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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 显示文摘 | Aoki Y Jaffe ES Chang Y | 1999 | Blood1999，93，12： | 1 |
| 4 | Transdermal delivery of piroxicam using microemulsions显示文摘 | Park ES Cui Y Yun BJ | 2005 | Arch Pharm Res2005，28，2： | 1 |
| 5 | Transient re- ceptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro 显示文摘 | Kim SR Lee da Y Chung ES | 2005 | Neurosci2005，25，3： | 1 |
| 6 | Correlation of calcium measurement with low dose 64-slice CT and angiographic stenosis in patients with suspected coronary artery disease显示文摘 | Ma ES Yang ZG Li Y | 2010 | Int J cardiol2010，140，2： | 1 |
| 7 | Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis 显示文摘 | Hu Y Matsumoto Y Adan ES | 2008 | Ophthalmology2008，115，： | 1 |
| 8 | Serum FGF21 concentration is associated with hypertriglyceridaemia,hyperinsulinaemia and pericardial fat accumulation,independently of obesity,but not with current coronary artery status显示文摘 | Lee Y Lim S Hong ES | 2014 | Clin Endocrinol(Oxf)2014，80，1： | 1 |
| 9 | Tuberculous Addison's disease : mor- phological and quantitative evaluation with muhidetector-row CT 显示文摘 | Ma ES Yang ZG Li Y | 2007 | Eur J Radiol2007，62，： | 1 |
| 10 | VEGF(165)b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy显示文摘 | Varey AHR Rennel ES Qiu Y | 2008 | Br J Cancer2008，98，8： | 1 |
| 11 | An appreciation by a former apprenrice显示文摘 | Flamm ES Professor M Gazi Y | 1999 | Neurosurgery1999，45，5： | 1 |
| 12 | Receptor binding protein amperometric affinity sensor for rapid β-lactam quantification in milk显示文摘 | Setford S J Van Es R M Blandwater Y J | 1999 | Analytica Chimica Acta1999，398，1： | 1 |
| 13 | Dietary calcium,vitamin D and the pre valence of metabolic syndrome in middle-aged and older US women显示文摘 | Liu S Song Y Ford ES | 2005 | Diabetes Care2005，28，： | 1 |
| 14 | Adjuvant chemo- therapy for stage ]] colon cancer with poor prognostic features显示文摘 | O'Gonnor ES Greenblatt D Y Loconte NK | 2011 | J Clin Oncol2011，29，25： | 1 |
| 15 | PPARγ is required for placental,cardiac,andadipose tissue development显示文摘 | Barak Y Nelson MC Ong ES | | 0，，： | 1 |
| 16 | The validity of in vivo tooth volume determinations from cone-beam com- puted tomography显示文摘 | Liu Y Olszewski R Alexandroni ES | 2010 | Angle Orthod2010，80，1： | 1 |
| 17 | Electricity显示文摘 | Gamm A Z Glazunov A Grishin Y A Kolosok IN Korkina ES | 2009 | Development of Algorithms for Estimating the State Electricity System2009，，6： | 1 |
| 18 | Proteomic analysis of potential keratan sulfate,chondroitin sulfate A,and hyaluronic acid molecular interactions显示文摘 | Conrad AH Zhang Y Tasheva ES | | Invest Ophthalmol Vis Sci0，51，9： | 1 |
| 19 | ICAM-1 regulates neutrophll adhesion and transce~ular migration of TNF-alpha-acfivated vascular endothelium under flow显示文摘 | Lin Y Richard MF Tracey ES | 2005 | Blood2005，106，2： | 1 |
| 20 | Dynamically shaped magnetic fields: initial animal validation of a new remote electrophysiology catheter guidance and control system显示文摘 | Gang ES Nguyen BL Shachar Y | 2011 | Circ Arrhythm Electrophysio2011，4，5： | 1 |
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