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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Microstructure and oxygen storage capacity of Sr-modified Pt/CeO_2-ZrO_2 catalysts | Rui Ran a,Jun Fan b,Duan Weng a,a State Key Lab of New Ceramic and Fine Processing,Department of Materials Science and Engineering,Tsinghua University,Beijing 100084,China b The Administrative Centre for China’s Agenda 21,Beijing 100038,China | 2012 | Progress in Natural Science:Materials International2012，22，1： | 5 |
| 3 | Hepatology|过氧化物酶体增殖物激活受体α通过YAP-TEAD信号通路促进肝脏增大和肝脏再生显示文摘过氧化物酶体增殖物激活受体α(PPARα)是内/外源物质代谢调控的关键核受体之一。Yes相关蛋白(YAP)是Hippo信号通路的核心调节元件,YAP激活后入核与转录因子TEAD结合,启动下游基因表达,对肝脏大小起到重要调控作用。PPARα激动可致肝增大并在肝再生过程中发挥关键作用,但具体机制仍不清楚。该研究旨在揭示PPARα通过YAP-TEAD信号通路促进肝增大和肝再生的分子调节机制。 | 毕惠嫦 范仕成 高悦 FAN S GAO Y QU A | 2022 | 临床肝胆病杂志2022，38，2： | 2 |
| 4 | A framework for integrated quality system显示文摘 | HEREDIA J A FAN I S | 1996 | Journal of Materials Processing Technology1996，61，12： | 1 |
| 5 | Novel Sensitive high-throughput screening strategy for nitrilase-producing strains 显示文摘 | Zhu Q Fan A Wang Y S | 2007 | Applied and Enviromental Microbiology2007，73，19： | 1 |
| 6 | Regime diagrams and characteristics of flame patterns in radial microchannels with temperature gradients显示文摘 | Fan A W Minaev S Kumar S | | 0，，03： | 1 |
| 7 | Fault-tree analysis by fuzzy probability 显示文摘 | TANNK A H FAN L T LAI F S | 1983 | IEEE Transactions on Reliability1983，32，5： | 1 |
| 8 | Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock显示文摘 | Rizoli S B Kspus A Fan J | 1998 | J Immunol1998，161，： | 1 |
| 9 | A singular integral operator related to block spaces显示文摘 | Al-HASAN A J FAN D S | 1999 | Hokkaido Math J1999，28，： | 1 |
| 10 | Chronic kidney dis- ease and the risks of death, cardiovascular events, and hospi- talization显示文摘 | GO A S CHERTOW G M FAN D | 2004 | N Engl J Med2004，351，13： | 1 |
| 11 | Experimental study on flame pattern formation and combustion completeness in a radial microchannel显示文摘 | Fan A W Minaev S Kumar S | | 0，，12： | 1 |
| 12 | Dispersion and packing of carbon nanotubes显示文摘 | SHAFFER M S P FAN X WINDLE A H | 1998 | Carbon1998，36，： | 1 |
| 13 | ATF3 induction following DNA damage is regulated by distinct signaling pathways and overexpression of ATF3 protein suppresses cells growth 显示文摘 | Fan F Jin S Amundson S A | 2002 | Oncogene2002，21，49： | 1 |
| 14 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 15 | Experimental and numerical investigations of flame pattern formation in a radial microchannel显示文摘 | Fan A W Minaev S Sereshchenko E V | | 0，，02： | 1 |
| 16 | An experimental investigation on fatigue crack growth of AL6XN stainless steel显示文摘 | Kalnaus S Fan F Vasudevan A K Jiang Y | 2008 | Engineering Fracture Mechanics2008，75，： | 1 |
| 17 | Petrogenesis of post-orogenic syenites in the Sulu Orogenic Belt, East China: geochronological, geochemical and Nd-Sr isotopic evidence 显示文摘 | Yang Jin-hui Chung Sun-lin Wilde S A Wu Fu-yuan Chu Mei-fei Lo Ching-hua Fan Hong-rui | 2005 | Chemical Geology2005，214，12： | 1 |
| 18 | Effect of fibrous orientation on dynamic mechanical properties and susceptibility to adiabatic shear band of tungsten heavy alloy fabricated through hot-hydrostatic extrusion显示文摘 | Liu J Li S Fan A | 2008 | Materials Science and Engineering:A2008，487，1： | 1 |
| 19 | 2011, Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humans 显示文摘 | Zhu H Zhou B Fan X Lam T T Wang J Chen A Chen X Chen H Webster R G Webby R Peiris J S Smith D K Guan Y | 2011 | Journal of Virology2011，85，10： | 1 |
| 20 | Butorphanol: effect s of a prototypical agonist-antagonist analgesic on kappa-opioid receptors显示文摘 | Commiskey S Fan LW Ho IK et a l | 2005 | J Pharmacol Sci2005，98，： | 1 |
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