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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 3 | Cambial-regionspecific expression of the Agrobacterium iaa genes intransgenic aspen visualized by a linked uidA reporter gene 显示文摘 | Tuominen H Regan S Fink S | 2000 | Plant physiology2000，123，2： | 1 |
| 4 | N-Expert A decision support system for vegetable fertilization in the field 显示文摘 | Fink M Scharpf H C | 1993 | Acta Hortic1993，339，： | 1 |
| 5 | Nikolaj Nikolajewitsch Anitschkow established the cholesterol -fed rabbit as a model for atherosclerosis research 显示文摘 | Finking G Hanke H | 1997 | Atherosclerosis1997，135，1： | 1 |
| 6 | Cellulose:Fascinating biopolymer and sustainable raw material显示文摘 | Klemm D Heublein B Fink H P | 2005 | Angew Chem Int Ed2005，44，22： | 1 |
| 7 | The Prevention of Anastomotic Leakage after Total Gastrectomy with Local Decontamination:A Prospective,Randomized,Double-blind,placebo-controlled Multi-center Trial显示文摘 | SCHARDEY H JOOSTEN U FINKE U | 1997 | Ann Surg1997，225，1： | 1 |
| 8 | Digit ratio and hand- grips trength in German and Mizos men; Cross cultural evi- dence f or an organizing effect of prenatal testosteroneons trength 显示文摘 | Fink B Thanzami V Seydel H | 2006 | American Journal of Human Biology2006，18，6： | 1 |
| 9 | Metal oxide/metal pH sensor: effect of anions on pH measurements 显示文摘 | SONG I FINK K PAYER J H | 1998 | Corrosion1998，54，1： | 1 |
| 10 | Preoperative chemotherapy for stage Ⅲ-Ⅳ gastric carcinoma: feasibility, response and outcome after complete resection显示文摘 | Fink U Schuhmacher Stein H J | 1995 | Br J Surg1995，82，： | 1 |
| 11 | New developments in the treatment of gastric carcinoma显示文摘 | Wike H Preusser P Fink U | 1990 | Semin Oncol1990，17，1： | 1 |
| 12 | Structural aspects of new cellulose fibres and films from NMMO-solution显示文摘 | H P Fink P Weigel H J Purz | 1998 | Polymer Science1998，2，： | 1 |
| 13 | 显示文摘 | Heuer A H Fink D J Laraia V J | 1992 | Science1992，2552，： | 1 |
| 14 | Hypercalcemic-type of small cell carcinoma of the ovary: characterization of a new tumor line 显示文摘 | Walt H Homung R Fink D | 2001 | Anticancer Res2001，21，5： | 1 |
| 15 | From generic restoration actions to specific restoration strategies显示文摘 | Fink L H Liou Kan-Lee Liu Chen-Ching | | 0，，02： | 1 |
| 16 | Cellulose: FascinatingBiopolymer and Sustainable Raw Material 显示文摘 | Kleram D Heublein B Fink H P | 2005 | Angewandte Chernie-1nlemutumal Edition2005，44，22： | 1 |
| 17 | Using uhrasonog- raphy to determine thyroid size and prevalence of goiter in lithium-treated patients with affective disorders显示文摘 | Bauer M Blumentritt H Finke R | 2007 | J Affect Disord2007，104，13： | 1 |
| 18 | Metal oxide metal pH sensor: Effect of anions on pH measurements显示文摘 | Song I Fink K Payer J H | 1998 | Corrosion1998，54，1： | 1 |
| 19 | Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats显示文摘 | Xu H Fink GD Chen A | | 0，，2： | 1 |
| 20 | Muscle relaxant use for tracheal intubation in pediatric anaesthesia:a survey of clinical practice in Germany显示文摘 | Nauheimer D Fink H Fuchs-Buder T | | 0，，3： | 1 |
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