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| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | 聚乙烯磨损颗粒的大小对人工关节松动的影响显示文摘目的 探讨超高分子聚乙烯磨损颗粒 (UHMWPE)的大小对人工关节松动的影响。方法 从翻修髋关节术所获得组织中提取超高分子聚乙烯磨损颗粒 (平均直径 9.41、5 .96、0 .5 6、0 .3 3 μm ) ,将其与Ceridust 3 615 R○ 颗粒 (模型颗粒 ) (平均直径 14 .2 7、6.3 9、1.74、1.0 1、0 .5 4和 0 .2 8μm)分别刺激人单核 /巨噬细胞 ,并检测培养上清液中的骨溶解介质。 结果 随着UHMWPE颗粒直径的减少 ,其刺激单核 /巨噬细胞分泌白细胞介素 1β ,白细胞介素 6和细胞坏死因子α的作用明显增强 ,而Ceridust 3 615 R○ 颗粒的大小对单核 /巨噬细胞的刺激作用影响不明显。结论 单核 /巨噬细胞对UHMWPE磨损颗粒与Ceridust 3 615 R○ 颗粒的反应明显不同 ,运用模型颗粒研究人工关节松动的机制仍须谨慎。 | 丁悦 Bertram Barden 刘尚礼 黄东生 Franz Ler | 2004 | 中华实验外科杂志2004，21，3： | 17 |
| 3 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 4 | 磨损颗粒刺激巨噬细胞引起人工关节松动的作用机制显示文摘目的探讨来源于人外周血的单核/巨噬细胞对直径1μm以下超高分子聚乙烯(UHMWPE)磨损颗粒的反应及其机制。方法从因无菌性人工髋关节松动而需要行翻修手术的患者假体周围组织中提取UHMWPE磨损颗粒。从10名健康志愿者分别抽取50ml外周血,梯度离心获得外周血中的单核/巨噬细胞。将细胞分为6组:A:单核/巨噬细胞+UHMWPE磨损颗粒;B:单核/巨噬细胞+UHMWPE磨损颗粒+100μMRote-none;C:单核/巨噬细胞+UHMWPE磨损颗粒+10μMU0126;D:单核/巨噬细胞+UHMWPE磨损颗粒+10ng/mlCerivastatin;E:单核/巨噬细胞;F:单核/巨噬细胞+脂多糖(LPS)。检测各组细胞的TNFα表达。结果UHMWPE磨损颗粒明显刺激单核/巨噬细胞分泌TNFα。Rotenone、U0126和Cerivastatin均可抑制UHMWPE磨损颗粒刺激单核/巨噬细胞分泌TNFα,且以U0126明显(P<0.01)。结论UHMWPE磨损颗粒刺激单核/巨噬细胞产生TNFα可通过NF-κB和MAPK通路,但以MAPK通路为主。 | 丁悦 秦础强 马若凡 许杰 刘尚礼 Barden Bertram Ler Franz | 2008 | 中华关节外科杂志(电子版)2008，2，4： | 11 |
| 5 | 中年直立性低血压和晕倒的风险显示文摘每年有1/3老年人晕倒。直立性低血压(orthostatic hypotension,OH)被认为是晕倒的重要危险因素之一,但先前对此研究的结论并不一致。 | Juraschek SP Daya N Appel LJ Miller ER Windham BG Pompeii L Griswold ME Kucharska-Newton A Selvin E 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 3 |
| 6 | Sperling任务中刺激呈现方式对注意分配的影响显示文摘以全部报告法和部分报告法为任务,在Kosslyn瞬时记忆模型框架下,探讨当刺激呈现和报告的方式按列进行时,被试注意窗的放置策略及其对瞬时记忆的影响。结果发现,部分报告优势在这种条件下也是存在的;因为长期的学习而导致的阅读习惯对注意窗放置策略的影响是稳定的;同时发现这种策略使得被试在按列进行的报告方式时,全部报告法和部分报告法的成绩都低于按行报告方式。文章还对上述实验发现作出了进一步的讨论。 | 陈国鹏 王晓丽 方芸秋 Uta Lass Song Yan Dietrich Becker Gerd Lüer | 2004 | 心理科学2004，27，3： | 2 |
| 7 | Microstructure,Properties and Wear Behaviors of (Ni_3Al)_p Reinforced Cu Matrix Composites显示文摘Pure copper and its composites reinforced with Ni 3 Al particles were produced by powder metallurgy(PM).Ni 3 Al powders were produced by mechanical ball milling from vacuum arc melted compounds.The Ni 3 Al powders were characterized by X-ray diffraction(XRD).The microscopy examinations revealed that the Ni 3 Al particles were distributed uniformly in the matrix.The effects of the particle fraction on the density,electrical conductivity,strength and dry sliding wear resistance of composite were investigated.It was found that the density and electrical conductivity of the composites decrease while the compression yield strength and wear resistance of composites increase with an increase in the particle fraction.The dry sliding wear tests were performed with pin-on-disk geometry.After sliding wear tests,the worn surfaces were examined by scanning electron microscopy(SEM) equipped with an energy dispersive X-ray spectrometer(EDS).Results have shown that the wear mechanism is oxidative and adhesive. | Ibrahim elikyrek Nese .Krpe Tugba ler Remzi Grler | 2011 | Journal of Materials Science & Technology2011，27，10： | 2 |
| 8 | Recent innovation in benchmark rates (BMR):evidence from influential factors on Turkish Lira Overnight Reference Interest Rate with machine learning algorithms显示文摘Some countries have announced national benchmark rates,while others have been working on the recent trend in which the London Interbank Offered Rate will be retired at the end of 2021.Considering that Turkey announced the Turkish Lira Overnight Reference Interest Rate(TLREF),this study examines the determinants of TLREF.In this context,three global determinants,five country-level macroeconomic determinants,and the COVID-19 pandemic are considered by using daily data between December 28,2018,and December 31,2020,by performing machine learning algorithms and Ordinary Least Square.The empirical results show that(1)the most significant determinant is the amount of securities bought by Central Banks;(2)country-level macroeconomic factors have a higher impact whereas global factors are less important,and the pandemic does not have a significant effect;(3)Random Forest is the most accurate prediction model.Taking action by considering the study’s findings can help support economic growth by achieving low-level benchmark rates. | Öer Depren Mustafa Tevfik Kartal Serpil KılıçDepren | 2021 | Financial Innovation2021，7，1： | 2 |
| 9 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 10 | 人工髋关节假体旁组织中巨噬细胞亚群的分布显示文摘目的探讨人工髋关节假体周围组织中巨噬细胞亚群的分布情况。方法获取因人工髋关节无菌性松动而行翻修术的37例患者假体周围组织,并用免疫组织化学的方法检测假体周围组织6个区中27E10(+)、25F9(+)和RM3/1(+)巨噬细胞亚群的分布。结果在人工关节假体周围各个区域组织中均有27E10(+)、25F9(+)和RM3/1(+)的巨噬细胞存在。各区中25F9(+)的巨噬细胞百分数分别为(35.12±27.09)%、(42.6±28.01)%、(36.81±23.44)%、(33.86±26.63)%、(42.45±19.12)%和(42.50±29.10)%均高于各区中27E10(+)及RM3/1 (+)巨噬细胞的百分数(P<0.05)。25F9(+)和RM3/1(+)的巨噬细胞亚群在2区、5区和6区较多,1区和4区较少,差异有统计学意义(P<0.05)。结论假体旁组织中巨噬细胞亚群的分布与磨损颗粒相关,假体旁组织中同时存在着急性和慢性炎症过程。巨噬细胞不断地被激活可使炎症不断发展,这也许是导致人工关节假体无菌性松动不可避免的重要原因。 | 丁悦 黄东生 李海刚 刘尚礼 Barden Bertram Ler Franz 马若凡 | 2007 | 中华实验外科杂志2007，24，4： | 2 |
| 11 | Meningiomas infiltrating the superior sagittal sinus:surgical considerations of 328 cases显示文摘 | Caroli E Orlando ER Mastronardi L | 2006 | Neurosurg Rev2006，29，3： | 1 |
| 12 | Smoking,the missing drug interaction in clinical trials:ignoring the obvious显示文摘 | Griz ER Dresler C Sarna L | 2005 | Cancer Epidemiol Biomarkers Prev2005，14，10： | 1 |
| 13 | Systemic administration of Larginine benefits mdx skeletal muscle function显示文摘 | Barton ER Morris L Kawana M | 2005 | Muscle Nerve2005，32，6： | 1 |
| 14 | Prenatal detection of fetal trisomy 18 through abnormal sonographic features 显示文摘 | Yeo L Guzman ER Day-Salvatore D | 2003 | J Ultrasound Meal2003，22，： | 1 |
| 15 | Measuring blood pressure in pregnant won: a comparison of direct and indirect methods显示文摘 | BROWN M A RErI'ER L SMITH B | 1994 | AmJ Ohtet Gynecol1994，171，： | 1 |
| 16 | Meningiomas infiltrating the superior sagittal sinus: surgical considera- tions of 328 cases 显示文摘 | Caroli E Orlando ER Mastronardi L | 2006 | Neurosurg Rev2006，29，3： | 1 |
| 17 | Large-scale rapid oxidation synthesis of SnO, nanoribbons显示文摘 | HUJ Q MA X L SHANG N G er al | 2002 | J Phys Chern B2002，106，15： | 1 |
| 18 | Growth stimulatory angiotensin ]I type - 1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive car- cinoma显示文摘 | DE PAEPE B VERSTRAETEN V L DE POTI'ER C R | 2001 | Histoehem Cell Biol2001，116，3： | 1 |
| 19 | Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice 显示文摘 | Barton-Davis ER Cordier L Shoturma DI | 1999 | J Clin Invest1999，104，4： | 1 |
| 20 | The association of intraoperative factors with the development of postoperative delirium 显示文摘 | Marcantonio ER Golderman L Orav EJ | 1998 | Am J Med1998，105，5： | 1 |
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