Monitoring systemic donor lymphocyte rnaeroehimerism to aid the diagnosis of graft-versus-host disease after liver transplantation 显示文摘 | Taylor AL Gibbs P Sunhindran S | 2004 | Transplantation2004，77，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员