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| 1 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 2 | The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk显示文摘 | Hou SM Falt S Angelini S | 2002 | Carcinogenesis2002，23，4： | 1 |
| 3 | Swelling of model films of cellulose having different charge densities and comparison to the Swelling behavior of corresponding fibers 显示文摘 | Susanna Falt | 2003 | Langmuir2003，19，： | 1 |
| 4 | The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk显示文摘 | Hou SM Falt S Angelini S | 2002 | Carcinogenesis2002，23，： | 1 |
| 5 | The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk显示文摘 | Hou SM Falt S Angelini S | 2002 | Carcinogenesis2002，23，4： | 1 |
| 6 | The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk显示文摘 | Hou S M Falt S Angelini S | 2002 | Carcinogenesis2002，23，4： | 1 |
| 7 | Prostacyclin is produced from endothelial cell-seeded grafts:an experimental study in sheep显示文摘 | JENSEN N BRUNKWALL J FALT | 1992 | Eur J Vasc Surg1992，6，5： | 1 |
| 8 | What students really learn: contrasting medical and nursing students' experiences of the clinical learning environment显示文摘 | Libedahl M Boman L E Falt C P | 2014 | Adv Health Sci Educ Theory Pract2014，，： | 1 |
| 9 | Identification and functional screening of mieroRNAs highly deregulated in eolorectal eancer显示文摘 | FALT SVOBODA M SRUTOVA K | 2012 | Journal of Cellular and Molecular Medicine2012，16，11： | 1 |
| 10 | Introduction: Special Issue on Distributed Constraint Satisfaction 显示文摘 | Faltings B Yokoo M | 2005 | Artificial Intelligence2005，161，： | 1 |
| 11 | GSTM1 and NAT2 polymorphisms in operable and non-operable lung cancer patients显示文摘 | Hou S M Ryberg D Falt S | 2000 | Carcinogenesis2000，21，1： | 1 |
| 12 | Open Constraint Programming 显示文摘 | Faltings B Gonzalez S M | 2005 | Artificial Intelligence2005，161，： | 1 |
| 13 | Model films of cellulose Ⅱ-Improved preparation method and characterization of the cellulose firm显示文摘 | Falt S Wagberg L Vesterlind E-L | 2004 | Cellulose2004，11，： | 1 |
| 14 | Introduction: Configuration 显示文摘 | Faltings B Freuder E C | 1998 | IEEE Intelligent Systems1998，13，4： | 1 |
| 15 | The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk显示文摘 | Hou SM Falt S Angelini S | 2002 | Carcinogenesis2002，23，4： | 1 |
| 16 | GSTM1 and NAT2 polymorphisms in operable and non- operable lung cancer patients显示文摘 | Hou SM Ryberg D Falt S | 2000 | Carcinogenesis2000，21，1： | 1 |
| 17 | Asynchronous aggregation and consistency in distributed constraint satisfaction显示文摘 | Silaghi M C Faltings B | 2005 | Artificial Intelligence2005，161，12： | 1 |
| 18 | The rapid detection of low molecular mass proteins differentially expresed under biological stress for four Helicobacter spp using protein chip technology 显示文摘 | Hynes SO McGuire J Falt T | 2003 | Proteomics2003，3，3： | 1 |
| 19 | Constraint-based support for collaboration in design and construction显示文摘 | Lottaz C Clement D E Faltings B V | 1999 | J Comput Civ Eng1999，13，1： | 1 |
| 20 | Model films of cellulose: Ⅱ - improved preparation method and characterization of the cellulose film显示文摘 | FALT S WAGBERG L VESTERLIND E L | 2004 | Cellulose2004，11，： | 1 |
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