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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Robust mult-loop PID controller design-a successive semi-definite programming approach显示文摘 | BAO J FORBES J F MCLELLAN P J | 1999 | Ind Eng Chem Process Des Dev1999，38，： | 2 |
| 3 | Price-driven coordination method for solving plant wide MPC problems显示文摘 | Cheng R Forbes J Yip W | 2007 | Journal of Process Control2007，17，5： | 1 |
| 4 | The specific adsorption of divalent Cd, Co, Cu, Pb and Zn on goethite 显示文摘 | FORBES E A POSNER A M QUIRK J P | 1976 | J Soil Sci1976，27，： | 1 |
| 5 | No contagion, onlyinterdependence; measuring stock market comovements 显示文摘 | FORBES K J RIGOBON R | 2002 | The Journal of Finance2002，57，5： | 1 |
| 6 | The use of early adjuvant aromatase inhibitor therapy: contributions from the BIG 1 -98 letrozole trial 显示文摘 | Forbes J F | 2006 | Semin Oncol2006，33，2： | 1 |
| 7 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 8 | Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease显示文摘 | Burn W C Twigg S M Forbes J M | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 9 | Mitochondrial DNA variation in Indo-Pacific populations of the giant tiger prawn, Penaeus monodon 显示文摘 | Benzie J A H Ballment E Forbes A T | 2002 | Molecular Ecology2002，11，12： | 1 |
| 10 | Advanced g1ycation end-products (AGEs) and functiona-lity of reverse cholesterol transport in patients with type 2 diabetes and in mouse models 显示文摘 | Low H Hoang A Forbes J | 2012 | Diabetologia2012，55，9： | 1 |
| 11 | Model-based real-time optimization of automotive gasoline blending operations显示文摘 | Singh A Forbes J F Vermeer P J | 2000 | Journal of Process Control2000，10，1： | 1 |
| 12 | Laboratory and non-laboratory-based risk prediction models for secondary prevention of cardiovascular disease:the LIPID study显示文摘 | Cui J Forbes A Kirby A | | 0，，06： | 1 |
| 13 | Microsatellite evolution in congeneric mammals:domesticand bighorn sheep显示文摘 | FORBES S H HOGG J T BUCHANAN F C | 1995 | Mol Biol Evul1995，12，6： | 1 |
| 14 | Secretory Ig A:arresting microbial pathogens at epithelial borders显示文摘 | Mantis N J Forbes S J | 2010 | Immunol2010，39，： | 1 |
| 15 | Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects 显示文摘 | CALKIN A C FORBES J M SMITH C M | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 16 | The Wilson disease gene: spectrum of mutations and their consequences 显示文摘 | Thomas G R Forbes J R Roberts E A | 1995 | Nat Genet1995，9，2： | 1 |
| 17 | Model-based real-time optimization of automotive gasoline blending operations 显示文摘 | SINGH J F FORBES P J | 2000 | Journal of Process Control2000，10，1： | 1 |
| 18 | Stitching interferometry: a flexible solution for surface metrology 显示文摘 | Murphy P Forbes G Fleig J | 2003 | Optics and Photonics News2003，14，： | 1 |
| 19 | An evaluation of commu- nity antenatal care显示文摘 | Williams S Dickson D Forbes J | 1989 | Midwifery1989，5，2： | 1 |
| 20 | K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures 显示文摘 | Glicksman M A Forbes M E Pranmer J E | 1995 | J Neurochem1995，64，： | 1 |
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