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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Transepithelial taurine transport in Caco-2 cell monolayers显示文摘 | ROIG-PóREZ S MORETó M FERRER R | 2005 | Journal of Membrane Biology2005，204，： | 1 |
| 3 | Deteetion and identification of species of the genus Fabavirus by RT- PCR with a single pair of primers显示文摘 | Ferrer R M Luis Arteaga M Guerri J | 2007 | Journal Of VirologicalMethods2007，144，： | 1 |
| 4 | Mucosal surface area in chicken small intestine during development显示文摘 | Mitjans M Bamiol G Ferrer R | 1997 | Cell and Tissue Research1997，290，1： | 1 |
| 5 | Prion protei expresion in senile plaques in Alzheimer' s disease 显示文摘 | Ferrer I Blanco R Carmona M Pnig B Ribera R Rey M J | 2001 | Acta Neuropatho12001，101，1： | 1 |
| 6 | Genetic and physiologic dissection of the vertebrate cardiac conduction system显示文摘 | Chi N C Shaw R M Jungblut B Huisken J Ferrer T Arnaout R | 2008 | PLoS Biol2008，6，： | 1 |
| 7 | Inversion of stereospecificity of vanillyl-alcohol oxidase显示文摘 | van den Heuvel R H Fraaije M W Ferrer M | 2000 | Proc Natl Acad Sci U S A2000，97，17： | 1 |
| 8 | Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P) , stress-activated protein kinase ( SAPK/JNK-P ), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies 显示文摘 | Ferrer I Blanco R Carmona M | 2001 | J Neural Transm2001，108，12： | 1 |
| 9 | Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat 显示文摘 | Ferrer I Olivé M Blanco R | 1996 | Molecular Brain Research1996，38，： | 1 |
| 10 | Automatic control of tracheal tube cuff pressure in ventilated patients in semirecambent position:a randomized trial显示文摘 | Valencia M Ferrer M Farre R | 2007 | Critical Care Medicine2007，35，6： | 1 |
| 11 | The Impact of aquality improvement intervention to reduce nosocomialinfections in a PICU 显示文摘 | Esteban E Ferrer R Urrea M | 2013 | Pediatric Critical Care Med2013，14，5： | 1 |
| 12 | Dissection of malonyl-coenzyme a decarboxylation from polyketide for marion in the reaction mechanism of a plant polyketide synthase显示文摘 | JEZ J M FERRER J L BOWMAN M E DIXON R A NOEL J P | 2000 | Biochemistry2000，39，5： | 1 |
| 13 | A population of CRES resides in the outer dense fibers of spermatozoa显示文摘 | FERRER M CORNWALL G OKO R | 2013 | Biology of Reproduction2013，88，3： | 1 |
| 14 | Diagnosis ofParietaria judaica pollan allergy using natural and recom-binant Par jl and Par j2 allei^ens 显示文摘 | Gonzdlez-Rioja R Ferrer A Arilla M C | 2007 | Clin Exp Allergy2007，37，2： | 1 |
| 15 | Determination of sulfonated azo dyes in river water samples by capillary zone electrophoresis显示文摘 | -M Ferrer -R | 2000 | J-Chromatogr -A2000，883，12： | 1 |
| 16 | Intensive care adult patients with severe respiratory failure caused by influenza A(H1N1)v in Spain显示文摘 | Rello J Rodríguez A Ibaez P Socias L Cebrian J Marques A Guerrero J Ruiz-Santana S Marquez E Del Nogal-Saez F Alvarez-Lerma F Martínez S Ferrer M Avellanas M Granada R Maraví-Poma E Albert P SierraR Vidaur L Ortiz P Prieto del Portillo I Galván B León-Gil C H1N1SEMICYUC Working Group | 2009 | Crit Care2009，13，5： | 1 |
| 17 | Impact of BAL on the diagnosis and treatment of nosocomial pneumonia in ICU pa- tients显示文摘 | FERRER R IOANAS M AGUSTI C | 2001 | Monaldi Arch Chest Dis2001，56，6： | 1 |
| 18 | Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma显示文摘 | Ferrer P Asensi M Segarra R | 2005 | Neoplasia2005，7，1： | 1 |
| 19 | An economic assessment of proteins recovery from fish meal effluents by ultrafihration显示文摘 | Afonso M D Ferrer J Borquez R | 2004 | Trends in Food Science & Technology2004，1015，10： | 1 |
| 20 | Prion protein expresion in senile plaques in Alzheimer' s disease 显示文摘 | Ferrer I Blanco R Carmona M Puig B Ribera R Rey M J | 2001 | Acta Nenropatho12001，101，： | 1 |
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