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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Nanoscale Materials with Mesostructured Interiors显示文摘 | Fowler C E Khushalani D Lebean B | 2001 | Adv Mater2001，13，9： | 1 |
| 3 | Developmental regula tion of low-temperature tolerance in winter wheat显示文摘 | Mahfoozi S Limin A E Fowler D B | 2001 | Annals of Botany2001，87，： | 1 |
| 4 | Nanoscale materials with mesostructured interiors显示文摘 | Fowler C E Khushalani D Lebeau B | 2001 | Adv Mater (Weinheim Ger)2001，13，： | 1 |
| 5 | Interactions among factors regulating phenological development and acclimation rate determine lowtemperature tolerance in wheat显示文摘 | Fowler D B Limin A E | 2004 | Annals of Botany2004，94，5： | 1 |
| 6 | Hyperhomoeysteinemia:an independent risk factor for vascular disease显示文摘 | Daly L Robinson K Nanshten E Cahalane S Fowler B | 1991 | N Engl J Med1991，324，： | 1 |
| 7 | Analysis of temporal noise in CMOS APS显示文摘 | FOWLER B GAMAL A E | 1999 | SPIE1999，3650，： | 1 |
| 8 | The impact of virtual embeddedness on new venture survival: overcoming the liabilities of newness 显示文摘 | MORSE E A FOWLER S W LAWRENCE T B | 2007 | Entreprenuerial Theory and Pratices2007，，3： | 1 |
| 9 | New ventures in the information economy: exploiting virtual embeddedness and knowledge - based assets 显示文摘 | FOWLER S W LAWRENCE T B MORSE E A | 2004 | Academy of Management Best Conference Paper2004，，： | 1 |
| 10 | Relationship between guard cell length and cold hardiness in wheat显示文摘 | Limin A E Fowler D B | 1994 | Can J Plant Sci1994，74，： | 1 |
| 11 | Photoperiod and temperature interactions regulate low - temperature - induced gene expression in barley 显示文摘 | Fowler D B Breton G Limin A E | 2001 | Plant Physiology2001，127，4： | 1 |
| 12 | Compact 810 kA linear transformer driver cavity显示文摘 | Woodworth J R Fowler W E Stoltzfus B S | 2011 | Phys Rev ST Accel Beams2011，14，04： | 1 |
| 13 | Template-directed synthesis of bi-functionalized organo-MCM-41 and phenyl- MCM-48 silica mesophases 显示文摘 | Hall S R Fowler C E Lcbeau B | 1999 | Chemical Communications1999，，2： | 1 |
| 14 | Compact 810 kA linear transformer driver cavity显示文摘 | Woodworth J R Fowler W E Stoltzfus B S | 2011 | Phys Rev Spec Top Accel and Beams2011，14，04： | 1 |
| 15 | Compact810kA linear transformer driver cavity显示文摘 | Woodworth J R Fowler W E Stoltzfus B S | 2011 | Physical ReviewSpecial Topics-Accelerators and Beams2011，14，04： | 1 |
| 16 | Breeding for winter hardiness in cereals显示文摘 | Fowler D B Limin A E | 1997 | Aeta Agronomiea Hungariea1997，45，3： | 1 |
| 17 | Emer- ging therapies for the management of decompensated heart failure: from bench to bedside 显示文摘 | deGoma E M Vagelos R H Fowler M B | 2006 | J Am Coil Cardiol2006，48，12： | 1 |
| 18 | 显示文摘 | CAMPBELL E E B FOWLER P W MITCHELL D | 1996 | Chem Phys Lett1996，250，： | 1 |
| 19 | Analysis of temporal noise in CMOS photodiode active pixel sensor显示文摘 | Tian H Fowler B Gamal A E | 2001 | IEEE Journal of Solid- State Circuits2001，36，1： | 1 |
| 20 | Modeling and estimation of FPN components in CMOS image sensors显示文摘 | Gamal A E Fowler B Min H | 1998 | Proc SPIE1998，3301，： | 1 |
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