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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer with special reference to smoking-related end-points upregulation 显示文摘 | DE FLORA S IZZOTTI A D AGOSTINI F | 2001 | Carcinogenesls2001，22，7： | 1 |
| 3 | Numerical Modeling of a Biofilm-electrode Reactor Used for Enhanced Denitrification显示文摘 | Suidan M T Islam S | 1994 | Wat Sci Tech1994，29，1011： | 1 |
| 4 | Hypertension and Sleep Apnea 显示文摘 | Floras J S | 2015 | Can J Cardiol2015，31，7： | 1 |
| 5 | Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells 显示文摘 | De Flora S Micale RT La Maestra S | 2011 | Toxic01 Sci2011，122，1： | 1 |
| 6 | Blood pressure variability: a novel and impor- tant risk faetor显示文摘 | FLORAS J S | 2013 | Can J Cardiol2013，8，4： | 1 |
| 7 | Arsenic and fluoride: two ma- jor ground water pollutants显示文摘 | Chouhan S Flora S J S | 2010 | Indian Journal of Ex- perimental Biology2010，48，： | 1 |
| 8 | Heavy metal induced oxidative stress & its possible reversal by chelation therapy显示文摘 | FLORA S J MFITAL M MEHTA A | 2008 | The Indian J Mocl RES2008，128，4： | 1 |
| 9 | Molecular epidemiology of atherosclerosis显示文摘 | De Flora S Izzotti A Walsh D | 1997 | FASEB J1997，11，： | 1 |
| 10 | Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning显示文摘 | KALIA K FLORA S J | 2005 | j Occup Health2005，47，： | 1 |
| 11 | Heavy metal induced oxidative stress&its possible reversal by chelation therapy显示文摘 | Flora S J S Megha M Ashish M | 2008 | Indian Journal of Medical Research2008，128，4： | 1 |
| 12 | Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA 显示文摘 | Flora S J S Saxena G Gautama P | 2007 | Chem Biol Interact2007，170，3： | 1 |
| 13 | Beneficial effects of δ-adoncsyl-L0methionine on amino levulinic acid dehydratase,gintathione and lipid per oxidation during acute lead-ethanol administration in mice显示文摘 | Flora G J S Seth P K | 1999 | Alcohol1999，18，： | 1 |
| 14 | A survey of preferences and practices of endometrial ablation/resection for menorrhagia in the united显示文摘 | Deb S Flora A Atiomo W | 2008 | Fertil Steril2008，90，5： | 1 |
| 15 | Cancer biomarkers in human atherosclerotic lesions:detection of DNA adducts显示文摘 | Izzotti A De Flora S Petrilli GL | 1995 | Cancer Epidemiol Biol Prev1995，4，： | 1 |
| 16 | Membrance plasmapheresis in the Unitid States: A review over the last 20 Years 显示文摘 | Ghodrat A Siami Flora S | 2001 | Thrapeutic Apheresis2001，5，4： | 1 |
| 17 | Combined administration of taurine and monoisoamyl DMSA protects arsenic induced oxidative injury in rats显示文摘 | Flora SJS Chouhan S Kannan GM | 2008 | Oxid Med Cell Longev2008，1，： | 1 |
| 18 | Mechanism of N-acetyleysteine in the prevention of DNA damage and caner, with special reference to smoking-related end-points 显示文摘 | De Flora S Izzotti A D Agostini F | 2001 | Carcinogenesis2001，22，7： | 1 |
| 19 | Heavy metal induced oxidative stress & its possible reversal by chelation therapy显示文摘 | FLORA S J MITAL M MEHTA A | 2008 | Indian J Med Res2008，128，4： | 1 |
| 20 | Overview of mechanisms of cancer chemopreventive agents 显示文摘 | De Flora S Ferguson L | 2005 | Murat Res2005，591，： | 1 |
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