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| 1 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 2 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 3 | Testing to Fulfill HACCP (Hazard Analysis Critical Control Points)Requirements:Principles and Examples 显示文摘 | Gardner I A | 1997 | J dairy Sci1997，80，： | 1 |
| 4 | MT-stabilizer, dic-tyostatin, exhibits prolonged brain retention and activity:potential therapeutic implications显示文摘 | Brunden KR Gardner NM James MJ Yao Y Trojanowski JQ Lee VM-Y Paterson I Ballatore C Smith III AB | | 0，，： | 1 |
| 5 | Design, modelling and test results of the AWS PM linear generator 显示文摘 | PPLINDER I H DAMEN M E C GARDNER F | 2005 | Euro Trans Electr Power2005，15，： | 1 |
| 6 | A B-spline finite element method for the regularized long wave equation显示文摘 | Gardner L R T Gardner G A Dag I | 1979 | Comput methods Appl mecheng1979，20，： | 1 |
| 7 | Integrating resilience thinking and optimization for conservation显示文摘 | Fischer J Peterson GD Gardner TA Gordon L J Fazey I Elmqvist T Felton A Folke C Dovers S | | 0，，： | 1 |
| 8 | Spectroscopic studies of the structures of butyl and bromobutyl rubbers显示文摘 | Cheng D M Gardner I J Wang H C | 1990 | Rubber Chemistry and Technology1990，63，2： | 1 |
| 9 | Mycorrhizae of actionrhizalplants显示文摘 | Gardner I C | 1986 | MIRCEN Journal of Applied Microbiology and Biotechnology1986，2，1： | 1 |
| 10 | Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer显示文摘 | Beaujean N Taylor J Gardner J Wilmut I Meehan R Young L | 2004 | Biology of Reproduction2004，71，1： | 1 |
| 11 | LGE and NT-proBNP identify low risk of death or arrhythmic events in patients with primary prevention ICDs显示文摘 | Mordi I Jhund PS Gardner RS | 2014 | JACC Cardiovasc Imaging2014，7，6： | 1 |
| 12 | A B-spline finite element method for the RLW equation 显示文摘 | GARDNER L R T GARDNER G A DAG I | 1995 | Communications in Numerical Methods in Engineering1995，11，： | 1 |
| 13 | Immobilization and physiological parameters associated with chemical restraint of wild pigs with Telazol and xylazine hydrochloride显示文摘 | SWEITZER R A GHNEIM G S GARDNER I A | 1997 | Journal of Wildlife Diseases1997，32，2： | 1 |
| 14 | Geochemistry, mineralogy and geology of the Janson Pb - Zn deposits, Macmillan Pass, Yukon, Canada 显示文摘 | Gardner H D Hutchinson I | 1985 | Economic Geology1985，80，： | 1 |
| 15 | A complex adenovirus vaccine againstchikungunya virus provides complete protection against viraemia and arthritis 显示文摘 | Wang D Suhrbicr A Penn-Nicholson A Woraratanadharm J Gardner J Luo M Le TT Anraku I Sakalian M Einfeld D Dong JY | 2011 | Vaccine2011，29，15： | 1 |
| 16 | Comparison of sampling and culture methods for the diagnosis of Tritrichomonas foetus infection in bulls 显示文摘 | SchOnmann M J BonDurant R H Gardner I A | 1994 | Vet Rec1994，134，24： | 1 |
| 17 | Babesia gibsoni infections in dogs 显示文摘 | Yamane I Conrad P Gardner I | 1993 | J Protozool Res1993，3，： | 1 |
| 18 | A 2nd RF system for Nimrod显示文摘 | Sandels E G Church R A Gardner I S K | 1973 | IEEE Trans Nucl Sci1973，20，3： | 1 |
| 19 | Conditional dependence between tests affects the diagnosis and surveillance of animal diseases显示文摘 | Gardner I A Stryhn H Lind P | 2000 | Prevent Vet Med2000，45，12： | 1 |
| 20 | Interpolation in Digital Modems-Part Ⅱ: Implementation and Performance显示文摘 | Erup I Gardner F M Harris R A | 1993 | IEEE Transcations on Communications1993，41，6： | 1 |
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