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| 1 | Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes显示文摘INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7]. | Ru Tao Cui~1 Gan Cai~2 Zhao Bao Yin~(2*) Yong Cheng~2 Qiu Hong Yang~1 Tao Tian~(3#) ~1Liver Center,Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences~2Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China and Department of Pathophysiology.Shanghai Medical University.Shanghai,China ~3Pathological Department,Shanghai Medical University (?)Now working at UCLA,USA ~#Now working at University of Michigan,USADr.Ru Tao Cui graduated and got the bachelor degree from Shandong University of Traditional Chinese Medicine in 1994,got doctor degree from Shanghai University of Traditional Chinese Medicine in 2000,now studying as a postdoc,majoring gastroenterology,having 29 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 2 | Medical student depression and its correlates across three international medical schools显示文摘BACKGROUND Medical students have high rates of depression, anxiety, and burnout that have been found to affect their empathy, professional behaviors, and performance as a physician. While studies have examined predictors for burnout and depression in the United States (US), no study, to our knowledge, has compared depression in medical students cross-culturally, or has attempted to examine the effect of factors influencing rates including burnout, exercise, stress, unmet mental health needs, and region. AIM To examine rates of depression in three international cohorts of medical students, and determine variables that may explain these differences. METHODS Convenience samples of medical students from three countries (US, China, and a Middle Eastern country whose name remains anonymous per request from the school) were surveyed in this observational study. Using the Patient Health Questionnaire-2 (PHQ-2) and a modified Maslach Burnout Inventory, depression and burnout were examined among medical students from the three cohorts (n = 473). Chi-square test and analysis of variance were used to examine differences in demographics, behavioral, and psychological variables across these three schools to identify potentially confounding descriptive characteristics. Analysis of covariance compared depression and the emotional exhaustion component of burnout identified through Principal Component Analysis across countries. Multiple linear regression was used to analyze the impact of demographic, behavioral, and psychological variables on screening positive for depression. RESULTS Medical students from the Middle Eastern country had the highest rates of positive depression screens (41.1%), defined as a PHQ-2 score of ≥ 3, followed by China (14.1 %), and then the US (3.8%). More students in the Middle Eastern school had unmet mental health needs (50.8%) than at the medical school in China (34.8%) or the school in the US (32.8%)(Pearson chi-square significance < 0.05). Thus, PHQ-2 scores were adjusted for unmet mental health needs;however, the Middle Eastern country continued to have the highest depression. Adjusting for PHQ-2 score, medical students from the US scored the highest on emotional exhaustion (a measure of burnout). Demographic variables did not significantly predict medical student depression;however, lack of exercise, unmet mental health needs, stress, and emotional exhaustion predicted nearly half of depression in these cohorts. In comparison to the US, coming from the Middle Eastern country and China predicted higher levels of depression. CONCLUSION Depression rates differ in three international cohorts of medical students. Measured factors contributed to some observed differences. Identifying sitespecific prevention and intervention strategies in medical student mental health is warranted. | Jessica A Gold Xinran Hu Gan Huang Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Mickey Trockel Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Robert M Rohrbaugh Kirsten M Wilkins | 2019 | World Journal of Psychiatry2019，9，4： | 2 |
| 3 | Emulation of neutron irradiation effects with protons: validation of principle显示文摘 | G.S Was J.T Busby T Allen E.A Kenik A Jensson S.M Bruemmer J Gan A.D Edwards P.M Scott P.L Andreson | 2002 | Journal of Nuclear Materials2002，，2： | 2 |
| 4 | Relationship of adiponectin with insulin sensitivity in humans, independent of lipid availability 显示文摘 | Furler S M Gan S K Poynten A M | 2006 | Obes Res2006，14，2： | 1 |
| 5 | Effect of β-sitosterol, a plant sterol, on growth, protein phosphatase 2A and phospholipida D in LNCaP cells显示文摘 | Awad A B Gan Y Fink C S | 2000 | Nutr Cancer2000，36，： | 1 |
| 6 | 显示文摘 | Percheron-Guégan A Lartigue G Achard J C | 1980 | J Less-Common Met1980，74，： | 1 |
| 7 | Association between chronic obstructive pulmonary disease and systemic in flammation:a systematic review and a meta-analysis显示文摘 | Gan WQ Man SFP Senthilselvan A | 2004 | Thorax2004，59，： | 1 |
| 8 | 1,8-Naphthalimides for non-doping OLEDs:the tunable emission color from blue,green to red显示文摘 | Gan J A Song Q L Hou X Y | 2004 | J Photochem Photobiol A:Chem2004，162，： | 1 |
| 9 | 显示文摘 | Latroche M Rodiguez-Carvajal J Percheron-Guégan A | 1995 | J Alloys Comp1995，218，： | 1 |
| 10 | Y-junction carbon nanotubes grown by in situ evaporated copper catalyst显示文摘 | GAN B AHN J ZHANG Q RUSLI YOON S F YU J HUANG Q F CHEW K LIGATCHEV V A ZHANG X B LI W Z | 2001 | Chem Phys Lett2001，333，： | 1 |
| 11 | Bispectral index monitoring al- lows her emergence and inproved recovery from propofol alfcntanil and nitrous oxide anesthesia BIS Utility Study Group显示文摘 | Gan TJ Class PS Windoor A | 1997 | Anesthe- siology1997，87，： | 1 |
| 12 | Goal-directed intraoperative fluid administration reduces length of hospital stay after major sur- gery 显示文摘 | Gan TJ Soppitt A Maroof M | 2002 | Anesthesiology2002，97，2： | 1 |
| 13 | 查看详情显示文摘 | Velayutham T S Abd Majid W H Gan W C Khorsand Zak A et at | | 0，，05： | 1 |
| 14 | New formulations of bupivacaine for the treatment of postoperative pain:liposomal bupivacaine and SABER-Bupivacaine显示文摘 | Skolnik A Gan TJ | 2014 | Expert Opin Pharmacother2014，15，11： | 1 |
| 15 | Consensus guide- lines for the management of postoperative nausea and vomiting显示文摘 | GAN T J DIEMUNSCH P HABIB A S | 2014 | Anesth Analg2014，118，10： | 1 |
| 16 | Exercise Increases Adiponectin Levels and Insulin Sensitivity in Humans显示文摘 | Gan S K Poynten A M | 2004 | Dia-betes Care2004，27，7： | 1 |
| 17 | High frequency of germinal centre derivation in diffuse large B cell lymphoma from Asian patients显示文摘 | Shia A K H Gan G G Jairaman S | 2005 | J Clin Pathol2005，58，9： | 1 |
| 18 | Influence of grazing on hydraulic and mechanical properties of semiarid steppe soils under different vegetation type in Inner Mongolia,China显示文摘 | Reszkowska A Krümmelbein J Peth S Horn R Zhao Y Gan L | | 0，，： | 1 |
| 19 | Association between chronic obstructive pulmonary disease and systemic inflammation:asystematie review and a meta-analysis显示文摘 | GAN W Q M A N SF SENTHILSELVAN | 2004 | Thorax2004，59，： | 1 |
| 20 | Cellular basis for the brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segnent elevation显示文摘 | Gan XY Charies A | 1999 | Circ1999，100，15： | 1 |
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