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| 1 | 微小RNA-1和微小RNA-29b对急性心肌梗死后不良心室重塑的诊断和预后价值显示文摘已知微小RNA(microRNAs,miRs)在急性心肌梗死(acute myocardial infarction,AMI)临床前期模型中可发挥纤维化和抗纤维化作用。为了评估miR-1,miR-21,miR-29b和miR-92a能否作为患者发生AMI后不良心室重塑(adverse ventricular remodeling,AVR)的循环生物标志物, | 刘莉 叶鹏 Grabmaier U Clauss S Gross L Klier I Franz WM Steinbeck G Wakili R Theiss HD Brenner C | 2017 | 中华高血压杂志2017，25，7： | 17 |
| 2 | 聚乙烯磨损颗粒的大小对人工关节松动的影响显示文摘目的 探讨超高分子聚乙烯磨损颗粒 (UHMWPE)的大小对人工关节松动的影响。方法 从翻修髋关节术所获得组织中提取超高分子聚乙烯磨损颗粒 (平均直径 9.41、5 .96、0 .5 6、0 .3 3 μm ) ,将其与Ceridust 3 615 R○ 颗粒 (模型颗粒 ) (平均直径 14 .2 7、6.3 9、1.74、1.0 1、0 .5 4和 0 .2 8μm)分别刺激人单核 /巨噬细胞 ,并检测培养上清液中的骨溶解介质。 结果 随着UHMWPE颗粒直径的减少 ,其刺激单核 /巨噬细胞分泌白细胞介素 1β ,白细胞介素 6和细胞坏死因子α的作用明显增强 ,而Ceridust 3 615 R○ 颗粒的大小对单核 /巨噬细胞的刺激作用影响不明显。结论 单核 /巨噬细胞对UHMWPE磨损颗粒与Ceridust 3 615 R○ 颗粒的反应明显不同 ,运用模型颗粒研究人工关节松动的机制仍须谨慎。 | 丁悦 Bertram Barden 刘尚礼 黄东生 Franz Ler | 2004 | 中华实验外科杂志2004，21，3： | 17 |
| 3 | 磨损颗粒刺激巨噬细胞引起人工关节松动的作用机制显示文摘目的探讨来源于人外周血的单核/巨噬细胞对直径1μm以下超高分子聚乙烯(UHMWPE)磨损颗粒的反应及其机制。方法从因无菌性人工髋关节松动而需要行翻修手术的患者假体周围组织中提取UHMWPE磨损颗粒。从10名健康志愿者分别抽取50ml外周血,梯度离心获得外周血中的单核/巨噬细胞。将细胞分为6组:A:单核/巨噬细胞+UHMWPE磨损颗粒;B:单核/巨噬细胞+UHMWPE磨损颗粒+100μMRote-none;C:单核/巨噬细胞+UHMWPE磨损颗粒+10μMU0126;D:单核/巨噬细胞+UHMWPE磨损颗粒+10ng/mlCerivastatin;E:单核/巨噬细胞;F:单核/巨噬细胞+脂多糖(LPS)。检测各组细胞的TNFα表达。结果UHMWPE磨损颗粒明显刺激单核/巨噬细胞分泌TNFα。Rotenone、U0126和Cerivastatin均可抑制UHMWPE磨损颗粒刺激单核/巨噬细胞分泌TNFα,且以U0126明显(P<0.01)。结论UHMWPE磨损颗粒刺激单核/巨噬细胞产生TNFα可通过NF-κB和MAPK通路,但以MAPK通路为主。 | 丁悦 秦础强 马若凡 许杰 刘尚礼 Barden Bertram Ler Franz | 2008 | 中华关节外科杂志(电子版)2008，2，4： | 11 |
| 4 | Evolution and advances in laparoscopic ventral and incisional hernia repair显示文摘Primary ventral hernias and ventral incisional hernias have been a challenge for surgeons throughout the ages. In the current era, incisional hernias have increased in prevalence due to the very high number of laparotomies performed in the 20 th century. Even though minimally invasive surgery and hernia repair have evolved rapidly, general surgeons have yet to develop the ideal, standardized method that adequately decreases common postoperative complications, such as wound failure, hernia recurrence and pain. The evolution of laparoscopy and ventral hernia repair will be reviewed, from the rectoscopy of the 4th century to the advent of laparoscopy, from suture repair to the evolution of mesh reinforcement. The nuances of minimally invasive ventral and incisional hernia repair will be summarized, from preoperative considerations to variations in intraoperative practice. New techniques have become increasingly popular, such as primary defect closure, retrorectus mesh placement, and concomitant component separation. The advent of robotics has made some of these repairs more feasible, but only time and well-designed clinical studies will tell if this will be a durable modality for ventral and incisional hernia repair. | Alan L Vorst Christodoulos Kaoutzanis Alfredo M Carbonell Michael G Franz | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 10 |
| 5 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 6 | RATIONAL GENERAL SOLUTIONS OF HIGHER ORDER ALGEBRAIC ODES显示文摘This paper generalizes the method of Ngo and Winkler(2010,2011)for finding rational general solutions of a first order non-autonomous algebraic ordinary differential equation(AODE)to the case of a higher order AODE,provided a proper parametrization of its solution hypersurface.The authors reduce the problem of finding the rational general solution of a higher order AODE to finding the rational general solution of an associated system.The rational general solutions of the original AODE and its associated system are in computable 1-1 correspondence.The authors give necessary and sufficient conditions for the associated system to have a rational solution based on proper reparametrization of invariant algebraic space curves.The authors also relate invariant space curves to first integrals and characterize rationally solvable systems by rational first integrals. | HUANG Yanli NG L X Chu WINKLER Franz | 2013 | Journal of Systems Science & Complexity2013，26，2： | 3 |
| 7 | 人工髋关节假体旁组织中巨噬细胞亚群的分布显示文摘目的探讨人工髋关节假体周围组织中巨噬细胞亚群的分布情况。方法获取因人工髋关节无菌性松动而行翻修术的37例患者假体周围组织,并用免疫组织化学的方法检测假体周围组织6个区中27E10(+)、25F9(+)和RM3/1(+)巨噬细胞亚群的分布。结果在人工关节假体周围各个区域组织中均有27E10(+)、25F9(+)和RM3/1(+)的巨噬细胞存在。各区中25F9(+)的巨噬细胞百分数分别为(35.12±27.09)%、(42.6±28.01)%、(36.81±23.44)%、(33.86±26.63)%、(42.45±19.12)%和(42.50±29.10)%均高于各区中27E10(+)及RM3/1 (+)巨噬细胞的百分数(P<0.05)。25F9(+)和RM3/1(+)的巨噬细胞亚群在2区、5区和6区较多,1区和4区较少,差异有统计学意义(P<0.05)。结论假体旁组织中巨噬细胞亚群的分布与磨损颗粒相关,假体旁组织中同时存在着急性和慢性炎症过程。巨噬细胞不断地被激活可使炎症不断发展,这也许是导致人工关节假体无菌性松动不可避免的重要原因。 | 丁悦 黄东生 李海刚 刘尚礼 Barden Bertram Ler Franz 马若凡 | 2007 | 中华实验外科杂志2007，24，4： | 2 |
| 8 | Electrical remodelling of the human atrium: Similar effects in patients with chronic atrial fibrillation and atrial flutter 显示文摘 | FRANZ M R KARASIK P L LI C | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 9 | Allocating funds for rapair of leaky water distribution systems显示文摘 | Male J W Franz S L | 1986 | TIMS Studies in the ManagementSciences1986，22，3： | 1 |
| 10 | Optical gain in silicon nanocrystals显示文摘 | Pavcsi L Dal Negro L Mazzoleni C Franzò G Priolo F | | 0，，6811： | 1 |
| 11 | Mutation analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2,compared with TSC1,disease in multiple organs显示文摘 | Sergiusz Jozwiak David Neal Franz | 2001 | Am J Hum Genet2001，68，： | 1 |
| 12 | Composition and density model of the continental crust at an active continental margin- The Central Andes between 21° and 27° S 显示文摘 | Lucassen F Becchio R Harmon R Kasemann S Franz G Trumbull R Wilke H-G Romer R L Dulski P | 2001 | Tectono-physics2001，341，14： | 1 |
| 13 | Transient behavior of the strong violet electroluminescence of Ge-implanted SiO2 layers显示文摘 | Rebohle L Gebel T Von Botany J Skorupa W Helm M Pacifici D Franzò G Priolo F | | 0，，： | 1 |
| 14 | Effects of roscovitine on maintenance of the germinal vesicle in horse oocytes, subsequent nuclear maturation,and cleavage rates after intracytoplasmicsperm injection 显示文摘 | Franz L C Choi Y H Squires E L | 2003 | Reprod2003，125，： | 1 |
| 15 | Weak D alleles express distinct phenotypes显示文摘 | Franz F Alexander F Birgit L | 2000 | Blood2000，95，8： | 1 |
| 16 | Surveillance of nosocomial infections in a neurology intensive care unit显示文摘 | Markus Dettenkofer Winfried Ebner Thomas Els Regina Babikir Carl Lücking Klaus Pelz Henning Rüden Franz Daschner | 2001 | Journal of Neurology2001，，11： | 1 |
| 17 | Renin - angiotensin system: a dualtissue and hormonal system for cardiovascular control 显示文摘 | Johnston J I Franz V L | 1992 | JHypertens1992，10，： | 1 |
| 18 | Factor fraction required for the synthesis of bacteriophage Qβ- RNA显示文摘 | Franze de Fernandez MT Eoyang L August JT | 1968 | Nature1968，219，5154： | 1 |
| 19 | Characterisation and selection of probiotic lactobacilli for a preliminary minipig feeding trial and their effects on serum cholesterol levels,faeces pH and faeces moisture content显示文摘 | du TO1T M FRANZ C M A P DICKS L M T | | 0，，： | 1 |
| 20 | Myocardial extracellular K+ and H+ increase and noradrenaline release as possible cause of early arrhythmias following acute coronary artery occlusion in pigs显示文摘 | Hirche H Franz C Bos L | 1980 | J Mol Cell Cardiol1980，12，： | 1 |
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