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| 1 | Characterization and of Ralstonia TAL-Like DNA-Binding Specificities Effectors显示文摘从 Xanthomonas sp 的抄写像使活跃之物的受动器(故事) 。为染色体工程应用被用作可定制的 DNA 有约束力的模块。Ralstonia solanacearum 像故事的蛋白质(RTL ) 展出类似的结构的特征到故事,包括一个中央 DNA 有约束力的领域填写了 of35 氨基的酸长的重复。这里,我们描绘他们作为 transcriptional 使活跃之物在植物房间原子核, mediateDNA 绑定,和力量功能本地化的 RTL 和表演。RTL 有唯一的 DNA 有约束力的体系结构并且是 enrichedin 重复变量 di 残余(RVD ) ,它决定重复 DNA 有约束力的特性。我们决定了 DNA 有约束力的 specificitiesfor RVD 序列 ND, HN, NP,和 NT。RVD ND 调停和 C 核苷酸的高度特定的相互作用, HN interactsspecifically 与 A 和 G 核苷酸,和 NP 绑在 C, A,和 G 核苷酸。而且,我们发展了一高度为设计 RTL 受动器的 efficientrepeat 集会途径。一起拿,我们的数据证明 RTL 是是要定制为指向的 genomic 和 epigenomicmodifications 绑在选择用户的 DNA 序列的优秀选择的唯一的 DNA-targetingmodules。这些调查结果将在 pathogenicityof Ralstonia spp.Key 词有关 RTL 分子的生物学和 RTL 角色便于研究: | Lixin Li Ahmed Atef Agnieszka Piatek Zahir Ali Marek Piatek Mustapha Aouida Altanbadralt Sharakuu Ali Mahjoub Guangchao Wang Suhail Khan Nina V. Fedoroff Jian-Kang Zhu Magdy M. Mahfouz | 2013 | Molecular Plant2013，6，4： | 3 |
| 2 | Expression of stem cell factor and C-kit receptor in neural cells after brain injury显示文摘 | Zhang SC Fedoroff S | 1999 | Acta Neuropathol (Berl)1999，97，： | 1 |
| 3 | Microglia and astroglia have a common progenitor cell显示文摘 | Fedoroff S Zhai R Novak JP | 1997 | J Neurosci Res1997，50，3： | 1 |
| 4 | The Arabidopsis doublestranded RNA-binding protein HYL1 plays a role in microRNAmediated gene regulation显示文摘 | Han M H Goud S Song L Fedoroff N | 2004 | Proc Natl Acad Sci USA2004，101，4： | 1 |
| 5 | Climate extremes in Loess of China coupled with the strength of deep-water formation in the North Atlantic显示文摘 | Guo Z T Liu T S Fedoroff N | 1998 | Global and Planetary Change1998，18，： | 1 |
| 6 | Generalized anxiety disorder after stroke显示文摘 | Castillo CS Starkstein SE Fedoroff JP | 1993 | J Nerv Ment Dis1993，181，： | 1 |
| 7 | Macrophage-like cells originate from neuroepithelium in culture:characterization and properties of the macrophage-like cells显示文摘 | Hao C Richardson A Fedoroff S | 1991 | Int J Dev Neurosci1991，9，1： | 1 |
| 8 | LRP1,a gene expressed in lateral and adventitious root primordia of Arabidopsis显示文摘 | Smith D L Fedoroff N V | 1995 | The Plant Cell Online1995，7，6： | 1 |
| 9 | NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA显示文摘 | Fedoroff OY Salazar M Han H | 1998 | Biochemistry1998，37，12： | 1 |
| 10 | Improving Asia-Pacific science collaboration显示文摘 | Toope S J Tan C C Fedoroff N V | 2012 | Science2012，336，6077： | 1 |
| 11 | Macrophage-like cells originate from neuroepithelium in culture:characterization and properies of the macrophage-like cells显示文摘 | Hao C Richardson A Fedoroff S | 1991 | Int J Dev Neurisci1991，9，1： | 1 |
| 12 | Molecular Identification and Iso- lation of the waxy lxcus in Maize显示文摘 | Shure M Wessler S Fedoroff N V | 1983 | Cell1983，35，： | 1 |
| 13 | Climate extremes in Loess of China coupled with the strength of deep-water formation in the North Atlantic显示文摘 | Guo Z T Liu T S Fedoroff N | 1998 | Global and Planetary Change1998，18，： | 1 |
| 14 | A mutation in the Arabidopsis HYL1 gene encoding a dsRNA binding protein affects responses to abscisic acid ,auxin,and cytokinin显示文摘 | CHENG LU NINA FEDOROFF | 2000 | The Plant Cell2000，12，： | 1 |
| 15 | Radically rethinking agriculture for the 21st century 显示文摘 | Fedoroff N V Battisti D S Beaehy R N | 2010 | Science2010，327，： | 1 |
| 16 | Sorption of selenium anionic species on apatites and iron oxides from aqueous solutions显示文摘 | Duc M Lefevre G Fedoroff M | 2003 | Journal of Environmental Radioactivity2003，，70： | 1 |
| 17 | Climate extremes in Loess of China coupled with the strength of deep-water formation in the North Atlantie显示文摘 | Guo Z Liu T Fedoroff N | 1998 | Global and Planetary Change1998，18，： | 1 |
| 18 | Radically rethinking agriculture for the 21st century显示文摘 | N V Fedoroff D S Battisti R N Beachy | 2010 | Science2010，327，5967： | 1 |
| 19 | Climate Extremes in Loess of China Coupled with the Strength of Deep - water Formation in the North Atlantic显示文摘 | Guo Z Liu T Fedoroff N | 1998 | Global and Planetary Change1998，18，： | 1 |
| 20 | Climate extremes in Loess of China coupled with the strength of deep-water formation in the North Atlantic显示文摘 | Guo Z T Liu T S Fedoroff N | 1998 | Global and Planetary Change1998，18，34： | 1 |
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