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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 3 | 瑞士马铃薯晚疫病监测及决策支持系统PhytoPRE + 2000在网络上的实现(英文)显示文摘1990年以来 ,瑞士在全国范围内保留了一些不经防治的马铃薯田并设立了晚疫病监测网。商品生产基地马铃薯晚疫病的首次侵染信息被用来指导防治区域性病害。近 12年期间 ,有 10年晚疫病始发于 5月份 ,其中 9年是由保护地扩散到大田的。从 2 0 0 1年起 ,农民们能够在网络上得到PhytoPRE +2 0 0 0决策支持系统的服务。系统的核心是国家范围晚疫病发生的实际状态、过去及未来的天气预报资料。用晚疫病菌侵染和产孢所需的关键性气象条件 (MISP)来衡量未来天气状况的满足程度。自 1996年至 2 0 0 0年 ,MISP模型被用来指导田间晚疫病的防治。与PhytoPRE +95相比 ,在多雨年份防治次数未能减少 ,但是在干旱年份能节省 40 %以上的药剂使用。在田间试验当中 ,MISP模型在指导首次用药方面与PhytoPRE +95不相上下 ,在连续用药方面优于其它决策支持系统。在 1999年和 2 0 0 0年 ,MISP模型被整合到PhytoPRE +2 0 0 0决策支持系统。为了使信息快速传递 ,采用了网络技术。PhytoPRE+2 0 0 0是一个针对特定区域和特定地块并集建议、信息和预警为一体的决策支持系统。每日的实际病害发生图以及通过MISP预测的晚疫病发生预警图能够通过网络显示给瑞士所有马铃薯种植户。 | FORRER H R STEENBLOCK T FRIED P M | 2001 | 河北农业大学学报2001，24，2： | 2 |
| 4 | Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘 | Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A | 2010 | Journal of Food Protection2010，，2： | 2 |
| 5 | Coordinating Production and Delivery under a (z ,Z)-Type Vendor-Man-aged Inventory Contract 显示文摘 | Fry M J Kapuscinski R Olsen T L | 2001 | Manufacturing & Service Operations Management2001，3，2： | 1 |
| 6 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 7 | Using floating catchment analysis (FCA) techniques to examine intra -urban variations in accessibility to public trans- port opportunities: the example of Cardiff, Wales 显示文摘 | Langford M Higgs G Fry R | 2012 | Journal of Transport Geography2012，25，： | 1 |
| 8 | Pharmacologic treatment of consti-pation:what is new显示文摘 | Pohl D Tutuian R Fried M | | 0，，06： | 1 |
| 9 | Two α ( 1,2 ) fucosyhransferase genes on porcine chromosome 6q11 reclosely linked to the blood group inhibitor(S) and Escherichia cob F18 receptor (ECF 18 R) loci 显示文摘 | MEIJERINK E FRIES R VOGELI M J | 1997 | Mamm Genome1997，8，： | 1 |
| 10 | Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly:a double-blinded randomized controlled trial显示文摘 | Rrtgen D Kloos J Fries M | 2010 | Br J Anaesth2010，104，2： | 1 |
| 11 | Measuring ^15N-NH4^+ in marine,estuarineand fresh waters:An adaption of the ammonia diffusionmethod for samples with low ammonium concentrations显示文摘 | Holmes R M McClelland J W Sigman D M Fry B Peterson B J | 1998 | Marine Chemistry1998，60，： | 1 |
| 12 | Duodenal Bacterial overgrowth during treatment in outpatients with Omeprazote 显示文摘 | FRIED M SIEGRIST H FREI R | 1994 | GUT1994，35，1： | 1 |
| 13 | Plant growth and arbuscular mycorrhizal fungal colonization affected by exogenously applied phenolic compounds 显示文摘 | FRIES L L M PACOVSKY R S SAFIR G R | 1997 | Journal of Chemical Ecology1997，23，7： | 1 |
| 14 | Development of a symp- tom assessment instrument for chronic hemodialysis patients:the dialy- sis symptom index显示文摘 | Weisbord S D Fried L F Arnold R M | 2004 | J Pain Symptom Manage2004，27，3： | 1 |
| 15 | Sinks for 15N - enriched addi-tions to an oak forest and a red pine plantation显示文摘 | Nadelhoffer K J Downs M R Fry B | 1999 | Ecological Appli-cations1999，，： | 1 |
| 16 | Sequence-specific binding protein of s ingle-stranded and unimolecular quadruples telo meric DNA from rat hepatocytes显示文摘 | Erlitzki R Fry M | 2007 | J Biol Chem2007，272，15： | 1 |
| 17 | Thulium Fiber Laser Lithotripsy Using Tapered Fibers 显示文摘 | BLACKMON R L IRBY P B FRIED N M | 2010 | Lasers in Surgery and Medicine(S0196-8092)2010，42，： | 1 |
| 18 | Investigating variations in the provision of digital services in public libraries using network-based GIS models显示文摘 | Higgs G Langford M Fry R | 2013 | Library & Information Science Research2013，35，1： | 1 |
| 19 | Crucial weather conditions for Phytophthora infestans - a reliable tool for improved control of potato late blight显示文摘 | Cao K Q Forrer H R Fried P M | 1996 | PAV Special Report1996，，1： | 1 |
| 20 | Medical device alarms显示文摘 | BOROWSKI M GORGES M FRIED R | 2011 | Biomed Tech(Berl)2011，56，2： | 1 |
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