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您的检索式：作者名="Fabrício Freirede Melo"
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| 1 | Relationship between Mollicutes and spontaneous abortion:An epidemiological analysis显示文摘BACKGROUND Abortion is of great importance in public health,as it is among the main causes of maternal morbidity and mortality.In addition to sociodemographic-and lifestylerelated factors,studies have associated infections of the genital tract with higher rates of abortion.Therefore,the exacerbated presence and rise of Mollicutes in the genitourinary tract may be related to higher rates of abortion.AIM To perform an epidemiological analysis of women who had spontaneous abortions and placental colonization by Mollicutes in a maternity hospital.METHODS This cross-sectional study involved the collection of data and biological material from women hospitalized due to spontaneous abortion or term delivery.The sample consisted of 89 women who miscarried and 20 women who had full term pregnancy.Data collection was carried out in three stages:(1)Conducting research on the information and clinical data in medical records of patients hospitalized due to abortion;(2)Application of a semi-structured questionnaire to identify the patient's epidemiological profile and(3)Collection of placental tissue.Placental samples were collected after the curettage procedure(abortion)and after placental expulsion(delivery),both performed by an obstetrician.Microbial identification in the fragments was performed by real-time polymerase chain reaction.In this study,the following explanatory variables were considered:(1)Sociodemographic variables;(2)Variables related to access to health services;(3)Variables related to lifestyle;and(4)Variables related to sexual and reproductive health,all of which were used to perform descriptive,univariate and multivariate analyses.RESULTS In the final model,placental colonization by Mollicutes was independently associated with the variables age[odds ratio(OR)=7.55;CI:2.37-24.03]and menarche(OR=3.43;CI:1.03-11.44).In this investigation,the prevalence of Mollicutes colonization by at least one of the following three species:Mycoplasma hominis,Ureaplasma urealyticum,Ureaplasma parvum in women who had spontaneous abortion was 73.0%.When comparing colonization between the two groups of participating women,there was an 8.12-fold risk of placental colonization by at least one Mollicutes species in the women who had an abortion,compared to those who completed pregnancy.The final multivariate analysis model revealed a statistically significant association between placental colonization by Mollicutes in abortion with the following variables:age,as women up to 29 years old had a 7.55-fold risk of spontaneous abortion,compared to those who were older than 29 years;menarche,where women who had menarche up to 13 years old had a 3.43-fold risk of miscarriage compared to those who had menarche over 13 years old;and a change in eating habits,after the discovery of pregnancy,was a protective factor(OR=0.16).CONCLUSION These findings revealed a positive association between spontaneous abortion and placental colonization by Mollicutes.This indicates the need for further investigation of this issue,to guide decision-making for the prevention of abortion. | Maria Tânia Silva Oliveira Caline Novais Teixeira Oliveira Lucas Santana Coelho da Silva Hellen Braga Martins Oliveira Raquel Sousa Freire Lucas Miranda Marques Maria Luísa Cordeiro Santos Fabrício Freirede Melo Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2021 | World Journal of Obstetrics and Gynecology2021，10，1： | 0 |
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