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| 1 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 2 | Biliary drainage strategy of unresectable malignant hilar strictures by computed tomography volumetry显示文摘AIM:To identify criteria for predicting successful drainage of unresectable malignant hilar biliary strictures(UMHBS) because no ideal strategy currently exists.METHODS:We examined 78 patients with UMHBS who underwent biliary drainage.Drainage was considered effective when the serum bilirubin level decreased by ≥ 50% from the value before stent placement within 2 wk after drainage, without additional intervention.Complications that occurred within 7 d after stent placement were considered as early complications.Before drainage, the liver volume of each section(lateral and medial sections of the left liver and anterior and posterior sections of the right liver) was measured using computed tomography(CT) volumetry.Drained liver volume was calculated based on the volume of each liver section and the type of bile duct stricture(according to the Bismuth classification).Tumor volume, which was calculated by using CT volumetry, was excluded from the volume of each section.Receiver operating characteristic(ROC) analysis was performed to identify the optimal cutoff values for drained liver volume.In addition, factors associated with the effectiveness of drainage and early complications were evaluated.RESULTS:Multivariate analysis showed that drained liver volume [odds ratio(OR) = 2.92, 95%CI:1.648-5.197; P < 0.001] and impaired liver function(with decompensated liver cirrhosis)(OR = 0.06, 95%CI:0.009-0.426; P = 0.005) were independent factors contributing to the effectiveness of drainage.ROC analysis for effective drainage showed cutoff values of 33% of liver volume for patients with preserved liver function(with normal liver or compensated livercirrhosis)and 50%for patients with impaired liver function(with decompensated liver cirrhosis).The sensitivity and specificity of these cutoff values were82%and 80%for preserved liver function,and 100%and 67%for impaired liver function,respectively.Among patients who met these criteria,the rate of effective drainage among those with preserved liver function and impaired liver function was 90%and 80%,respectively.The rates of effective drainage in both groups were significantly higher than in those who did not fulfill these criteria(P<0.001 and P=0.02,respectively).Drainage-associated cholangitis occurred in 9 patients(12%).A smaller drained liver volume was associated with drainage-associated cholangitis(P<0.01).CONCLUSION:Liver volume drainage≥33%in patients with preserved liver function and≥50%in patients with impaired liver function correlates with effective biliary drainage in UMHBS. | Ei Takahashi Mitsuharu Fukasawa Tadashi Sato Shinichi Takano Makoto Kadokura Hiroko Shindo Yudai Yokota Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 3 | Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP) in patients with surgically altered anatomy has been a major challenge to gastrointestinal endoscopists with low success rates for reaching the target site as well as high complication rates. The knowledge of ERCP-related risk factors is important for reducing unexpected complications.AIM To identify ERCP-related risk factors for perforation in patients with surgically altered anatomy.METHODS The medical records of 187 patients with surgically altered anatomy who underwent ERCP at our institution between April 2009 and December 2017 were retrospectively reviewed. An analysis of patient data, including age, sex, type of reconstruction, cause of surgery, aim of ERCP, success rate of reaching target site,success rate of procedure, adverse events, type of scope, time to reach the target site, and duration of procedure, was performed. In patients with Billroth-Ⅱ reconstruction, additional potential risk factors were the shape of the inserted scope and whether the anastomosis was antecolic or retrocolic.RESULTS All patients(n = 187) had surgical anatomy, such as Billroth-Ⅰ(n = 22), Billroth-Ⅱ(n = 33), Roux-en-Y(n = 54), Child, or Whipple reconstruction(n = 75). ERCP was performed for biliary drainage in 43 cases(23%), stone removal in 29 cases(16%),and stricture dilation of anastomosis in 59 cases(32%). The scope was unable to reach the target site in 17 cases(9%), and an aimed procedure could not be accomplished in 54 cases(29%). Adverse events were pancreatitis(3%),hyperamylasemia(10%), cholangitis(6%), cholestasis(4%), excessive sedation(1%), perforation(2%), and others(3%). Perforation occurred in three cases, all of which were in patients with Billroth-Ⅱ reconstruction; in these patients, further analysis revealed loop-shaped insertion of the scope to be a significant risk for perforation(P = 0.01).CONCLUSION Risk factors for perforation during ERCP in patients with surgically altered anatomy were Billroth-Ⅱ reconstruction and looping of the scope during BillrothⅡ procedure. | Shinichi Takano Mitsuharu Fukasawa Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi Hayakawa Hiroshi Yokomichi Makoto Kadokura Tadashi Sato Nobuyuki Enomoto | 2019 | World Journal of Clinical Cases2019，7，1： | 6 |
| 4 | A survey on energy consumption in rural households in the fringes of Xian city显示文摘 | Yutaka Tonooka Jiaping Liu Yasuhiko Kondou Yadong Ning Oki Fukasawa | 2006 | Energy & Buildings2006，，11： | 2 |
| 5 | 冷冻-干燥工艺合成复合孔结构的多孔陶瓷显示文摘冷冻-干燥工艺合成了复合孔结构的多孔陶瓷。控制冰的生长方向的同时完成水基陶瓷浆料的冻结。在低压下干燥使冰由固态到气态而升华。烧成后的坯体为具有复合孔结构的多孔陶瓷:肉眼可见的大孔整齐排列,大孔内壁还含有显微孔。从本质上讲,孔结构是受起始浆料浓度及烧成温度的影响的。本文还讨论了在这些因素影响下孔的形成机理。 | Takayuki Fukasawa Motohide Ando Tatsuki Ohji Shuzo Kanzaki 张玉珍 | 2001 | 江苏陶瓷2001，34，3： | 2 |
| 6 | Antitumor effect of monoclonal antibody-carboplatin conjugates in nude mice bearing ovarian cancer cells显示文摘 | Ota Y Fukasawa I | 1999 | Int J Clin Oncol1999，4，2： | 2 |
| 7 | Effects of postharvest ethanol vapor treatment on activities and gene expression of chlorophyll catabolic enzymes in broccoli florets显示文摘 | Asumi Fukasawa Yasuo Suzuki Hirofumi Terai Naoki Yamauchi | 2009 | Postharvest Biology and Technology2009，，2： | 2 |
| 8 | Evaluation of Pharyngeal Function between No Bolus and Bolus Propofol Induced Sedation for Advanced Upper Endoscopy显示文摘 | Shinsuke Kiriyama Hiroshi Naitoh Minoru Fukuchi Takaharu Fukasawa Kana Saito Yuichi Tabe Hayato Yamauchi Tomonori Yoshida Hiroyuki Kuwano Spiros D. Ladas | 2014 | Diagnostic and Therapeutic Endoscopy2014，，： | 2 |
| 9 | Reversible middle cerebral artery occlusion in rats using an intraluminal thread technique 显示文摘 | Kawamura S Li Y Shirasawa M Yasui N Fukasawa H | 1994 | Surg Neurol1994，41，： | 1 |
| 10 | Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity显示文摘 | SEGAWA H FUKASAWA Y MIYAMOTO K | 1999 | J Biol Chem1999，274，19： | 1 |
| 11 | An AFP-producing gastric carcinoma with features of hepatic differentiation : a case re- port 显示文摘 | Ishikura H Fukasawa Y Ogasawara K | 1985 | Cancer1985，56，4： | 1 |
| 12 | Hepatitis B virus gene mutations in the sera of three patients with coexisting hepatitis B surface antigen and anti-surface antibody显示文摘 | YUKIMASA N OHKUSHI H FUKASAWA K | 2000 | Rinsho Byori2000，48，2： | 1 |
| 13 | A mammalian in vitro centriole duplication system evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication显示文摘 | Tarapore P Okuda M Fukasawa K | 2002 | Cell Cycle2002，1，1： | 1 |
| 14 | The hemostatic effect of deacetylated chitin membrane on peritoneal injury in rabbit model 显示文摘 | Fukasawa M Abe H Masaoka T | 1992 | Jpn J Surg1992，22，： | 1 |
| 15 | Synergism of protein kinase A,protein kinase C,and myosin light-chain kinase in the secretory cascade of the pancreatic beta cell显示文摘 | Yu W Niwa T Fukasawa T | 2000 | Diabetes2000，49，： | 1 |
| 16 | Coesite exsolution from supersilicic titanite in UHP marble from the Kokchetav Massif, northern Kazakhstan显示文摘 | Ogasawara Y Fukasawa K Maruyama S | 2002 | American Mineralogist2002，87，： | 1 |
| 17 | The diagnosis of intravenous leiomyomatosis of an early stage is difficult 显示文摘 | Inaba F Furuno M Fukasawa I | 2006 | Indian J Med Sci2006，60，10： | 1 |
| 18 | Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats 显示文摘 | Kawamura S Shirasawa M Fukasawa H | 1991 | Stroke1991，22，： | 1 |
| 19 | Epileptic seizures induced by dexmedetomidine in a neonate显示文摘 | Kubota T Fukasawa T Kitamura E | | 0，，04： | 1 |
| 20 | Neuropilin-1interacts with integrin beta1and modulates pancreatic cancer cell growth,survival and invasion显示文摘 | Fukasawa M Matsushita A Korc M | 2007 | Cancer Biol Ther2007，6，8： | 1 |
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