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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | DNA-based immunotherapy: potential for treatment of chronic viral hepatitis显示文摘 | Beckebaum S Cicinnati VR Gerken G | 2002 | Rev Med Virol2002，12，5： | 2 |
| 3 | Clinical significance of autoantibodies to soluble liver antigen in autoimmune hepatitis 显示文摘 | Weidemann C Gerken G | 1999 | J Hepatol1999，31，： | 1 |
| 4 | Turnover rate and kinetic mechanism for the reaction of hydrodechlorination of 1, 1-dichlorotertrafluoroethane(CF3-CFCl2) over a polycrystalling Pd foil显示文摘 | Riberio F H Gerken C A Somorjai G A | 1997 | Catal Lett1997，45，： | 1 |
| 5 | Clinical significance of autoantibodies to soluble liver aneigen in autoimmue hepatitis显示文摘 | Kanzler S Weidemann C Gerken G | 1999 | J Hepatol1999，31，4： | 1 |
| 6 | Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C 显示文摘 | Cario E Gerken G Podolsky D K | 2004 | Gastroenterology2004，127，1： | 1 |
| 7 | Interferon alfa for chronic hepatitis B infection:increased efficacy of prolonged treatment 显示文摘 | JANSSEN H L GERKEN G CARRENO V | 1999 | Hepatology1999，30，2： | 1 |
| 8 | Toll-like receptor 2controls mucosal inflammation by regulating epithelial barrier function 显示文摘 | CARIO E GERKEN G PODOLSKY D K | 2007 | Gastroenterology2007，132，4： | 1 |
| 9 | A tumor necrosis factor- a (TNF-α) promoter polymorphism is associated with chronic hepatitis B infection显示文摘 | Hohler T Kruger A Gerken G | 1998 | Clin Exp Immunol1998，111，3： | 1 |
| 10 | Early HBeAg loss during peginterferon alpha-2b therapy predicts HBsAg loss: results of a long-term follow-up study in chronic hepatitis B patients 显示文摘 | Buster EH Flink I-IJ Simsek H Heathcote FA Sharmila S Kitis GE Gerken G Buti M de Vries RA Verhey E Hansen BE Janssen HL | 2009 | Am J Gastroenterol2009，104，10： | 1 |
| 11 | Patients with type Ⅱ autoimmune hepatitis express functionally intact cytochrome P450 dbl that is inhibited by LKM1 autoantibedies in vitro but not in vivo显示文摘 | Manns M Zanger U Gerken G | 1990 | Hepatology1990，12，： | 1 |
| 12 | HBV viral load within subpopulation of peripheral blood mononuclear cells in HBV infection using limiting dilution PCR 显示文摘 | Trippler M Meyer Z B K H Gerken G | 1999 | J Virol Methods1999，78，12： | 1 |
| 13 | Pre-sencon surface proteins in relation to the majer viral surface antigen in acute hepatitis B virus infection显示文摘 | Gerken G | 1987 | Gastroenterology1987，92，6： | 1 |
| 14 | HLA- DRB1 * 1301 and * 1302 proteet against ehronie hepatitis B显示文摘 | Hohler T Gerken G Notghi A | 1997 | J Hepatol1997，26，3： | 1 |
| 15 | Modern oral cont traceptive use and benign liver tumors:The German benign liver tumor case control study显示文摘 | Helnemann LA Welmann A Gerken G | 1998 | Eur J Contracept Reprod Health Care1998，3，： | 1 |
| 16 | Impact of a self-expanding plastic esophageal stent on various esophageal stenoses,fistulas and leakages:a single-center experience in 39 patients显示文摘 | Radecke K Gerken G Treichel U | 2005 | Gastrointest Endosc2005，61，7： | 1 |
| 17 | Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function显示文摘 | Carlo E Gerken G Podolsky DK | 2007 | Gastroenterology2007，132，4： | 1 |
| 18 | Tumor necrosis factor alpha promoter polymprphism at -238 is associated with chronic active Hepatitis C infection 显示文摘 | Hohlter T Kruger A Gerken G | 1998 | J Med Virol1998，54，3： | 1 |
| 19 | Extracoporeal liver support by fractionated plasma separation and adsorption(Prometheus)in patients with acute-on-chronic liver failure(Helios study):a prospective randomized controlled multicenter study显示文摘 | Rifai K Kribben A Gerken G | | 0，，： | 1 |
| 20 | Mutation specific PCR and direct solid phase sequencing assay for detection of hepatitis B virus pre-c/c mutants in anti-HBe-positive, chronic hepatitis B 显示文摘 | Goergen B Meyer-Zum-Bueschenfeld KH Gerken G | 1994 | J Med Virol1994，43，1： | 1 |
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