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| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Diagnosing Cultural Barriers to Knowledge Management 显示文摘 | De Long D W Fahey L | 2000 | The Academy of Management Executive2000，14，4： | 1 |
| 3 | ln viw~ visualization of abdominal malignancies with acoustic radiation three elastograph显示文摘 | Fahey R J Nelson R C Bradway D P el al | 2008 | Phys MedBiol2008，53，1： | 1 |
| 4 | Nutritional support of the cancer patient显示文摘 | Rivadeneira DE Evoy D Fahey TJ | 1998 | Cancer JClin1998，，48： | 1 |
| 5 | Interferon-beta enhances the synthesis of a 20,000 dalton membrane protein:A correlation with the cessation of cell growth显示文摘 | KNIGHT EJ FAHEY D BLOMSTROM DC | 1985 | J Inter feron Res1985，5，2： | 1 |
| 6 | Bounding the role of black carbon in the climate system: A scientific assessment 显示文摘 | BOND T C DOHERTY S J FAHEY D W | 2013 | Journal of Geophysical Research : Atmospheres2013，118，11： | 1 |
| 7 | In vitro fermentation of cellulose, beet pulp, citrus pulp and citrus pectin u sing fecal inoculum from cats, dogs, horses, humans, and pigs and ruminal fluid from cattle显示文摘 | Sunvold G D Hussein H S Fahey G C | 1995 | Journal of Animal Science1995，73，： | 1 |
| 8 | Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to imlhiocya- nares by the gastrointestinal microflora显示文摘 | Fahey J W Wehage S L Holtzclaw W D | 2012 | Cancer Prevention Researcb2012，，5： | 1 |
| 9 | Diagnosing Cultural Banners to Knowledge Management 显示文摘 | DELONG D W FAHEY | 2000 | Academy of Management Executive ( 14: 4)2000，，： | 1 |
| 10 | Forest road erosion in New Zealand: overview显示文摘 | Fransen P J B C J Phillips B D Fahey | 2001 | Earth Surface Processes and Land-forms2001，26，： | 1 |
| 11 | Bounding the role of black carbon in the climate system: A scientific assessment显示文摘 | Bond T C Doherty S J Fahey D W | 2013 | Journal of Geophysical Research-Atmosphere2013，118，： | 1 |
| 12 | Soil nitrogen availability affects belowground carbon allocation and soil respiration in northern hardwood forests of New Hampshire显示文摘 | BAE K FAHEY T J YANAI R D | 2015 | Ecosystems2015，18，： | 1 |
| 13 | Diagnosing Cultural Barriers to Knowledge Management显示文摘 | FAHEY L | 2000 | The Academy of Management Executive2000，，14： | 1 |
| 14 | Human Papillomavirus can escape immune recognition through Langerhans call phosphoinositide 3-kinase activation 显示文摘 | Fausch S C Fahey L M Da Silva D M | 2005 | J Imm2005，174，11： | 1 |
| 15 | Immunonutrition:the role of arginine显示文摘 | Evoy D Lieberman M D Fahey T J | 1998 | Nutrition1998，14，7： | 1 |
| 16 | Diagnosing cultural barriers to knowledge management显示文摘 | De Long D W Fahey L | 2002 | The Academy of Management Executive2002，14，04： | 1 |
| 17 | Effect of calcium salts of fatty acids and calcium salt of methionine hydroxy analogue on reproductive responses and milk production in Holstein-Friesian cows 显示文摘 | Fahey J Mee J F CaUaghan O D | 2002 | J Anim Sci2002，74，： | 1 |
| 18 | Fermentation of various dietary fibre sources by human fecal bacteria显示文摘 | Bourquin L D Titgemeyer E C Fahey G C | 1996 | Journal of Nutrition Research1996，16，7： | 1 |
| 19 | Distribution of halon-1211 in the upper troposphere and lower stratosphere and the 1994 total bromine budget 显示文摘 | Wamsley P R Elkins J W Fahey D W | 1998 | Journal of Geophysical Re- search1998，103，： | 1 |
| 20 | Postharvest treatment of fibrous feedstuffs to improve their nutritive value显示文摘 | Fahey G Bourquin L Titgemeyer E Atwell D | 1993 | Forage cell wall structure and digestibility1993，，： | 1 |
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