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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Extension of life - span by introduction of telomerase into normal cells 显示文摘 | Bodnar AG Ouellette M Frolkis M | 1995 | Science1995，279，5349： | 1 |
| 3 | Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin Ⅱ during myocardial ischernia 显示文摘 | Frolkis I Gurevitch J Yuhas Y | 2001 | Journal of the American College of Cardiology2001，37，1： | 1 |
| 4 | Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia 显示文摘 | Frolkis I Gurevitch J Yuhas Y | 2001 | J Am Coil Cardiol2001，37，1： | 1 |
| 5 | Extension of life-span by introduction of telomerase into normal human cells显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 6 | Extenston of life span by introduction of telomerase into normal human cells 显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，，5439： | 1 |
| 7 | Extension of life- span by introduction of telomerase into normal human cells 显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 8 | Extension of life-span by introduction of telomerase into normal human cells 显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 9 | Extension of life-span by introduction of telomerase into normal human cells 显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 10 | Interaction between paracrine tumor necrosis factor-α and paracrine angiotensin Ⅱ during myocardial ischemia显示文摘 | Inna Frolkis | 2001 | J A Coll Cardiol2001，37，2： | 1 |
| 11 | Extension of life-span by introduction of telomerase into normal human cells 显示文摘 | Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 12 | Extension of life-span by introduction of telomerase into normal human cells 显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 13 | Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia显示文摘 | Frolkis I Gurevitch J Yuhas Y | 2001 | J Am Coil Cardiol2001，37，1： | 1 |
| 14 | Extension of lifespan by introduction of telomerase into normal human cells显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，： | 1 |
| 15 | SMPDB: The Small Molecule Pathway Database 显示文摘 | Frolkis A Knox C Lim E | 2010 | Nucleic Acids Res2010，38，： | 1 |
| 16 | Extension of like-span by introduction of telomerase into normal human cells显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 17 | Extension of life-span by introduction of telomerase into normal human cells显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 18 | Extension of life-span by introduction of telomerase into normal human cells显示文摘 | Ouellette M Frolkis M | 1998 | Science1998，279，： | 1 |
| 19 | Extension of life-span by introduction of telomerase into normal human cells显示文摘 | Bodnar AG Ouellette M Frolkis M | 1998 | Science1998，279，5349： | 1 |
| 20 | Glycerol induced ARF in rats is mediated by tumor necrosis factor-alpha显示文摘 | Shulman LM Yuhas Y Frolkis I | 1993 | Kidney Int1993，43，6： | 1 |
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